Physical Activity in Aging: Biological Outcomes, Functional Autonomy, and Policy Implications

A 2016 study concluded that the elderly spend 2.5 times the national average on health services (De Nardi 2016). Despite consisting of only 14 percent of the United States population, the elderly accounted for 34 percent of all medical spending, and accounted for 73 percent of all deaths (De Nardi 2016). In addition, current projections estimate that with the aging of the baby boomer generation, the percentage of the population that is older than 65 will swell to approximately 20 percent of the population by 2030 (Ortman 2014). If the medical spending holds, this will coincide with massive increases in health service utilization and costs. Costs of health services are currently a contentious topic at both the state and federal levels, with a seemingly insurmountable divide existing between the two main US political parties. This research attempted to gain better understanding of the health effects that physically active lifestyles elicit in older populations. Previous research connected biological outcomes across several systems to improvements in systemic health, but our efforts attempted to apply similar analysis to generalized activity levels in the form of various reported activities standardized using metabolic equivalent task metrics. For this study, the examined age group expanded beyond individuals that are older than 65, and instead included all ages over 50. Analysis used Metabolic Equivalent Task Minutes (METS) as a representative variable of general activity, using ordinary least squares regression to analyze effects on biological systems. It was found that with the selected model, there was minimal to no impact biologically that correlated with increasing general activity levels among the 50+ community. Secondary analyses were performed that lacked sufficient statistical power, however their results may be useful in determining further course of study. In the first of the secondary analyses, we used the exercise model to assess changes in individual perception of health. In this there were very few correlations found between biological health and perceptions of health. Finally, biological health and perception of health were regressed against several variables that were indicative of medical service utilization Analysis found that for the selected cohort, there were minimal measurable biological effects relating to exercise, but that the more active respondents correlated with higher belief in control over their health, as well as reductions in health-based restrictions on ability to perform intermediate level activities of daily living

Mixing Beef Feed Rations Containing Distillers Wet Grains

The flexibility of distillers grains has made it a major substitute for corn in beef feed rations. However, producers are having issues with feeding wet distillers grains. This study addresses three major mixing conditions: ingredient addition order, mixing time, and mixer design. The addition orders considered were hay-corn-protein-DWG and hay-DWG-protein-corn. Horizontal and vertical mixers were tested at mix times of 3, 5, and 7 min mixing a beef finishing ration containing wet distillers grains. Test results were obtained using total mixed ration and Pennsylvania State University Particle Separator analyses. Results showed that the 3-min mixing time is sufficient, thus when adding distillers grains, longer mix times are not needed. The hay- corn-protein- DWG ingredient addition order is recommended for both mixers when using liquid additives in the ration in order to avoid unwanted bundle formation. Finally, the two mixer designs were both adequate in mixing a wet distillers grains ration

Pilot evaluation of a perfused robot-assisted partial nephrectomy procedural simulation platform for single port robotic retroperitoneal approaches

Objective: In this study our objective was to develop a simulation platform for use cases in Laparoendoscopic Single Site (LESS) Surgery intended for patient-specific rehearsal prior to Robot-assisted Partial nephrectomy procedures. Patients and Surgical Procedure: This represents a simulation platform requiring no patients, although the fabrication process allows for the platform to be patient-specific. Tissue phantom 3D models were developed from de-identified CT imaging fulfilling the criteria of tumors located in the posterior lower pole of the kidney. Results: Respondents completed surveys on platform novelty and effectiveness. Agreement on simulator novelty was unanimously positive (100% agree or better). Performance evaluations reached a minimum of 80% agreement for all categories, with zero respondents. Conclusions: We have developed a highly realistic simulation platform for use in single-port robot-assisted partial nephrectomy that can be produced in a patient specific manner, which we believe will be highly useful for trainees as well as experts attempting to transfer skills to the newer platform

Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease.

Defective mitochondrial distribution in neurons is proposed to cause ATP depletion and calcium-buffering deficiencies that compromise cell function. However, it is unclear whether aberrant mitochondrial motility and distribution alone are sufficient to cause neurological disease. Calcium-binding mitochondrial Rho (Miro) GTPases attach mitochondria to motor proteins for anterograde and retrograde transport in neurons. Using two new KO mouse models, we demonstrate that Miro1 is essential for development of cranial motor nuclei required for respiratory control and maintenance of upper motor neurons required for ambulation. Neuron-specific loss of Miro1 causes depletion of mitochondria from corticospinal tract axons and progressive neurological deficits mirroring human upper motor neuron disease. Although Miro1-deficient neurons exhibit defects in retrograde axonal mitochondrial transport, mitochondrial respiratory function continues. Moreover, Miro1 is not essential for calcium-mediated inhibition of mitochondrial movement or mitochondrial calcium buffering. Our findings indicate that defects in mitochondrial motility and distribution are sufficient to cause neurological disease

FY17 Report Summaries of Five Completed Center Innovation Fund (CIF) Projects for the Highlights/Abstract Section of the FY 2018 CIF Annual Report

The Center Innovation Fund Annual Report for FY18 is an annual report for Space Technology Mission Directorate (STMD) Leadership, STMD Principle Technologists, and Center Innovation Fund Management. Attached is the Highlights/Abstract section of this annual report, which is the only section to be shared outside of NASA. Contributors were asked not to include any SBU information for these report summaries

Zero Launch Mass Three Dimensional Print Head

NASA's strategic goal is to put humans on Mars in the 2030s. The NASA Human Spaceflight Architecture Team (HAT) and NASA Mars Design Reference Architecture (DRA) 5.0 has determined that in-situ resource utilization (ISRU) is an essential technology to accomplish this mission. Additive construction technology using in-situ materials from planetary surfaces will reduce launch mass, allow structures to be three dimensionally (3D) printed on demand, and will allow building designs to be transmitted digitally from Earth and printed in space. This will ultimately lead to elimination of reliance on structural materials launched from Earth (zero launch mass of construction consumables). The zero launch mass (ZLM) 3D print head project addressed this need by developing a system that 3D prints using a mixture of in-situ regolith and polymer as feedstock, determining the optimum mixture ratio and regolith particle size distribution, developing software to convert g-code into motion instructions for a FANUC robotic arm, printing test samples, performing materials testing, and printing a reduced scale habitable structure concept. This paper will focus on the ZLM 3D Print Head design, materials selection, software development, and lessons learned from operating the system in the NASA KSC Swamp Works Granular Mechanics & Regolith Operations (GMRO) Laboratory

MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses

Complex morphological traits are the product of many genes with transient or lasting developmental effects that interact in anatomical context. Mouse models are a key resource for disentangling such effects, because they offer myriad tools for manipulating the genome in a controlled environment. Unfortunately, phenotypic data are often obtained using laboratory-specific protocols, resulting in self-contained datasets that are difficult to relate to one another for larger scale analyses. To enable meta-analyses of morphological variation, particularly in the craniofacial complex and brain, we created MusMorph, a database of standardized mouse morphology data spanning numerous genotypes and developmental stages, including E10.5, E11.5, E14.5, E15.5, E18.5, and adulthood. To standardize data collection, we implemented an atlas-based phenotyping pipeline that combines techniques from image registration, deep learning, and morphometrics. Alongside stage-specific atlases, we provide aligned micro-computed tomography images, dense anatomical landmarks, and segmentations (if available) for each specimen (N = 10,056). Our workflow is open-source to encourage transparency and reproducible data collection. The MusMorph data and scripts are available on FaceBase (www.facebase.org, https://doi.org/10.25550/3-HXMC) and GitHub (https://github.com/jaydevine/MusMorph)

Measurement of Angular Distributions and R= sigma_L/sigma_T in Diffractive Electroproduction of rho^0 Mesons

Production and decay angular distributions were extracted from measurements of exclusive electroproduction of the rho^0(770) meson over a range in the virtual photon negative four-momentum squared 0.5< Q^2 <4 GeV^2 and the photon-nucleon invariant mass range 3.8< W <6.5 GeV. The experiment was performed with the HERMES spectrometer, using a longitudinally polarized positron beam and a ^3He gas target internal to the HERA e^{+-} storage ring. The event sample combines rho^0 mesons produced incoherently off individual nucleons and coherently off the nucleus as a whole. The distributions in one production angle and two angles describing the rho^0 -> pi+ pi- decay yielded measurements of eight elements of the spin-density matrix, including one that had not been measured before. The results are consistent with the dominance of helicity-conserving amplitudes and natural parity exchange. The improved precision achieved at 47 GeV, reveals evidence for an energy dependence in the ratio R of the longitudinal to transverse cross sections at constant Q^2.Comment: 15 pages, 15 embedded figures, LaTeX for SVJour(epj) document class Revision: Fig. 15 corrected, recent data added to Figs. 10,12,14,15; minor changes to tex