2,187 research outputs found

    aFold – using polynomial uncertainty modelling for differential gene expression estimation from RNA sequencing data

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    Data normalization and identification of significant differential expression represent crucial steps in RNA-Seq analysis. Many available tools rely on assumptions that are often not met by real data, including the common assumption of symmetrical distribution of up- and down-regulated genes, the presence of only few differentially expressed genes and/or few outliers. Moreover, the cut-off for selecting significantly differentially expressed genes for further downstream analysis often depend on arbitrary choices

    Non-rigid hole band in the extended t-J model

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    The dispersion of one hole in an extended tt-JJ model with additional hopping terms to second and third nearest neighbours and a frustration term in the exchange part has been investigated. Two methods, a Green's function projection technique describing a magnetic polaron of minimal size and the exact diagonalization of a 4∗44*4 lattice, have been applied, showing reasonable agreement among each other. Using additional hopping integrals which are characteristic for the CuO2_2 plane in cuprates we find in the nonfrustrated case an isotropic minimum of the dispersion at the point (π/2,π/2)(\pi/2,\pi/2) in kk-space in good coincidence with recent angle-resolved photoemission results for the insulating compound Sr2_2CuO2_2Cl2_2. Including frustration or finite temperature which shall simulate the effect of doping, the dispersion is drastically changed such that a flat region and an extended saddle point may be observed between (π/2,0)(\pi/2,0) and (π,0)(\pi,0) in agreement with experimental results for the optimally doped cuprates.Comment: 14 pages, LaTeX, 6 figures on request, submitted to Zeitschrift fuer Physi
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