Foreign Accent Syndrome Secondary to Medication Withdrawal: A Case Report

Objective: The purpose of this case report is to demonstrate a possible alternative etiology related to dopamine may exist for foreign accent syndrome (FAS). Methods: A 79-year-old, 205 pound, Caucasian woman originally presented to the department of Neurology for treatment and subsequently to the pharmacist pharmacotherapy service for evaluation of bilateral upper extremity tremor of high amplitude but was found to also exhibit FAS. Discussion: This case report contributes to the limited literature regarding foreign accent syndrome and adds to the few case reports of psychogenic origin, as opposed to the majority, which are of neurogenic origin. This also represents the first case that seems related to withdrawal of medication rather than psychotic exacerbation and ranks a six on the Naranjo algorithm. Conclusion: FAS is a rare disorder and little is understood about it. This case presentation also suggests that chronic use of high-dose dopamine and/or anticholinergic agents may alter pathways in the brain, which in this case, may have potentially contributed to the development of FAS. There remain many unanswered questions regarding FAS, but hopefully more clarity may be found as more cases are discovered and published. Conflict of Interest I declare no conflicts of interest or financial interests that the authors or members of their immediate families have in any product or service discussed in the manuscript, including grants (pending or received), employment, gifts, stock holdings or options, honoraria, consultancies, expert testimony, patents and royalties.   Type: Case Stud

An Empirical Bayesian Approach to Quantify Multi-Scale Spatial Structural Diversity in Remote Sensing Data

Landscape structure is as much a driver as a product of environmental and biological interactions and it manifests as scale-specific, but also as multi-scale patterns. Multi-scale structure affects processes on smaller and larger scales and its detection requires information from different scales to be combined. Herein, we propose a novel method to quantify multi-scale spatial structural diversity in continuous remote sensing data. We combined information from different extents with an empirical Bayesian model and we applied a new entropy metric and a value co-occurrence approach to capture heterogeneity. We tested this method on Normalized Difference Vegetation Index data in northern Eurasia and on simulated data and we also tested the effect of coarser pixel resolution. We find that multi-scale structural diversity can reveal itself as patches and linear landscape features, which persist or become apparent across spatial scales. Multi-scale line features reveal the transition zones between spatial regimes and multi-scale patches reveal those areas within transition zones where values are most different from each other. Additionally, spatial regimes themselves can be distinguished. We also find the choice of scale need not be informed by typical length-scales, which makes the method easy to implement. The proposed multi-scale approach can be applied to other contexts, following the roadmap we pave out in this study and using the tools available in the accompanying R package StrucDiv

Fast Mapping of Terahertz Bursting Thresholds and Characteristics at Synchrotron Light Sources

Dedicated optics with extremely short electron bunches enable synchrotron light sources to generate intense coherent THz radiation. The high degree of spatial compression in this so-called low-alpha optics entails a complex longitudinal dynamics of the electron bunches, which can be probed studying the fluctuations in the emitted terahertz radiation caused by the micro-bunching instability ("bursting"). This article presents a "quasi-instantaneous" method for measuring the bursting characteristics by simultaneously collecting and evaluating the information from all bunches in a multi-bunch fill, reducing the measurement time from hours to seconds. This speed-up allows systematic studies of the bursting characteristics for various accelerator settings within a single fill of the machine, enabling a comprehensive comparison of the measured bursting thresholds with theoretical predictions by the bunched-beam theory. This paper introduces the method and presents first results obtained at the ANKA synchrotron radiation facility.Comment: 7 pages, 7 figures, to be published in Physical Review Accelerators and Beam

A high-throughput technique for determining grain boundary character non-destructively in microstructures with through-thickness grains

Grain boundaries (GBs) govern many properties of polycrystalline materials. However, because of their structural variability, our knowledge of GB constitutive relations is still very limited. We present a novel method to characterise the complete crystallography of individual GBs non-destructively, with high-throughput, and using commercially available tools. This method combines electron diffraction, optical reflectance and numerical image analysis to determine all five crystallographic parameters of numerous GBs in samples with through-thickness grains. We demonstrate the technique by measuring the crystallographic character of about 1,000 individual GBs in aluminum in a single run. Our method enables cost- and time-effective assembly of crystallography–property databases for thousands of individual GBs. Such databases are essential for identifying GB constitutive relations and for predicting GB-related behaviours of polycrystalline solids.United States. Department of Energy. Office of Basic Energy Sciences (award no DE-SC0008926)MIT International Science and Technology InitiativesNational Science Foundation (U.S.) (grant DMR-1003901

Simultaneous Detection of Longitudinal and Transverse Bunch Signals at a Storage Ring

To understand and control the dynamics in the longitudinal phase space, time-resolved measurements of different bunch parameters are required. For a reconstruction of this phase space, the detector systems have to be synchronized. This reconstruction can be used e.g. for studies of the micro-bunching instability. It occurs if the interaction of the bunch with its own radiation leads to the formation of sub-structures on the longitudinal bunch profile. These sub-structures can grow rapidly -- leading to a sawtooth-like behaviour of the bunch. At KARA, we use a fast-gated intensified camera for energy spread studies, Schottky diodes for coherent synchrotron radiation studies as well as electro-optical spectral decoding for longitudinal bunch profile measurements. For a synchronization, a hardware synchronization scheme is used which compensates for eventual hardware delays. In this paper, the different experimental setups and their synchronization are discussed and first results of synchronous measurements are presented

NASA Environmentally Responsible Aviation Hybrid Wing Body Flow-Through Nacelle Wind Tunnel CFD

Wind tunnel tests of a 5.75% scale model of the Boeing Hybrid Wing Body (HWB) configuration were conducted in the NASA Langley Research Center (LaRC) 14'x22' and NASA Ames Research Center (ARC) 40'x80' low speed wind tunnels as part of the NASA Environmentally Responsible Aviation (ERA) Project. Computational fluid dynamics (CFD) simulations of the flow-through nacelle (FTN) configuration of this model were performed before and after the testing. This paper presents a summary of the experimental and CFD results for the model in the cruise and landing configurations

Electro-Optical Diagnostics at KARA and FLUTE – Results and Prospects

Electro-optical (EO) methods are nowadays well-proven diagnostic tools, which are utilized to detect THz fields in countless experiments. The world’s first near-field EO sampling monitor at an electron storage ring was developed and installed at the KIT storage ring KARA (Karlsruhe Research Accelerator) and optimized to detect longitudinal bunch profiles. This experiment with other diagnostic techniques builds a distributed, synchronized sensor network to gain comprehensive data about the phase-space of electron bunches as well as the produced coherent synchrotron radiation (CSR). These measurements facilitate studies of physical conditions to provide, at the end, intense and stable CSR in the THz range. At KIT, we also operate FLUTE (Ferninfrarot Linac- und Test-Experiment), a new compact versatile linear accelerator as a test facility for novel techniques and diagnostics. There, EO diagnostics will be implemented to open up possibilities to evaluate and compare new techniques for longitudinal bunch diagnostics. In this contribution, we will give an overview of results achieved, the current status of the EO diagnostic setups at KARA and FLUTE and discuss future prospects

Longitudinal Beam Dynamics and Coherent Synchrotron Radiation at cSTART

The compact STorage ring for Accelerator Research and Technology (cSTART) project aims to store electron bunches of LWFA-like beams in a very large momentum acceptance storage ring. The project will be realized at the Karlsruhe Institute of Technology (KIT, Germany). Initially, the Ferninfrarot Linac- Und Test-Experiment (FLUTE), a source of ultra-short bunches, will serve as an injector for cSTART to benchmark and emulate laser-wakefield accelerator-like beams. In a second stage a laser-plasma accelerator will be used as an injector, which is being developed as part of the ATHENA project in collaboration with DESY and Helmholtz Institute Jena (HIJ). With an energy of 50 MeV and damping times of several seconds, the electron beam does not reach equilibrium emittance. Furthermore, the critical frequency of synchrotron radiation is 50 THz and in the same order as the bunch spectrum, which implies that the entire bunch radiates coherently. We perform longitudinal particle tracking simulations to investigate the evolution of the bunch length and spectrum as well as the emitted coherent synchrotron radiation. Finally, different options for the RF system are discussed