Information Security Synthesis in Online Universities

Information assurance is at the core of every initiative that an organization executes. For online universities, a common and complex initiative is maintaining user lifecycle and providing seamless access using one identity in a large virtual infrastructure. To achieve information assurance the management of user privileges affected by events in the user's identity lifecycle needs to be the determining factor for access control. While the implementation of identity and access management systems makes this initiative feasible, it is the construction and maintenance of the infrastructure that makes it complex and challenging. The objective of this paper1 is to describe the complexities, propose a practical approach to building a foundation for consistent user experience and realizing security synthesis in online universities.Comment: 20 page

Humans and the Water Environment: The Need for Coordinated Data Collection

Efforts to observe humans in relation to nature over time and at large scale are few and disjointed in ways that impede progress in building scientific foundations for sustainability. Two water-oriented national-scale case studies highlight the challenges of integrating existing natural system and social system data: one concerns the influence of environmental attitudes and water quality on water conservation efforts; the other explores relationships between environmental attitudes, water quality and recreation behavior. The case studies show that coupled research conducted at large scale can yield new insights, but uncoordinated data limit meaningful inference. We propose salient features of a coordinated observation program for water

Air temperature, thaw depth and total organic carbon pools in the active layer from thaw slump soils in the Lena Delta, Russia measured in 2019

The dataset comprises the thaw depth, the total organic carbon pools in the active layer measured at different thaw slump soils in the Lena Delta, Siberia, Russia in July 2019

Carbon dioxide and and methane flux from thaw slump soils in the Lena Delta, Russia measured in 2016 and 2019

The dataset comprises in situ CO2 and CH4 fluxes from different non-vegetated soils in an active thaw slump in the Lena Delta, Siberia, Russia, measured in July 2019 and July 2019

Active layer temperature profiles from thaw slump soils in the Lena Delta, Russia measured in 2016

The dataset comprises the active layer temperature profiles measured at different thaw slump soils in the Lena Delta, Siberia, Russia in July 2016

Carbon dioxide and and methane flux data, temperature and thaw depth from thaw slump soils in the Lena Delta, Russia measured in 2016 and 2019

The dataset comprises in situ CO2 and CH4 fluxes, active layer depths, thawed carbon pools and soil temperatures from different non-vegetated soils in an active thaw slump in the Lena Delta, Siberia, Russia, measured in July 2016 and July 2019

Active layer temperature profiles from thaw slump soils in the Lena Delta, Russia measured in 2019

The dataset comprises the active layer temperature profiles measured at different thaw slump soils in the Lena Delta, Siberia, Russia in July 2019

Case Report: Arterial Wall Inflammation in Atherosclerotic Cardiovascular Disease is Reduced by Olamkicept (sgp130Fc)

Inflammation is a strong driver of atherosclerotic cardiovascular disease (ASCVD). There is a large unmet need for therapies that prevent or reduce excessive inflammation while avoiding systemic immunosuppression. We showed previously that selective inhibition of pro-inflammatory interleukin-6 (IL-6) trans-signalling by the fusion protein olamkicept (sgp130Fc) prevented and reduced experimental murine atherosclerosis in low-density lipoprotein receptor-deficient (Ldlr -/-) mice on a high-fat, high-cholesterol diet independently of low-density lipoprotein (LDL) cholesterol metabolism. Therefore, we allowed compassionate use of olamkicept (600 mg intravenously biweekly for 10 weeks) in a patient with very-high-risk ASCVD. Despite optimal LDL cholesterol under maximum tolerated lipid-lowering treatment, the patient had a remaining very high risk for future cardiovascular events related to significant arterial wall inflammation with lipoprotein (a) [Lp(a)]-cholesterol as the main contributor. 18Fluorodeoxyglucose positron emission tomography/computed tomography (18FDG PET/CT) measurements were performed before and after the treatment period. Olamkicept reduced arterial wall inflammation in this patient without interfering with lipoprotein metabolism. No clinical or laboratory side effects were observed during or after treatment with olamkicept. Our findings in this patient matched the results from our mechanistic study in Ldlr -/- mice, which were extended by additional analyses on vascular inflammation. Olamkicept may be a promising option for treating ASCVD independently of LDL cholesterol metabolism. A Phase II trial of olamkicept in ASCVD is currently being prepared