INFLUENCE OF DIFFERENT SURFACE MATERIALS ON THE FOULING PROCESS IN A MICROSTRUCTURED HEAT EXCHANGER UNDER LAMINAR REGIME

Microstructure devices are well known for their excellent performance with regard to heat and mass transfer. Microstructured heat exchangers show significant advantages in comparison with conventional heat exchangers. The unique properties of a microreaction system show high overall heat transfer coefficients for example. Small characteristic dimensions are in the order of a few hundred μm (Schubert et al., 1998, 2001; Worz et al, 1998). Due to the small dimensions, an increased pressure drop is combined with excellent heat transfer properties. But the small channels are prone to fouling processes. The accumulation of crystalline deposits is a severe problem. An additional wall layer causes a decrease of the overall heat transfer coefficient. Therefore the attention has been directed to the reduction of possible fouling processes within the channels. The fouling can be subdivided in two parts: First into the induction period and second into the so-called fouling period itself (Lund et al., 1981; Forster et al., 1999a, 1999b, and 2000). For the investigations a special electrically heated micro heat exchanger with changeable foils of different surface materials (stainless steel, FEP, DLC) was developed. The foil temperature is electronically controlled to a constant level of 100°C. A solution of calciumnitrate/sodiumhydrogencarbonate is pumped under laminar flow conditions through the channels of the microstructured part. The high temperature causes the precipitation of solid calciumcarbonate on the surface. The results for all materials, the uncoated stainless steel and the DLC and FEP coated heat transfer surfaces, show typical fouling behaviour with an induction period, followed by an asymptotic built-up of the deposited calcium carbonate. The fouling plot of DLC and FEP coated heat transfer surfaces contradict the hypothesis that the use of such materials leads to much longer induction periods. There is no influence of the surface material found on the induction period and the gradient of the fouling period in the laminar flow regime

METALLIC MICRO HEAT EXCHANGERS: PROPERTIES, APPLICATIONS AND LONG TERM STABILITY

Micro heat exchangers, which until recently have been implemented only at laboratory scale, are now being available for industrial applications. They are well known for their superior heat transfer properties due to the large surface-to-volume ratio. But there are little data available on the long term stability of these devices. In this paper application several application examples for micro heat exchangers made of stainless steel are presented. The devices consist of stainless steel foils providing numerous micro channels generated by mechanical micromachining or wet chemical etching. A number of the foils are arranged in a specific way and bonded together. Device property descriptions as well as some possible application examples show the potential of metallic microstructure devices. Results on two crossflow microstructure heat exchangers running in long term tests are presented. Both devices have been tested for more than 8000 hours each, using deionised water as test fluid. Experimental data on the heat transfer properties and the pressure drop are given and compared. It was found that the heat transfer capabilities were significantly decreased within the first few hundred hours of testing and then run into a saturation state. Performance degradation may be due to a fouling layer deposited on the heat exchange surface. Some other experimental applications in which fouling was expected to cause problems are described briefly

Extending political participation in China: new opportunities for citizens in the policy process

Authoritarian political systems are portrayed as offering few opportunities for citizens to participate in politics – particularly in the policy process. This paper’s contribution is to set out new mechanisms that enable Authoritarian political systems are portrayed as offering few opportunities for citizens to participate in politics – particularly in the policy process. This paper’s contribution is to set out new mechanisms that enable Chinese citizens to evaluate government performance, contribute to decision-making, shape policy agendas and feed back on implementation. Based on fieldwork in the city of Hangzhou, we argue that the local party-state orchestrates citizen participation in the policy process, but members of the public nevertheless do have influence. Political participation is widening in China, but it is still controlled. It is not yet clearly part of a process of democratization, but it does establish the principle of citizen rights to oversee the government

Integrated results and policy implications

Contains fulltext : 132016.pdf (publisher's version ) (Open Access)iv, 33 p

Towards open business models: Some challenges and how to overcome them

Contains fulltext : 132018.pdf (publisher's version ) (Open Access)iv, 55 p

Influence of Growth Method on K3Sb Photocathode Structure and Performance

Future high brightness photoelectron sources delivering gt;100 mA average current call for a new generation of photocathodes. Materials which qualify for this purpose should exhibit low intrinsic emittance, long lifetime and high quantum efficiency at photon energies in the visible range of the spectrum to relax drive laser requirements. A combination of material science techniques are used to determine the influence of the growth parameters on structure and performance of photocathode materials . In situ XRR, XRD and GiSAXS measurements were performed at the synchrotron radiation sources, NSLS and CHESS. The growth of K3Sb, a precursor material of one of the prime candidates CsK2Sb, was studied intensively to optimize this intermediate growth step in terms of quantum efficiency and roughness. Three methods, a layer by layer type and a super lattice type were examined. K3Sb exists in two crystallographic phases, namely cubic and hexagonal. The cubic phase exhibits a higher quantum efficiency at 532 nm than the hexagonal phase and transforms more easily into CsK2Sb, tuning this phase is believed to be one of the key parameters in the CsK2Sb growt

A blood-free modeling approach for the quantification of the blood-to-brain tracer exchange in TSPO PET imaging

Introduction: Recent evidence suggests the blood-to-brain influx rate (K1) in TSPO PET imaging as a promising biomarker of blood–brain barrier (BBB) permeability alterations commonly associated with peripheral inflammation and heightened immune activity in the brain. However, standard compartmental modeling quantification is limited by the requirement of invasive and laborious procedures for extracting an arterial blood input function. In this study, we validate a simplified blood-free methodologic framework for K1 estimation by fitting the early phase tracer dynamics using a single irreversible compartment model and an image-derived input function (1T1K-IDIF). Methods: The method is tested on a multi-site dataset containing 177 PET studies from two TSPO tracers ([11C]PBR28 and [18F]DPA714). Firstly, 1T1K-IDIF K1 estimates were compared in terms of both bias and correlation with standard kinetic methodology. Then, the method was tested on an independent sample of [11C]PBR28 scans before and after inflammatory interferon-α challenge, and on test–retest dataset of [18F]DPA714 scans. Results: Comparison with standard kinetic methodology showed good-to-excellent intra-subject correlation for regional 1T1K-IDIF-K1 (ρintra = 0.93 ± 0.08), although the bias was variable depending on IDIF ability to approximate blood input functions (0.03–0.39 mL/cm3/min). 1T1K-IDIF-K1 unveiled a significant reduction of BBB permeability after inflammatory interferon-α challenge, replicating results from standard quantification. High intra-subject correlation (ρ = 0.97 ± 0.01) was reported between K1 estimates of test and retest scans. Discussion: This evidence supports 1T1K-IDIF as blood-free alternative to assess TSPO tracers’ unidirectional blood brain clearance. K1 investigation could complement more traditional measures in TSPO studies, and even allow further mechanistic insight in the interpretation of TSPO signal

Thin-Film Metamaterials called Sculptured Thin Films

Morphology and performance are conjointed attributes of metamaterials, of which sculptured thin films (STFs) are examples. STFs are assemblies of nanowires that can be fabricated from many different materials, typically via physical vapor deposition onto rotating substrates. The curvilinear--nanowire morphology of STFs is determined by the substrate motions during fabrication. The optical properties, especially, can be tailored by varying the morphology of STFs. In many cases prototype devices have been fabricated for various optical, thermal, chemical, and biological applications.Comment: to be published in Proc. ICTP School on Metamaterials (Augsut 2009, Sibiu, Romania

Target actionability review to evaluate CDK4/6 as a therapeutic target in paediatric solid and brain tumours

BACKGROUND: Childhood cancer is still a leading cause of death around the world. To improve outcomes, there is an urgent need for tailored treatment. The systematic evaluation of existing preclinical data can provide an overview of what is known and identify gaps in the current knowledge. Here, we applied the target actionability review (TAR) methodology to assess the strength and weaknesses of available scientific literature on CDK4/6 as a therapeutic target in paediatric solid and brain tumours by structured critical appraisal. METHODS: Using relevant search terms in PubMed, a list of original publications investigating CDK4/6 in paediatric solid tumour types was identified based on relevancy criteria. Each publication was annotated for the tumour type and categorised into separate proof-of-concept (PoC) data modules. Based on rubrics, quality and experimental outcomes were scored independently by two reviewers. A third reviewer evaluated and adjudicated score discrepancies. Scores for each PoC module were averaged for each tumour type and visualised in a heatmap matrix in the publicly available R2 data portal. RESULTS AND CONCLUSIONS: This CDK4/6 TAR, generated by analysis of 151 data entries from 71 publications, showed frequent genomic aberrations of CDK4/6 in rhabdomyosarcoma, osteosarcoma, high-grade glioma, medulloblastoma, and neuroblastoma. However, a clear correlation between CDK4/6 aberrations and compound efficacy is not coming forth from the literature. Our analysis indicates that several paediatric indications would need (further) preclinical evaluation to allow for better recommendations, especially regarding the dependence of tumours on CDK4/6, predictive biomarkers, resistance mechanisms, and combination strategies. Nevertheless, our TAR heatmap provides support for the relevance of CDK4/6 inhibition in Ewing sarcoma, medulloblastoma, malignant peripheral nerve sheath tumour and to a lesser extent neuroblastoma, rhabdomyosarcoma, rhabdoid tumour and high-grade glioma. The interactive heatmap is accessible through R2 [r2platform.com/TAR/CDK4_6]