Endovascular Treatment of Anterior Circulation Cerebral Aneurysms by Using Guglielmi Detachable Coils: A 10-Year Single-Center Experience with Special Emphasis on the Use of Three-Dimensional GDC

Purpose:: To analyze the immediate, long-term angiographic and clinical results of endovascular treatment of anterior circulation aneurysms with special regard to the use of three-dimensional Guglielmi detachable coils (3D-GDC). Patients and Methods:: Between 1993 and 2003, 116 patients with 116 anterior circulation aneurysms were treated. 88 patients (75.9%) underwent embolization due to high surgical risk. To analyze the use of 3D-GDC, patients treated before (group 1) and after (group 2) implementation of 3D-GDC in 1999 were compared. Mean duration of angiographic follow-up was 13.9 months. Clinical follow-up was set at hospital discharge and using a questionnaire for long-term follow-up (mean 46.8 months). Results:: Overall, at initial intervention, complete occlusion was achieved in 65 aneurysms (56.0%), neck remnant in 42 (36.2%), and incomplete occlusion in nine (7.8%). Procedure-related permanent morbidity was 4.3% and mortality 2.6%. Recanalization rate at radiologic follow-up was 16.7%. Occlusion success at initial treatment correlated with aneurysm neck size (p = 0.001). Clinical outcome at hospital discharge was dependent on Hunt & Hess grade at presentation (p = 0.01). Subgroup analysis revealed that the use of 3D-GDC produced a higher initial obliteration rate compared to standard coils, but did not reach statistical significance (p = 0.059). Neither aneurysm neck size nor aneurysm dome size nor the use of 3D-GDC significantly influenced recanalization rate. Conclusion:: GDC technology is effective and safe, particularly in case of patients with high surgical risk. Aneurysm neck size was predictive of occlusion rate and Hunt & Hess grade of clinical outcome. Introduction of 3D-GDC probably improved occlusion rate, but did not significantly influence recanalization rat

Multifunctional shade‐tree management in tropical agroforestry landscapes – a review

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87099/1/j.1365-2664.2010.01939.x.pd

Wissenschaftliches Reisen

Die Themenklasse 2020/21 möchte mit ihrer Studie einen Grundstein in Richtung nachhaltiger Reisen an der HU legen. Sie hat in ihrer Forschungsarbeit eine wichtige Quelle der CO2-Emissionen, wissenschaftliche (Dienst)-Reisen an der Humboldt-Universität zu Berlin (HU), analysiert. Drei Arbeitsgruppen gingen mit quantitativen sowie qualitativen Methoden zwei Semester lang mehreren Fragestellungen nach: Wie groß ist der CO2-Fußabdruck von wissenschaftlichen (Dienst)-Reisen? Aus welchen Gründen und in welchem Umfang werden Dienstreisen angetreten? Gibt es Einsparungspotenziale bzw. wie kann eine eventuelle Kompensation der CO2-Emissionen gestaltet werden? Mit der Beantwortung dieser Fragen stellt die Forschungsarbeit die Datengrundlage der Auswirkungen von wissenschaftlichem Reisen an der HU bereit und bildet Erklärungsmuster für wissenschaftliche Reisen ab. Ebenso zeigt sie Handlungsoptionen zur Speicherung bzw. Einsparung von CO2-Emissionen durch Dienstreisen an der HU auf. Das Zusammenspiel dieser drei Teilbereiche soll als Basis für einen Wandel hin zu klimabewussterem Reisen und der Implementierung eines CO2-Kompensationssystems an der HU fungieren. Die Themenklasse positioniert sich damit auch nachdrücklich zu den Möglichkeiten und der Verantwortung des Wissenschaftsbetriebes für mehr Nachhaltigkeit

Community-developed checklists for publishing images and image analysis

Images document scientific discoveries and are prevalent in modern biomedical research. Microscopy imaging in particular is currently undergoing rapid technological advancements. However for scientists wishing to publish the obtained images and image analyses results, there are to date no unified guidelines. Consequently, microscopy images and image data in publications may be unclear or difficult to interpret. Here we present community-developed checklists for preparing light microscopy images and image analysis for publications. These checklists offer authors, readers, and publishers key recommendations for image formatting and annotation, color selection, data availability, and for reporting image analysis workflows. The goal of our guidelines is to increase the clarity and reproducibility of image figures and thereby heighten the quality of microscopy data is in publications.Comment: 28 pages, 8 Figures, 3 Supplmentary Figures, Manuscript, Essential recommendations for publication of microscopy image dat