Efficient simulation of complex capillary effects in advanced manufacturing processes using the finite volume method

The accurate representation of surface tension driven flows in multiphase systems is considered a challeng- ing problem to resolve numerically. Although there have been extensive works in the past that have presented approaches to resolve these so called Marangoni flows at the phase boundaries, the question of how to efficiently resolve the interface in a universal and conservative manner remains largely open in comparison. Such problems are of high practical relevance in many manufacturing processes, especially in the microfluidic regime where capillary effects dominate the local force equilibria. In this work, we present a freely available numerical solver based on the Finite Volume Method that is able to resolve arbitrarily complex, incompressible multiphase systems with the mentioned physics at phase boundaries. An efficient solution with respect to the number of degrees of freedom can be obtained by either using high order WENO stencils or by employing adaptive cell refinement. We demonstrate the capabilities of the solver by investigating a model benchmark case as well as a single track laser melting process that is highly relevant within laser additive manufacturing

High-speed Schottky photodiode on semi-insulating GaAs

A high-speed GaAs photodiode has been fabricated on a GaAs semi-insulating substrate. The photodiode has an active area of 8 μm × 15 μm and a bandwidth in excess of 9 GHz. This Schottky photodiodes is suitable for monolithic integration with other optoelectronic components

Influence of the Constitutive Model for Shotcrete on the Predicted Structural Behavior of the Shotcrete Shell of a Deep Tunnel

The aim of the present paper is to investigate the influence of the constitutive model for shotcrete on the predicted displacements and stresses in shotcrete shells of deep tunnels. Previously proposed shotcrete models as well as a new extended damage plasticity model for shotcrete are evaluated in the context of 2D finite element simulations of the excavation of a stretch of a deep tunnel by means of the New Austrian Tunneling Method. Thereby, the behavior of the surrounding rock mass is described by the commonly used HoekBrown model. Differences in predicted evolutions of displacements and stresses in the shotcrete shell, resulting from the different shotcrete models, are discussed and simulation results are compared to available in situ measurement data.(VLID)3044916Version of recor

Vertical FET's in GaAs

Vertical FET's in GaAlAs material systems have been fabricated. The present structure makes possible extremely short (less than 1000-Å) channel devices which are beyond the reach of optical lithographic processes. Devices with transconductance g_m high as 280 mS/mm have been obtained

Simultaneous and synchronous bilateral endoscopic treatment of urolithiasis : a multicentric study

The general prevalence of bilateral urolithiasis has risen to 15% and bilateral non-simultaneous treatment has been reported to have good outcomes. The objective of this study was to evaluate the effectiveness and safety of simultaneous bilateral endoscopic surgery (SBES). An international multicenter analysis was performed between May 2015 and December 2017. All patients with bilateral stone disease that underwent SBES were included. Patients were treated under general anesthesia in either the supine or lithotomy position. Demographic, clinical, intraoperative and postoperative data were analyzed. A total of 47 patients were included. Mean age was 53.8 years and 70% of the patients were males. The mean American Society of Anesthesiology (ASA) score was 2. The mean diameter of right- and left-sided stones was 29.43 mm (2-83 mm) and 31.15 (4-102 mm), respectively. Staghorn stones were treated in 18 cases (8 right-sided and 10 left-sided), four of them were defined as complete staghorn. The procedures performed were 42 cases of bilateral URS and PCNL and ureteroscopy. Additionally, 5 bilateral flexible ureteroscopy (fURS) cases were described. Intraoperative complications occurred in five patients: four of them were classified as Clavien-Dindo (CD) I and one as CD II. Postoperatively, there were two cases with CD I, 6 with CD II and one CD IIIa. The stone-free status was 70%. Residual stones (30%) were detected only on the side treated for high-volume (complete) staghorn calculi. SBES is a feasible, effective and safe procedure. It may potentially avoid repeated anesthetic sessions as needed for staged procedures and reduce the length of patients' hospital stay

Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort

BACKGROUND: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. METHODS: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. RESULTS: SVR24 rates were 46.1% (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1, 2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced 651 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with 651 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not 655. CONCLUSIONS: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginterferon alfa-2a/ribavirin