Success Factors for Recommender Systems From a Customers’ Perspective

Recommender systems have become an integral part of today’s ecommerce landscape and are no longer only deployed on websites but also increasingly serve as a basis for the delivery of personalized product recommendations in various communication channels. Within this paper, we present a brief overview of popular and commonly used recommender algorithms as well as current cutting-edge algorithmic advances. We examine consumers’ preferences regarding product recommendations in advertisements across different media channels within the apparel industry by applying choice-based conjoint analysis. The findings of studies for young male (n = 170) and female (n = 162) consumers show that the recommender algorithm is not necessarily of upmost importance. In contrast, the advertising channel is of highest relevance with banner advertising being the least preferred channel. Moreover, differences between male and female respondents are outlined. Finally, implications for retailers and advertisers are discussed and a brief outlook on future developments is presented

Glow Discharge Optical Emission Spectrometry (GDOES), an Effectiveness Method for Characterizing Composition of Surfaces and Coatings

Within the frame of this work, the technical procedures and real advantages of using Glow Discharge Optical Emission Spectroscopy (GDOES) for establishing depth concentration profiles of surfaces are presented. GDOES can detect low concentrations with high accuracy. It can be used for either quantitative bulk analysis (QBA) or quantitative depth profiling (QDP) in the nanometer to micron range. Non-conductive and conductive samples can be analysed. The main applications of this spectral method are related to different technology fields such as: heat treatment processes, casting, heat and cold forming processes, thermochemical treatments, electro-chemical processes (galvanic coatings), chemical and physical vapour depositions (CVD, PVD), thermal oxidation processes and anodizing, thin-films and others

COSMIC-2 Precise Orbit Determination

We present initial results for post-processed GNSS orbit and clock estimation for the FORMOSAT-7/COSMIC-2 (Constellation Observing System for Meteorology, Ionosphere, and Climate) constellation. The six COSMIC-2 satellites launched on June 25, 2019 into a 24 deg inclination, ~725 km circular orbit. The primary Tri-GNSS Radio-occultation Receiver System (TGRS) payload tracks GPS and GLONASS signals on two upward looking precise orbit determination (POD) antennas. We evaluate three GPS and GPS+GLONASS POD solutions applied at the COSMIC Data Analysis and Archive Center using the Bernese GNSS Software. The obtained results are very consistent for the six satellites. Orbit precision estimates are below the 10 cm and 0.1 mm/s 3D position and velocity requirements, respectively. A test case applying carrier phase ambiguity resolution indicates this technique may support the generation of more precise orbits in the future

Synthesis, structural characterization, and thermodynamic properties of 11Å Al‐tobermorite

In the present paper, the structure as well as the solubility and thermodynamic data of synthesized Al‐tobermorite is discussed. 29Si NMR and XRD prove the successful synthesis of an Al‐tobermorite with a ratio of Al/(Al + Si) = 0.1. The aluminum is incorporated in the branching (Q3) sites of the silicate chains. Solubility of the synthesized Al‐tobermorite can be calculated from the measured ionic concentrations from storage in aqueous solution, which show little variation over time. The tobermorite remains stable in aqueous solution. Consequently, an equilibrium between aqueous solution and the synthesized Al‐tobermorite can be assumed. On the basis of the experiments, thermodynamic data for Al‐tobermorite can be estimated and presented in the present paper.AbstraktIn der vorliegenden Publikation werden die Löslichkeit undweitere thermodynamische Daten von synthetischem Al‐Tobermorit diskutiert. 29SINMR und XRD wurden verwendet um die erfolgreiche Synthese des Al‐Tobermorit miteinem Verhältnis von Al/(Al + Si) = 0,1 nachzuweisen. Der Einbau des Aluminiumsfindet in den “Branching sites” (Q3) der Silikatketten statt. Die Löslichkeitwurde anhand der Ionenkonzentrationen aus der Lagerung des Al‐Tobermorit inWasser bei verschiedenen Temperaturen bestimmt. Anhand der Ergebnisse kanngezeigt werden, dass der Einbau von Al die Löslichkeit der Tobermoriterniedrigt. Neue thermodynamische Daten werden präsentiert.</p

Acute Motor Axonal Neuropathy in a Patient with Metastatic Pancreatic Neuroendocrine Tumor Receiving Chemotherapy with Capecitabine and Temozolomide: A Case Report

We report a case of a 37- year old female patient with metastatic pancreatic neuroendocrine tumor that developed acute motor axonal neuropathy after receiving chemotherapy with capecitabine and temozolomide. She had repeatedly progressed after several surgical resections of her liver metastases, other hepatic directed procedures, several sessions of peptide receptor radionuclide therapy and two systemic treatment lines. When we started a third line therapy with capecitabine (1500 mg absolute twice daily, day 1-14) and temozolomide (360 mg absolute in two divided doses on day 1-5) in a 28 days long cycle, she unexpectedly developed a progressive weakness of the upper and lower limbs and dysphagia. The diagnosis of acute motor axonal neuropathy was confirmed by nerve conduction studies. The patient`s condition improved rapidly after chemotherapy was stopped and plasma exchange (nine sessions) as well as a maintenance therapy with intravenous immunoglobulins was started. She was almost asymptomatic seven months after onset of symptoms. This case describes a previously unreported association between acute motor axonal neuropathy and chemotherapy with capecitabine and temozolomide

An application of physical flexibility and software reconfigurability for the automation of battery module assembly

Batteries are a strategic technology to decarbonize conventional automotive powertrains and enable energy policy turnaround from fossil fuels to renewable energy. The demand for battery packs is rising, but they remain unable to compete with conventional technologies, primarily due to higher costs. Major sources of cost remain in manufacturing and assembly. These costs can be attributed to a need for high product quality, material handling complexity, uncertain and fluctuating production volumes, and an unpredictable breadth of product variants. This research paper applies the paradigms of flexibility from a mechanical engineering perspective, and reconfigurability from a software perspective to form a holistic, integrated manufacturing solution to better realize product variants. This allows manufacturers to de-risk investment as there is increased confidence that a facility can meet new requirements with reduced effort, and also shows how part of the vision of Industry 4.0 associated with the integration and exploitation of data can be fulfilled. A functional decomposition of battery packs is used to develop a foundational understanding of how changes in customer requirements can result in physical product changes. A Product, Process, and Resource (PPR) methodology is employed to link physical product characteristics to physical and logical characteristics of resources. This mapping is leveraged to enable the design of a gripper with focused flexibility by the Institute for Machine Tools and Industrial Management (iwb) at the Technical University of Munich, as it is acknowledged that mechanical changes are challenging to realize within industrial manufacturing facilities. Reconfigurability is realised through exploitation of data integration across the PPR domains, through the extension of the capabilities of a non-commercial virtual engineering toolset developed by the Automation Systems Group at the University of Warwick. The work shows an “end-to-end” approach that practically demonstrates the application of the flexibility and reconfigurability paradigms within an industrial engineering context

Nanosized Multifunctional Polyplexes for Receptor-Mediated SiRNA Delivery

Although our understanding of RNAi and our knowledge on designing and synthesizing active and safe siRNAs significantly increased during the past decade, targeted delivery remains the major limitation in the development of siRNA therapeutics. On one hand, practical considerations dictate robust chemistry reproducibly providing precise carrier molecules. On the other hand, the multistep delivery process requires dynamic multifunctional carriers of substantial complexity. We present a monodisperse and multifunctional carrier system, synthesized by solid phase supported chemistry, for siRNA delivery in vitro and in vivo. The sequence-defined assembly includes a precise cationic (oligoethanamino)amide core, terminated at the ends by two cysteines for bioreversible polyplex stabilization, at a defined central position attached to a monodisperse polyethylene glycol chain coupled to a terminal folic acid as cell targeting ligand. Complexation with an endosomolytic influenza peptide-siRNA conjugate results in nanosized functional polyplexes of 6 nm hydrodynamic diameter. The necessity of each functional substructure of the carrier system for a specific and efficient gene silencing was confirmed. The nanosized polyplexes showed stability in vivo, receptor-specific cell targeting, and silencing of the EG5 gene in receptor-positive tumors. The nanosized appearance of these particles can be precisely controlled by the oligomer design (from 5.8 to 8.8 nm diameter). A complete surface charge shielding together with the high stability result in good tolerability in vivo and the absence of accumulation in nontargeted tissues such as liver, lung, or spleen. Due to their small size, siRNA polyplexes are efficiently cleared by the kidney

Der kompetenzorientierte Unterricht in Mathematik in der österreichischen Volksschule aus Sicht der Schüler/innen: Impulse für eine reflexive Unterrichtsentwicklung und -forschung

Ziel von Schule und Unterricht ist die Förderung der Kompetenzentwicklung bei Kindern und Jugendlichen, wobei die grundgelegte Definition von Kompetenz sowohl kognitive Komponenten als auch volitionale, motivationale und soziale umfasst. Der vorliegende Beitrag widmet sich dem Unterricht als Kern des schulischen Geschehens und analysiert wesentliche Dimensionen kompetenzorientierten Unterrichts. Dabei werfen wir einen empirischen Blick auf die Dimensionen Aktivierung, Wissensvernetzung, lebensweltliche Anwendung, personalisierte sowie gruppenorientierte Lernbegleitung, Reflexion, Klassenmanagement und Klassenführung, in dem die aggregierten Wahrnehmungen von Volksschulkindern (Grundschulkindern) für eine Beschreibung des Mathematikunterrichts in Österreich in der Grundschule herangezogen werden. (DIPF/Orig.

Bacterial Infection Increases Periodontal Bone Loss in Diabetic Rats Through Enhanced Apoptosis

Periodontal disease is the most common osteolytic disease in humans and is significantly increased by diabetes mellitus. We tested the hypothesis that bacterial infection induces bone loss in diabetic animals through a mechanism that involves enhanced apoptosis. Type II diabetic rats were inoculated with Aggregatibacter actinomycetemcomitans and treated with a caspase-3 inhibitor, ZDEVD-FMK, or vehicle alone. Apoptotic cells were measured with TUNEL; osteoblasts and bone area were measured in H&E sections. New bone formation was assessed by labeling with fluorescent dyes and by osteocalcin mRNA levels. Osteoclast number, eroded bone surface, and new bone formation were measured by tartrate-resistant acid phosphatase staining. Immunohistochemistry was performed with an antibody against tumor necrosis factor-α. Bacterial infection doubled the number of tumor necrosis factor-α–expressing cells and increased apoptotic cells adjacent to bone 10-fold (P \u3c 0.05). Treatment with caspase inhibitor blocked apoptosis, increased the number of osteoclasts, and eroded bone surface (P \u3c 0.05); yet, inhibition of apoptosis resulted in significantly greater net bone area because of an increase in new bone formation, osteoblast numbers, and an increase in bone coupling. Thus, bacterial infection in diabetic rats stimulates periodontitis, in part through enhanced apoptosis of osteoblastic cells that reduces osseous coupling through a caspase-3–dependent mechanism. Diabetes is a chronic inflammatory disease characterized by hyperglycemia that affects 26 million Americans.1 Diabetes has several complications, such as cardiovascular, renal, microvascular, and periodontal diseases. Periodontal disease is one of the most common forms of osteolytic bone disease and one of the most frequent complications of the diabetes.2 Recent research suggests that the relationship between periodontitis and diabetes is reciprocal.3, 4 People with diabetes are more susceptible to periodontitis, and periodontitis may affect serum glucose levels and contribute to progression of diabetes.5 Diabetes may contribute to periodontitis because of its effect on inflammation.6, 7 Despite being triggered by bacterial infection, periodontal bone loss is tied to the inflammatory host response, which leads to the generation of prostaglandins and cytokines that stimulate osteoclastogenesis and periodontal bone loss.8 Several of the detrimental aspects of periodontal disease have recently been shown to be mediated by elevated levels of tumor necrosis factor-α (TNF-α).9, 10 TNF-α is a proinflammatory cytokine produced by leukocytes and other cell types.11 Enhanced TNF-α levels have been directly linked to cellular changes in diabetic retinopathy, deficits in wound healing, and diabetes-enhanced periodontitis.12, 13, 14 Some of the detrimental effects of diabetes-enhanced TNF-α levels may be because of the induction of cell death by triggering caspase activity. Caspases are a family of cysteine proteases that can act as either initiators (caspases 2, 8, and 9) or executioners (caspases 3, 6, and 7) of apoptosis.15 Caspase-3 appears to play a central role in bacteria and lipopolysaccharide-mediated apoptosis.16, 17 In addition, it has been shown that TNF-α can stimulate the expression of several pro-apoptotic genes, many of which are regulated by the pro-apoptotic transcription factor, forkhead box-O1 (FOXO1).18 The functional role of apoptosis in pathological processes can be studied with caspase inhibitors, which are small peptides that block the activity of well-defined caspases.19 These inhibitors have been used in animal models to attenuate cell death and diminish tissue damage in ischemic conditions, sepsis, and other pathological processes.20, 21 Other studies using caspase inhibitors have shown that part of the detrimental effect of diabetes on healing after infection is the result of increased fibroblast or osteoblast apoptosis.16, 22 To understand how diabetes may affect periodontal bone loss through apoptosis, we used a caspase-3/7 inhibitor in a type 2 Goto-Kakizaki (GK) diabetic rat model of periodontal disease induced by bacterial infection. The aim of this study was to determine how apoptosis of osteoblasts contributed to periodontal bone loss by its effect on bone formation in diabetic animals

High-Temperature Short-Time Treatment of Human Milk for Bacterial Count Reduction

Background: Human milk (HM) for preterm infants will often be pasteurized for cytomegalovirus (CMV) inactivation and reduction of its bacterial count. High-temperature short-time (HTST) treatment compared to standard Holder pasteurization (HoP) reduces the impact of heat treatment on bioactive HM proteins while effectively inactivating CMV. No data are available for the efficacy of bacterial count reduction using HTST treatments that are available for clinical use.Objective: To test the antiviral and antibacterial efficacy of HTST treatment protocols in HM using a modified HTST treatment device compared to standard HoP.Methods: Holder pasteurized 95 mL HM samples were inoculated with Staphylococcus aureus (ATCC 6538), Enterococcus faecalis (ATCC 29212), Pseudomonas aeruginosa (ATCC 27853), Serratia marcescens (Smarc 00697), two different strains of Klebsiella pneumoniae (ATCC 700603 and Kpn 01605) or spiked with 2 × 105 50% tissue culture infective dose of CMV (AD169) and subsequently subjected to HoP (62.5°C/30 min) or HTST treatment (62°C/5 s, 62°C/15 s, 72°C/5 s, 72°C/15 s, 87°C/2 s, and 87°C/5 s). Bacterial count was determined after treated HM was cultured for 24 h. CMV infectivity was determined by the number of specific CMV immediate early antigen stained nuclei after inoculating human fibroblasts with appropriately prepared HM samples.Results: Holder pasteurized samples revealed no growth after 24 h incubation. Viable bacterial cultures were retrieved from all tested strains after HTST treatment with the default HTST protocol (62°C/5 s) that is available for clinical use. Using other time-temperature combinations, growth rates of S. aureus, E. faecalis, P. aeruginosa, K. pneumoniae, K. pneumonia, and S. marcescens were depending on treatment time, treatment temperature, bacterial genera and strain. Only after treatment temperatures above 72°C no bacterial growth was observed. CMV was inactivated by any tested time-temperature combination.Conclusions: HTST treatment inactivates CMV in 95 mL HM samples but is less effective than HoP in bacterial count reduction at a time-temperature combination of 62°C/5 s. For a reliable bacterial count reduction HTST treatment at 87°C was required in this study