Distributed Contact and Identity Management

Contact management is a twofold problem involving a local and global level where the separation between them is rather fuzzy. Locally, users need to deal with contact management, which refers to a local need to store, organize, maintain up to date, and find information that will allow them contacting or reaching other people, organizations, etc. Globally, users deal with identity management that refers to peers having multiple identities (i.e., profiles) and the need of staying in control of them. In other words, they should be able to manage what information is shared and with whom. We believe many existing applications try to deal with this problem looking only at the data level and without analyzing the underlying complexity. Our approach focus on the complex social relations and interactions between users, identifying three main subproblem: (i) management of identity, (ii) search, and (iii) privacy. The solution we propose concentrates on the models that are needed to address these problems. In particular, we propose a Distributed Contact Management System (DCM System) that: Models and represents the knowledge of peers about physical or abstract objects through the notion of entities that can be of different types (e.g., locations, people, events, facilities, organizations, etc.) and are described by a set of attributes; By representing contacts as entities, allows peers to locally organize their contacts taking into consideration the semantics of the contact’s characteristics; By describing peers as entities allows them to manage their different identities in the network, by sharing different views of themselves (showing possibly different in- formation) with different people. The contributions of this thesis are, (i) the definition of a reference architecture that allows dealing with the diversity in relation with the partial view that peers have of the world, (ii) an approach to search entities based on identifiers, (iii) an approach to search entities based on descriptions, and (iv) the definition of the DCM system that instantiates the previously mentioned approaches and architecture to address concrete usage scenarios

3D printed plates based on generative design biomechanically outperform manual digital fitting and conventional systems printed in photopolymers in bridging mandibular bone defects of critical size in dogs

Conventional plate osteosynthesis of critical-sized bone defects in canine mandibles can fail to restore former functionality and stability due to adaption limits. Three-dimensional (3D) printed patient-specific implants are becoming increasingly popular as these can be customized to avoid critical structures, achieve perfect alignment to individual bone contours, and may provide better stability. Using a 3D surface model for the mandible, four plate designs were created and evaluated for their properties to stabilize a defined 30 mm critical-size bone defect. Design-1 was manually designed, and further shape optimized using Autodesk®Fusion 360 (ADF360) and finite element analysis (FE) to generate Design-2. Design-4 was created with the generative design (GD) function from ADF360 using preplaced screw terminals and loading conditions as boundaries. A 12-hole reconstruction titanium locking plate (LP) (2.4/3.0 mm) was also tested, which was scanned, converted to a STL file and 3D printed (Design-3). Each design was 3D printed from a photopolymer resin (VPW) and a photopolymer resin in combination with a thermoplastic elastomer (VPWT) and loaded in cantilever bending using a customized servo-hydraulic mechanical testing system; n = 5 repetitions each. No material defects pre- or post-failure testing were found in the printed mandibles and screws. Plate fractures were most often observed in similar locations, depending on the design. Design-4 has 2.8–3.6 times ultimate strength compared to other plates, even though only 40% more volume was used. Maximum load capacities did not differ significantly from those of the other three designs. All plate types, except D3, were 35% stronger when made of VPW, compared to VPWT. VPWT D3 plates were only 6% stronger. Generative design is faster and easier to handle than optimizing manually designed plates using FE to create customized implants with maximum load-bearing capacity and minimum material requirements. Although guidelines for selecting appropriate outcomes and subsequent refinements to the optimized design are still needed, this may represent a straightforward approach to implementing additive manufacturing in individualized surgical care. The aim of this work is to analyze different design techniques, which can later be used for the development of implants made of biocompatible materials

The Development of a Standardized Protocol for Quantifying Equestrian Eventing Cross-Country Ground

The ground has long been cited as a key contributing factor for injury risk in the cross-country phase of eventing. The current study aimed to develop a practically useful standardized protocol for measuring eventing cross country ground. Data collection was split into three phases: Phase 1 (Validation), Phase 2 (Expansion of data set), and Phase 3 (Threshold establishment). During Phase 1, data from nine event courses were collected using an Orono Biomechanical Surface Tester (OBST), Vienna Surface Tester (VST), Lang Penetrometer, Going Stick, and moisture meter. Using linear regression, 80% of the variability in cushioning measured with the OBST was predicted from moisture and VST measurements (p < 0.001). In Phase 2, objective data from 81 event courses and subjective assessments from 180 event riders were collected. In Phase 3, k-means cluster analysis was used to classify the courses into ten clusters based on average course measurements of moisture, cushioning, firmness, stiffness, depth, and coefficient of restitution. Based on cluster membership, course average subjective data (16 courses) were compared using a General Linear Model. Significant differences (p < 0.05) in subjective impact firmness (p = 0.038) and subjective cushioning (p = 0.010) were found between clusters. These data and cluster thresholds provide an event course baseline for future comparisons

Thoracic Electrical Impedance Tomography—The 2022 Veterinary Consensus Statement

Electrical impedance tomography (EIT) is a non-invasive real-time non-ionising imaging modality that has many applications. Since the first recorded use in 1978, the technology has become more widely used especially in human adult and neonatal critical care monitoring. Recently, there has been an increase in research on thoracic EIT in veterinary medicine. Real-time imaging of the thorax allows evaluation of ventilation distribution in anesthetised and conscious animals. As the technology becomes recognised in the veterinary community there is a need to standardize approaches to data collection, analysis, interpretation and nomenclature, ensuring comparison and repeatability between researchers and studies. A group of nineteen veterinarians and two biomedical engineers experienced in veterinary EIT were consulted and contributed to the preparation of this statement. The aim of this consensus is to provide an introduction to this imaging modality, to highlight clinical relevance and to include recommendations on how to effectively use thoracic EIT in veterinary species. Based on this, the consensus statement aims to address the need for a streamlined approach to veterinary thoracic EIT and includes: an introduction to the use of EIT in veterinary species, the technical background to creation of the functional images, a consensus from all contributing authors on the practical application and use of the technology, descriptions and interpretation of current available variables including appropriate statistical analysis, nomenclature recommended for consistency and future developments in thoracic EIT. The information provided in this consensus statement may benefit researchers and clinicians working within the field of veterinary thoracic EIT. We endeavor to inform future users of the benefits of this imaging modality and provide opportunities to further explore applications of this technology with regards to perfusion imaging and pathology diagnosis

Evaluation of three tidal volumes (10, 12 and 15 mL kg −1 ) in dogs for controlled mechanical ventilation assessed by volumetric capnography: a randomized clinical trial

OBJECTIVE: To evaluate three routinely used tidal volumes (VT; 10, 12 and 15 mL kg-1) for controlled mechanical ventilation (CMV) in lung-healthy anaesthetized dogs by assessing alveolar ventilation (VTalv) and dead space (DS). STUDY DESIGN: Prospective, randomized clinical trial. ANIMALS: A total of 36 client-owned dogs. METHODS: Dogs were randomly allocated to a VT of 10 (G10), 12 (G12) or 15 (G15) mL kg-1. After induction CMV was started. End-tidal carbon dioxide tension was maintained at 4.7-5.3 kPa by changing the respiratory frequency (fR; 6<fR<30 breaths minute-1). After 29 minutes, cardiovascular and respiratory variables were recorded for 3 minutes using a multiparameter monitor, volumetric capnography (VCap) and a blood gas analyser. The ratios of VTalv to body weight (VTalv kg-1) and airway DS to VT (VDaw/VT), Bohr's DS (VDBohr), Enghoff's DS (VDBE) and the volume of expired carbon dioxide per breath (VTCO2,br) were calculated. Mean airway pressure (MawP), fR and peak inspiratory pressure (PIP) were recorded. Data were analysed using one-way anova and Student-Newman-Keuls tests with a statistical significance set at p<0.05. RESULTS: No differences were observed for demographic data and cardiovascular variables between groups. A total of three dogs were excluded because of technical difficulties and one because of fR>30. VTalv kg-1 (p=0.001) increased and VDBohr (p=0.002) decreased with greater VT. VTCO2,br (p=0.017) increased and VDaw/VT (p=0.006), VDBE (p=0.008) and fR (p=0.002) decreased between G10 and G15. PIP (p=0.013) was significantly higher in G15 compared with that in G10 and G12. No changes were observed in MawP. CONCLUSIONS AND CLINICAL RELEVANCE: A VT of 15 mL kg-1 is most appropriate for CMV in lung-healthy dogs (as evaluated by respiratory mechanics and VCap) and does not impair cardiovascular variables

Evaluation of an Accelerometer-Based Device for Testing the Softness of Bedding Materials Used for Livestock

Lying is a high priority behavior for dairy cows. As the quality of cubicles can influence their lying time, the interest in finding objective methods to assess the quality of floors has increased substantially over recent decades. This study aimed to evaluate a technical device for measuring elastic properties of floors for the application to bedding materials for cows. Ten different floor types were used: horse manure, recycled manure solids, bark mulch, sand, sawdust, and three different rubber mats. Horse manure and bark mulch were additionally tested with chopped straw as a top layer. Two devices of the same kind and two examiners were available for performing comparative measurements. Regression analyses and an ANOVA were conducted to compare the devices, examiners, and different surfaces. Most of the floors differed significantly from each other. Sawdust was the softest material, followed by sand and recycled manure solids. The agreement between the devices (Lin&rsquo;s concordance correlation coefficient (CCC) &gt; 0.99, Spearman&rsquo;s rank correlation coefficient (rS) = 0.99) and examiners (CCC = 0.99, rS = 0.99) was almost perfect. These findings indicate that this device can be used as a new method for assessing the softness of bedding materials for dairy cows objectively

Custom made EIT electrode belt with 32 electrodes.

<p>(A) Each electrode comprised of 4 x 4 gold plated blunt pins with sufficient length to reach through the hair coat. (B) The electrodes did not cause any discomfort to conscious dogs.</p

Averaged functional EIT images showing the regression coefficient (Pearson R) for each pixel that significantly correlated with the reference respiratory signal.

<p>Pixels with red colour positively correlate with respiration (respiratory signals) but those with blue colour inversely correlate. Inverse respiratory signals occupy only a few pixels on the sides of the images and these are most likely artefacts. Unlike in horses, there is no indication that abdominal gas pockets would affect thoracic EIT images in dogs. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183340#pone.0183340.g001" target="_blank">Fig 1</a> for more explanation.</p

Comparison of respiratory function during TIVA and isoflurane anaesthesia in ponies, part II: breathing patterns and transdiaphragmatic pressure

Objective: To compare breathing patterns and transdiaphragmatic pressure during total intravenous (TIVA) and isoflurane anaesthesia in ponies. Study design: Experimental, cross-over study. Animals: Six healthy ponies weighing 286 (233-388)61kg, age 13 (9-16)3years. Methods: Following premedication with romifidine [80gkg(-1) intravenously (IV)], general anaesthesia was induced with midazolam (0.06mgkg(-1) IV) and ketamine (2.5mgkg(-1) IV) and maintained with either isoflurane (FeIso=1.1%) (T-ISO) or an IV combination of romifidine (120gkg(-1) per hour), midazolam (0.09mgkg(-1) hour(-1)) and ketamine (3.3mgkg(-1) hour(-1)) (T-TIVA), while breathing 60% oxygen (FIO2). The circumference changes of the rib cage (RC) and abdominal compartment (ABD) were recorded using respiratory ultrasonic plethysmography (RUP). Balloon tipped catheters were placed in the distal oesophagus and the stomach and maximal transdiaphragmatic pressure (P-di max) was calculated during Mueller's manoeuvre. Results: The breathing pattern T-ISO was more regular and respiratory rate significantly lower compared with T-TIVA. Ponies in T-TIVA showed regularly appearing sighs, which were never observed in T-ISO. Different contribution of the RC and ABD compartments to the breathing pattern was observed with a smaller participation of the RC to the total volume change during T-ISO. Transdiaphragmatic pressures (mean 13.7 +/- SD 8.61 versus 23.4 +/- 7.27 cmH(2)O, p<0.0001) were higher in T-TIVA compared to T-ISO. The sum of the RC and ABD circumferential changes was lower during T-TIVA compared to T-ISO (6.32 +/- 4.42 versus 11.72 +/- 4.38 units, p<0.0001). Conclusion and clinical relevance: Marked differences in breathing pattern and transdiaphragmatic pressure exist during inhalation- and TIVA and these should be taken into account for clinical estimation of anaesthetic depth

Physiologic Factors Influencing the Arterial-To-End-Tidal CO2 Difference and the Alveolar Dead Space Fraction in Spontaneously Breathing Anesthetised Horses

The arterial to end-tidal CO2 difference (P(a-ET)CO2) and alveolar dead space fraction (VDalvfrac = P(a-ET)CO2/PaCO2), are used to estimate Enghoff’s “pulmonary dead space” (V/QEng), a factor which is also influenced by venous admixture and other pulmonary perfusion abnormalities and thus is not just a measure of dead space as the name suggests. The aim of this experimental study was to evaluate which factors influence these CO2 indices in anesthetized spontaneously breathing horses. Six healthy adult horses were anesthetized in dorsal recumbency breathing spontaneously for 3 h. Data to calculate the CO2 indices (response variables) and dead space variables were measured every 30 min. Bohr’s physiological and alveolar dead space variables, cardiac output (CO), mean pulmonary pressure (MPP), venous admixture (Q˙s​/​Q˙t), airway dead space, tidal volume, oxygen consumption, and slope III of the volumetric capnogram were evaluated (explanatory variables). Univariate Pearson correlation was first explored for both CO2 indices before V/QEng and the explanatory variables with rho were reported. Multiple linear regression analysis was performed on P(a-ET)CO2 and VDalvfrac assessing which explanatory variables best explained the variance in each response. The simplest, best-fit model was selected based on the maximum adjusted R2 and smallest Mallow’s p (Cp). The R2 of the selected model, representing how much of the variance in the response could be explained by the selected variables, was reported. The highest correlation was found with the alveolar part of V/QEng to alveolar tidal volume ratio for both, P(a-ET)CO2 (r = 0.899) and VDalvfrac (r = 0.938). Venous admixture and CO best explained P(a-ET)CO2 (R2 = 0.752; Cp = 4.372) and VDalvfrac (R2 = 0.711; Cp = 9.915). Adding MPP (P(a-ET)CO2) and airway dead space (VDalvfrac) to the models improved them only marginally. No “real” dead space variables from Bohr’s equation contributed to the explanation of the variance of the two CO2 indices. P(a-ET)CO2 and VDalvfrac were closely associated with the alveolar part of V/QEng and as such, were also influenced by variables representing a dysfunctional pulmonary perfusion. Neither P(a-ET)CO2 nor VDalvfrac should be considered pulmonary dead space, but used as global indices of V/Q mismatching under the described conditions