Zur Bewertung von Niederdeutsch und lokalem Substandard in Hamburg

Based on the results of a quantitative study it is to be shown how Low German and forms of the Substandard of Hamburg are estimated within the population. The study was conducted within the context of the project Einstellungen gegenüber regionalen Sprachformen in der Großstadt: Niederdeutsch in Hamburg (NiH) (Attitudes towards regional languages in the city: Low German in Hamburg). The article takes a closer look at the connection between evaluation and social parameters such as age, language skills, origin and education. Finally, the potential differences in the evaluation between Low German and the vernacular Hamburg speech will be examined

The performance of hearing impaired children on the Revised Extended Griffiths Scales

In this unique time of nation building in South Africa, education is seen as the key foundation stone to prosperity and development. However, despite a decade of restructuring, many differing groups of children still do not receive the quality of education they deserve. Amongst those are children with special needs, including those who have a hearing impairment. These children are the focus of the present study. It is a widely accepted principle that early assessment and intervention is necessary to maximise a child’s potential. It is for this reason that the global aim of this study was to explore and describe the developmental profile of hearing impaired children on the Revised Extended Griffiths Scales. Further aims were to compare the performance of the clinical sample to a normal South African sample. A quantitative, exploratory-descriptive research design was employed. The sample of hearing impaired children (N = 58), between the ages of 36 and 95 months, attended the Carel du Toit Pre-School in the Western Cape, South Africa and were obtained by means of a non-probability, purposive sampling procedure. The normal sample (N = 58) was drawn from an existing database created for the revision of the Scales. Information was collated using clinical files, biographical data as well as the results of an assessment on the Revised Extended Griffiths Scales. The major findings of the study are summarised below. The general performance of the hearing impaired sample on the Revised Extended Griffiths Scales was average. The performance of the children on the six subscales ranged from below average to average, with major fall-outs occurring on the Hearing and Speech and Practical Reasoning Subscales. The normal sample performed significantly better than the hearing impaired sample on all of the subscales of the measure. However, significant differences were found on four of the six subscales, namely, the Locomotor, Personal-Social, Hearing and Speech and Practical Reasoning Subscales. Generally, the results of the current study suggest that a specific developmental profile is obtained for hearing impaired children. In addition, this study has highlighted the success with which the Revised Extended Griffiths Scales can be utilised on a hearing impaired population

Interval carcinomas in the European Randomized Study of Screening for Prostate Cancer (ERSPC)-Rotterdam

BACKGROUND: The interval cancer rate is an important parameter for determining the sensitivity of a screening procedure and the screening interval. We evaluated the time and mechanism of detection and the stage distribution of interval prostate cancers diagnosed during a 4-year screening interval. METHODS: We determined the rate of interval cancers and the sensitivity of the screening protocol (involving prostate-specific antigen, digital rectal and transrectal ultrasound examinations) in a cohort of 17 226 men (8350 on the screened arm, 8876 on the control arm) enrolled consecutively on the European Randomized Study of Screening for Prostate Cancer-Rotterdam. Men on the screened arm received a first screen between October 1993 and December 1996 and a scheduled second screen 4 years later. Prostate cancers detected in men enrolled on the control arm over the same 4-year period and, between screens, in men on the screened arm, were identified by linkage to the Dutch national cancer registry. RESULTS: During the first screen, 412 prostate cancers were detected. During the subsequent 4-year period, 135 cancers were diagnosed in men in the control arm and 25 cancers were diagnosed in men in the screened arm. Seven of the 25 cancers were diagnosed in men who had refused a recommended biopsy at their initial screen. Of the remaining 18 cancers, all were classified as stage T1A-C or T2A and none were poorly differentiated or metastatic. The rate of interval cancers relative to the number of cancers in the control group was 18.5% (25/135), or 13.3% (18/135), if the seven who refused an initial biopsy were excluded. The sensitivity of the screening protocol was 79.8% when considering all 25 interval cancers and 85.5% when considering 18 interval cancers. CONCLUSION: The interval cancer rate with a 4-year screening interval was low, confirming that the screening procedure has a high sensitivity and that the 4-year screening interval is reasonable

Unkrautbekämpfung in Mais - Der gezielte Einsatz von reduzierten Aufwandmengen herbizider Tankmischungen in Mais - ein Beitrag zur Umsetzung des integrierten Pflanzenschutzes in der landwirtschaftlichen Praxis - Ergebnisse von Ringversuchen der Länder Brandenburg, Sachsen, Sachsen-Anhalt und Thüringen in den Jahren 2004 - 2006

Der gezielte Einsatz von reduzierten Aufwandmengen herbizider Tankmischungen in Mais ein Beitrag zur Umsetzung des integrierten Pflanzenschutzes in der landwirtschaftlichen Praxis. Ergebnisse von Ringversuchen der Länder Brandenburg, Sachsen, Sachsen-Anhalt und Thüringen in den Jahren 2004 - 2006. Wie weit können die Aufwandmengen von praxisüblichen Tankmischungen reduziert werden, um einerseits noch eine ausreichende Breitenwirkung zu erzielen und andererseits aber auch die Unkrautarten zu ermitteln, bei denen bei einer Dosisverminderung ein deutlicher Wirkungsabfall zu verzeichnen ist? Im Rahmen des von der Politik geforderten Reduktionsprogramms chemischer Pflanzenschutz (BMELV 2004) steht auch bei der Unkrautbekämpfung im Mais die Frage nach dem unbedingt notwendigen Maß beim Einsatz der verschiedenen herbiziden Wirkstoffe

Skeletal muscle alterations in tachycardia-induced heart failure are linked to deficient natriuretic peptide signalling and are attenuated by RAS-/NEP-inhibition

Background Heart failure induced cachexia is highly prevalent. Insights into disease progression are lacking. Methods Early state of left ventricular dysfunction (ELVD) and symptomatic systolic heart failure (HF) were both induced in rabbits by tachypacing. Tissue of limb muscle (LM) was subjected to histologic assessment. For unbiased characterisation of early and late myopathy, a proteomic approach followed by computational pathway-analyses was performed and combined with pathway-focused gene expression analyses. Specimen of thoracic diaphragm (TD) served as control for inactivity-induced skeletal muscle alterations. In a subsequent study, inhibition of the renin-angiotensin-system and neprilysin (RAS-/NEP) was compared to placebo. Results HF was accompanied by loss of protein content (8.7±0.4% vs. 7.0±0.5%, mean±SEM, control vs. HF, p<0.01) and a slow-to-fast fibre type switch, establishing hallmarks of cachexia. In ELVD, the enzymatic set-up of LM and TD shifted to a catabolic state. A disturbed malate-aspartate shuttle went well with increased enzymes of glycolysis, forming the enzymatic basis for enforced anoxic energy regeneration. The histological findings and the pathway analysis of metabolic results drew the picture of suppressed PGC-1α signalling, linked to the natriuretic peptide system. In HF, natriuretic peptide signalling was desensitised, as confirmed by an increase in the ratio of serum BNP to tissue cGMP (57.0±18.6pg/ml/nM/ml vs. 165.8±16.76pg/ml/nM/ml, p<0.05) and a reduced expression of natriuretic peptide receptor-A. In HF, combined RAS-/NEP-inhibition prevented from loss in protein content (8.7±0.3% vs. 6.0±0.6% vs. 8.3±0.9%, Baseline vs. HF-Placebo vs. HF-RAS/NEP, p<0.05 Baseline vs. HF-Placebo, p = 0.7 Baseline vs. HF-RAS/NEP). Conclusions Tachypacing-induced heart failure entails a generalised myopathy, preceding systolic dysfunction. The characterisation of “pre-cachectic” state and its progression is feasible. Early enzymatic alterations of LM depict a catabolic state, rendering LM prone to futile substrate metabolism. A combined RAS-/NEP-inhibition ameliorates cardiac-induced myopathy independent of systolic function, which could be linked to stabilised natriuretic peptide/cGMP/PGC-1α signalling

Influence of mental health service provision on the perceived quality of life among psychiatric outpatients: associations and mediating factors

ObjectiveTo investigate the relationship between perceived mental health service provision and quality of life (QoL) as perceived by patients in psychiatric outpatient care.MethodsA total of 373 adult patients registered at 15 psychiatric outpatient clinics in three regions in central and southern Sweden were included in the study. Survey data were collected using a questionnaire on mental health service provision, symptom severity, recovery, clinical diagnosis, sociodemographics (serving as independent variables) and QoL (serving as the dependent variable). Three aspects of mental health service provision were used: patients’ perceived quality of care, perceived staff-patient interaction, and patient reported psychiatric treatments. Structural equation modelling was used to model the relationship among the variables.ResultsVariables in mental health service provision showed few direct associations with patients’ perceived QoL. Instead, the associations of mental health service provision on QoL were mainly mediated through symptom severity and recovery. These relationships were retained after adjusting for sociodemographic variables and clinical diagnoses. The final model achieved excellent goodness of fit (χ2 = 49.502, p = 0.230, RMSEA = 0.020, CFI = 0.997 and a SRMR = 0.024).ConclusionThis study shows that mental health service provision is associated with patients’ perceived QoL; however, this association is mostly indirect and mediated by reduced symptom severity and increased recovery. This finding can help inform the design of future interventions to enhance service provision to improve patients’ QoL

Lead times and overdetection due to prostate-specific antigen screening: estimates from the European Randomized Study of Screening for Prostate Cancer

BACKGROUND: Screening for prostate cancer advances the time of diagnosis (lead time) and detects cancers that would not have been diagnosed in the absence of screening (overdetection). Both consequences have considerable impact on the net benefits of screening. METHODS: We developed simulation models based on results of the Rotterdam section of the European Randomized Study of Screening for Prostate Cancer (ERSPC), which enrolled 42,376 men and in which 1498 cases of prostate cancer were identified, and on baseline prostate cancer incidence and stage distribution data. The models were used to predict mean lead times, overdetection rates, and ranges (corresponding to approximate 95% confidence intervals) associated with different screening programs. RESULTS: Mean lead times and rates of overdetection depended on a man's age at screening. For a single screening test at age 55, the estimated mean lead time was 12.3 years (range = 11.6-14.1 years) and the overdetection rate was 27% (range = 24%-37%); at age 75, the estimates were 6.0 years (range = 5.8-6.3 years) and 56% (range = 53%-61%), respectively. For a screening program with a 4-year screening interval from age 55 to 67, the estimated mean lead time was 11.2 years (range = 10.8-12.1 years), and the overdetection rate was 48% (range = 44%-55%). This screening program raised the lifetime risk of a prostate cancer diagnosis from 6.4% to 10.6%, a relative increase of 65% (range = 56%-87%). In annual screening from age 55 to 67, the estimated overdetection rate was 50% (range = 46%-57%) and the lifetime prostate cancer risk was increased by 80% (range = 69%-116%). Extending annual or quadrennial screening to the age of 75 would result in at least two cases of overdetection for every clinically relevant cancer detected. CONCLUSIONS: These model-based lead-time estimates support a prostate cancer screening interval of more than 1 year