6,623 research outputs found
Searching (the) FIRST radio arcs near ACO clusters
Gravitational lensing (GL) of distant radio sources by galaxy clusters should
produce radio arc(let)s. We extracted radio sources from the FIRST survey near
Abell cluster cores and found their radio position angles to be uniformly
distributed with respect to the cluster centres. This result holds even when we
restrict the sample to the richest or most centrally condensed clusters, and to
sources with high S/N and large axial ratio. Our failure to detect GL with
statistical methods may be due to poor cluster centre positions. We did not
find convincing candidates for arcs either. Our result agrees with theoretical
estimates predicting that surveys much deeper than FIRST are required to detect
the effect. This is in apparent conflict with the detection of such an effect
claimed by Bagchi & Kapahi (1995).Comment: 6 pages; 8 figures and 1 style file are included; to appear in Proc.
"Observational Cosmology with the New Radio Surveys", eds. M. Bremer, N.
Jackson & I. Perez-Fournon, Kluwer Acad. Pres
Identification of liver metastases with probe-based confocal laser endomicroscopy at two excitation wavelengths.
BACKGROUND: Metastasis of colorectal cancer to the liver is the most common indication for hepatic resection in a western population. Incomplete excision of malignancy due to residual microscopic disease normally results in worse patient outcome. Therefore, a method aiding in the real time discrimination of normal and malignant tissue on a microscopic level would be of benefit. MATERIAL AND METHODS: The ability of fluorescent probe-based confocal laser endomicroscopy (pCLE) to identify normal and malignant liver tissue was evaluated in an orthotopic murine model of colorectal cancer liver metastasis (CRLM). To maximise information yield, two clinical fluorophores, fluorescein and indocyanine green (ICG) were injected and imaged in a dual wavelength approach (488 and 660 nm, respectively). Visual tissue characteristics on pCLE examination were compared with histological features. Fluorescence intensity in both tissues was statistically analysed to elucidate if this can be used to differentiate between normal and malignant tissue. RESULTS: Fluorescein (488 nm) enabled good visualisation of normal and CRLM tissue, whereas ICG (660 nm) visualisation was limited to normal liver tissue only. Fluorescence intensity in areas of CRLM was typically 53-100% lower than normal hepatic parenchyma. Using general linear mixed modelling and receiver operating characteristic analysis, high fluorescence intensity was found to be statistically more likely in normal hepatic tissue. CONCLUSION: Real time discrimination between normal liver parenchyma and metastatic tissue with pCLE examination of fluorescein and ICG is feasible. Employing two (rather than a single) fluorophores allows a combination of qualitative and quantitative characteristics to be used to distinguish between hepatic parenchyma and CRLM. Lasers Surg. Med. © 2016 Wiley Periodicals, Inc
The Precursors and Products of Justice Climates: Group Leader Antecedents and Employee Attitudinal Consequences
Drawing on the organizational justice, organizational climate, leadership and personality, and social comparison theory literatures, we develop hypotheses about the effects of leader personality on the development of three types of justice climates (e.g., procedural, interpersonal, and informational), and the moderating effects of these climates on individual level justice- attitude relationships. Largely consistent with the theoretically-derived hypotheses, the results showed that leader (a) agreeableness was positively related to procedural, interpersonal and informational justice climates, (b) conscientiousness was positively related to a procedural justice climate, and (c) neuroticism was negatively related to all three types of justice climates. Further, consistent with social comparison theory, multilevel data analyses revealed that the relationship between individual justice perceptions and job attitudes (e.g., job satisfaction, commitment) was moderated by justice climate such that the relationships were stronger when justice climate was high
The substantive and practical significance of citation impact differences between institutions: Guidelines for the analysis of percentiles using effect sizes and confidence intervals
In our chapter we address the statistical analysis of percentiles: How should
the citation impact of institutions be compared? In educational and
psychological testing, percentiles are already used widely as a standard to
evaluate an individual's test scores - intelligence tests for example - by
comparing them with the percentiles of a calibrated sample. Percentiles, or
percentile rank classes, are also a very suitable method for bibliometrics to
normalize citations of publications in terms of the subject category and the
publication year and, unlike the mean-based indicators (the relative citation
rates), percentiles are scarcely affected by skewed distributions of citations.
The percentile of a certain publication provides information about the citation
impact this publication has achieved in comparison to other similar
publications in the same subject category and publication year. Analyses of
percentiles, however, have not always been presented in the most effective and
meaningful way. New APA guidelines (American Psychological Association, 2010)
suggest a lesser emphasis on significance tests and a greater emphasis on the
substantive and practical significance of findings. Drawing on work by Cumming
(2012) we show how examinations of effect sizes (e.g. Cohen's d statistic) and
confidence intervals can lead to a clear understanding of citation impact
differences
Mutation of the parkinsonism gene ATP13A2 causes neuronal ceroid-lipofuscinosis
Neuronal ceroid lipofuscinoses (NCLs) comprise a heterogeneous group of metabolic storage diseases that present with the accumulation of autofluorescent lipopigment, neurodegeneration and premature death. Nine genes have been thus far identified as the cause of different types of NCL, with ages at onset ranging from around birth to adult, although the underlying etiology of the disease still remains elusive. We present a family with typical NCL pathology in which we performed exome sequencing and identified a single homozygous mutation in ATP13A2 that fully segregates with disease within the family. Mutations in ATP13A2 are a known cause of Kufor-Rakeb syndrome (KRS), a rare parkinsonian phenotype with juvenile onset. These data show that NCL and KRS may share etiological features and implicate the lysosomal pathway in Parkinson's disease
Semaphorin 6A Improves Functional Recovery in Conjunction with Motor Training after Cerebral Ischemia
Background: We have previously identified Semaphorin 6a (Sema6A) as an upregulated gene product in a gene expression screen in cortical ischemia [1]. Semaphorin 6a was regulated during the recovery phase following ischemia in the cortex. Semaphorin 6a is a member of the superfamily of semaphorins involved in axon guidance and other functions. We hypothesized that the upregulation indicates a crucial role of this molecule in post-stroke rewiring of the brain. Here we have tested this hypothesis by overexpressing semaphorin 6a in the cortex by microinjection of a modified AAV2-virus. A circumscribed cortical infarct was induced, and the recovery of rats monitored for up to 4 weeks using a well-established test battery (accelerated rotarod training paradigm, cylinder test, adhesive tape removal). We observed a significant improvement in post-ischemic recovery of animals injected with the semaphorin 6a virus versus animals treated with a control virus. We conclude that semaphorin 6a overexpressed in the cortex enhances recovery after cerebral ischemia
Rapid assessment of myocardial infarct size in rodents using multi-slice inversion recovery late gadolinium enhancement CMR at 9.4T
Background: Myocardial infarction (MI) can be readily assessed using late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR). Inversion recovery (IR) sequences provide the highest contrast between enhanced infarct areas and healthy myocardium. Applying such methods to small animals is challenging due to rapid respiratory and cardiac rates relative to T-1 relaxation.Methods: Here we present a fast and robust protocol for assessing LGE in small animals using a multi-slice IR gradient echo sequence for efficient assessment of LGE. An additional Look-Locker sequence was used to assess the optimum inversion point on an individual basis and to determine most appropriate gating points for both rat and mouse. The technique was applied to two preclinical scenarios: i) an acute (2 hour) reperfused model of MI in rats and ii) mice 2 days following non-reperfused MI.Results: LGE images from all animals revealed clear areas of enhancement allowing for easy volume segmentation. Typical inversion times required to null healthy myocardium in rats were between 300-450 ms equivalent to 2-3 R-waves and similar to 330 ms in mice, typically 3 R-waves following inversion. Data from rats was also validated against triphenyltetrazolium chloride staining and revealed close agreement for infarct size.Conclusion: The LGE protocol presented provides a reliable method for acquiring images of high contrast and quality without excessive scan times, enabling higher throughput in experimental studies requiring reliable assessment of MI
Neural correlates of enhanced visual short-term memory for angry faces: An fMRI study
Copyright: © 2008 Jackson et al.Background: Fluid and effective social communication requires that both face identity and emotional expression information are encoded and maintained in visual short-term memory (VSTM) to enable a coherent, ongoing picture of the world and its players. This appears to be of particular evolutionary importance when confronted with potentially threatening displays of emotion - previous research has shown better VSTM for angry versus happy or neutral face identities.Methodology/Principal Findings: Using functional magnetic resonance imaging, here we investigated the neural correlates of this angry face benefit in VSTM. Participants were shown between one and four to-be-remembered angry, happy, or neutral faces, and after a short retention delay they stated whether a single probe face had been present or not in the previous display. All faces in any one display expressed the same emotion, and the task required memory for face identity. We find enhanced VSTM for angry face identities and describe the right hemisphere brain network underpinning this effect, which involves the globus pallidus, superior temporal sulcus, and frontal lobe. Increased activity in the globus pallidus was significantly correlated with the angry benefit in VSTM. Areas modulated by emotion were distinct from those modulated by memory load.Conclusions/Significance: Our results provide evidence for a key role of the basal ganglia as an interface between emotion and cognition, supported by a frontal, temporal, and occipital network.The authors were supported by a Wellcome Trust grant (grant number 077185/Z/05/Z) and by BBSRC (UK) grant BBS/B/16178
Solving integral equations in
A dispersive analysis of decays has been performed in the past
by many authors. The numerical analysis of the pertinent integral equations is
hampered by two technical difficulties: i) The angular averages of the
amplitudes need to be performed along a complicated path in the complex plane.
ii) The averaged amplitudes develop singularities along the path of integration
in the dispersive representation of the full amplitudes. It is a delicate
affair to handle these singularities properly, and independent checks of the
obtained solutions are demanding and time consuming. In the present article, we
propose a solution method that avoids these difficulties. It is based on a
simple deformation of the path of integration in the dispersive representation
(not in the angular average). Numerical solutions are then obtained rather
straightforwardly. We expect that the method also works for .Comment: 11 pages, 10 Figures. Version accepted for publication in EPJC. The
ancillary files contain an updated set of fundamental solutions. The
numerical differences to the former set are tiny, see the READMEv2 file for
detail
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