6,743 research outputs found
Can Christianity Engage Consumer Capitalism?
Dr. Schneider developed this paper from a pair of lectures delivered on March 8, 2004, at the Dordt College Science and Technology Center
A hybrid computer study of a dynamic ship positioning system
Hybrid computer program for dynamic ship positioning syste
Report by the ESA-ESO Working Group on Fundamental Cosmology
ESO and ESA agreed to establish a number of Working Groups to explore
possible synergies between these two major European astronomical institutions.
This Working Group's mandate was to concentrate on fundamental questions in
cosmology, and the scope for tackling these in Europe over the next ~15 years.
One major resulting recommendation concerns the provision of new generations of
imaging survey, where the image quality and near-IR sensitivity that can be
attained only in space are naturally matched by ground-based imaging and
spectroscopy to yield massive datasets with well-understood photometric
redshifts (photo-z's). Such information is essential for a range of new
cosmological tests using gravitational lensing, large-scale structure, clusters
of galaxies, and supernovae. Great scope in future cosmology also exists for
ELT studies of the intergalactic medium and space-based studies of the CMB and
gravitational waves; here the synergy is less direct, but these areas will
remain of the highest mutual interest to the agencies. All these recommended
facilities will produce vast datasets of general applicability, which will have
a tremendous impact on broad areas of astronomy.Comment: ESA-ESO Working Groups Report No. 3, 125 pages, 28 figures. A PDF
version including the cover is available from
http://www.stecf.org/coordination/esa_eso/cosmology/report_cover.pdf and a
printed version (A5 booklet) is available in limited numbers from the Space
Telescope-European Coordinating Facility (ST-ECF): [email protected]
Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer.
Bone density is controlled by interactions between osteoclasts, which resorb bone, and osteoblasts, which deposit it. The semaphorins and their receptors, the plexins, originally shown to function in the immune system and to provide chemotactic cues for axon guidance, are now known to play a role in this process as well. Emerging data have identified Semaphorin 4D (Sema4D) as a product of osteoclasts acting through its receptor Plexin-B1 on osteoblasts to inhibit their function, tipping the balance of bone homeostasis in favor of resorption. Breast cancers and other epithelial malignancies overexpress Sema4D, so we theorized that tumor cells could be exploiting this pathway to establish lytic skeletal metastases. Here, we use measurements of osteoblast and osteoclast differentiation and function in vitro and a mouse model of skeletal metastasis to demonstrate that both soluble Sema4D and protein produced by the breast cancer cell line MDA-MB-231 inhibits differentiation of MC3T3 cells, an osteoblast cell line, and their ability to form mineralized tissues, while Sema4D-mediated induction of IL-8 and LIX/CXCL5, the murine homologue of IL-8, increases osteoclast numbers and activity. We also observe a decrease in the number of bone metastases in mice injected with MDA-MB-231 cells when Sema4D is silenced by RNA interference. These results are significant because treatments directed at suppression of skeletal metastases in bone-homing malignancies usually work by arresting bone remodeling, potentially leading to skeletal fragility, a significant problem in patient management. Targeting Sema4D in these cancers would not affect bone remodeling and therefore could elicit an improved therapeutic result without the debilitating side effects
Anachronistic Grain Growth and Global Structure of the Protoplanetary Disk Associated with the Mature Classical T Tauri Star, PDS 66
We present ATCA interferometric observations of the old (13 Myr), nearby
(86pc) classical T Tauri star, PDS 66. Unresolved 3 and 12 mm continuum
emission is detected towards PDS 66, and upper limits are derived for the 3 and
6 cm flux densities. The mm-wave data show a spectral slope flatter than that
expected for ISM-sized dust particles, which is evidence of grain growth. We
also present HST/NICMOS 1.1 micron PSF-subtracted coronagraphic imaging of PDS
66. The HST observations reveal a bilaterally symmetric circumstellar region of
dust scattering about 0.32% of the central starlight, declining radially in
surface brightness. The light-scattering disk of material is inclined 32
degrees from face-on, and extends to a radius of 170 AU. These data are
combined with published optical and longer wavelength observations to make
qualitative comparisons between the median Taurus and PDS 66 spectral energy
distributions (SEDs). By comparing the near-infrared emission to a simple
model, we determine that the location of the inner disk radius is consistent
with the dust sublimation radius (1400 K at 0.1 AU). We place constraints on
the total disk mass using a flat-disk model and find that it is probably too
low to form gas giant planets according to current models. Despite the fact
that PDS 66 is much older than a typical classical T Tauri star (< 5 Myr), its
physical properties are not much different.Comment: 31 pages, 7 figure
Multi-wavelength modeling of the spatially resolved debris disk of HD 107146
(abridged) We aim to constrain the location, composition, and dynamical state
of planetesimal populations and dust around the young, sun-like (G2V) star HD
107146}. We consider coronagraphic observations obtained with the Advanced
Camera for Surveys (HST/ACS) onboard the HST in broad V and broad I filters, a
resolved 1.3mm map obtained with the Combined Array for Research in
Millimeter-Wave Astronomy (CARMA), Spitzer/IRS low resolution spectra, and the
spectral energy distribution (SED) of the object at wavelengths ranging from
3.5micron to 3.1mm. We complement these data with new coronagraphic high
resolution observations of the debris disk using the Near Infrared Camera and
Multi-Object Spectrometer (HST/NICMOS) aboard the HST in the F110W filter. The
SED and images of the disk in scattered light as well as in thermal reemission
are combined in our modeling using a parameterized model for the disk density
distribution and optical properties of the dust. A detailed analytical model of
the debris disk around HD 107146 is presented that allows us to reproduce the
almost entire set of spatially resolved and unresolved multi-wavelength
observations. Considering the variety of complementary observational data, we
are able to break the degeneracies produced by modeling SED data alone. We find
the disk to be an extended ring with a peak surface density at 131AU.
Furthermore, we find evidence for an additional, inner disk probably composed
of small grains released at the inner edge of the outer disk and moving inwards
due to Poynting-Robertson drag. A birth ring scenario (i.e., a more or less
broad ring of planetesimals creating the dust disk trough collisions) is found
to be the most likely explanation of the ringlike shape of the disk.Comment: 15 pages, 9 figures, accepted for publication in A&
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