536 research outputs found
Energy Distribution of Micro-events in the Quiet Solar Corona
Recent imaging observations of EUV line emissions have shown evidence for
frequent flare-like events in a majority of the pixels in quiet regions of the
solar corona. The changes in coronal emission measure indicate impulsive
heating of new material to coronal temperatures. These heating or evaporation
events are candidate signatures of "nanoflares" or "microflares" proposed to
interpret the high temperature and the very existence of the corona. The energy
distribution of these micro-events reported in the literature differ widely,
and so do the estimates of their total energy input into the corona. Here we
analyze the assumptions of the different methods, compare them by using the
same data set and discuss their results.
We also estimate the different forms of energy input and output, keeping in
mind that the observed brightenings are most likely secondary phenomena. A
rough estimate of the energy input observed by EIT on the SoHO satellite is of
the order of 10% of the total radiative output in the same region. It is
considerably smaller for the two reported TRACE observations. The discrepancy
can be explained partially by different thresholds for flare detection. There
is agreement on the slope and the absolute value of the distribution if the
same method were used and a numerical error corrected. The extrapolation of the
power law to unobserved energies that are many orders of magnitude smaller
remains questionable. Nevertheless, these micro-events and unresolved smaller
events are currently the best source of information on the heating process of
the corona
The Heavy Element Enrichment of Lyman alpha Clouds in the Virgo Supercluster
Using high S/N STIS echelle spectra (FWHM=7 km/s) of 3C 273, we constrain the
metallicities of two Lya clouds in the vicinity of the Virgo cluster. We detect
C II, Si II, and Si III absorption lines in the Lya absorber at z = 0.00530.
Previous observations with FUSE have revealed Ly beta - Ly theta lines at this
redshift, thereby accurately constraining N(H I). We model the ionization of
the gas and derive [C/H] = -1.2^{+0.3}_{-0.2}, [Si/C] = 0.2+/-0.1, and log
n_{H} = -2.8+/-0.3. The model implies a small absorber thickness, ~70 pc, and
thermal pressure p/k ~ 40 cm^{-3} K. It is most likely that the absorber is
pressure confined by an external medium because gravitational confinement would
require a very high ratio of dark matter to baryonic matter. Based on Milky Way
sight lines in which carbon and silicon abundances have been reliably measured
in the same interstellar cloud (including new measurements presented herein),
we argue that the overabundance of Si relative to C is not due to dust
depletion. Instead, this probably indicates that the gas has been predominately
enriched by Type II supernovae. Such enrichment is most plausibly provided by
an unbound galactic wind, given the absence of galaxies within a projected
distance of 100 kpc and the presence of galaxies capable of driving a wind at
larger distances. We also constrain the metallicity and physical conditions of
the Virgo absorber at z = 0.00337 based on detections of O VI and H I and an
upper limit on C IV. If this absorber is collisionally ionized, the O VI/C IV
limit requires T > 10^{5.3} K. For either collisional ionization or
photoionization, we find that [O/H] > -2.0 at z = 0.00337.Comment: Final Ap.J. versio
Composition Dependence of the Structure and Electronic Properties of Liquid Ga-Se Alloys Studied by Ab Initio Molecular Dynamics Simulation
Ab initio molecular dynamics simulation is used to study the structure and
electronic properties of the liquid Ga-Se system at the three compositions
GaSe, GaSe and GaSe, and of the GaSe and GaSe crystals. The
calculated equilibrium structure of GaSe crystal agrees well with available
experimental data. The neutron-weighted liquid structure factors calculated
from the simulations are in reasonable agreement with recent neutron
diffraction measurements. Simulation results for the partial radial
distribution functions show that the liquid structure is closely related to
that of the crystals. A close similarity between solid and liquid is also found
for the electronic density of states and charge density. The calculated
electronic conductivity decreases strongly with increasing Se content, in
accord with experimental measurements.Comment: REVTeX, 8 pages and 12 uuencoded PostScript figures, submitted to
Phys. Rev. B. corresponding author: [email protected]
The HST Quasar Absorption Line Key Project XII. The Unusual Absorption Line System in the Spectrum of PG 2302+029 ---Ejected or Intervening?
We report the discovery of a high-ionization broad absorption line system at
a redshift of z_abs=0.695 in the spectrum of the z_em=1.052 radio-quiet quasar
PG 2302+039. Broad absorption with FWHM from 3,000 to 5,000 km/s is detected
from C IV, N V, and O VI in HST Faint Object Spectrograph spectra of the
quasar. A narrow line system (FWHM approximately 250 km/s) at z_abs=0.7016 is
resolved from the broad blend and includes absorption by Ly-alpha and the C IV,
N V, and O VI doublets. No absorption by low-ionization metal species (e.g. Si
II and Mg II) is detected in the HST or ground-based spectra for either the
broad or the narrow system. The centroids of the broad system lines are
displaced by approximately 56,000 km/s to the blue of the quasar's broad
emission lines. The reddest extent of the broad line absorption is more than
50,000 km/s from the quasar. The properties of this system are unprecedented
whether it is an intervening or an ejected system.Comment: 9 pages, LaTeX file, two postscript figures. Accepted for publication
in The Astrophysical Journal Letters. Changes include removing TeX macros
from abstrac
Exclusion of a major role for the PTEN tumour-suppressor gene in breast carcinomas
PTEN is a novel tumour-suppressor gene located on chromosomal band 10q23.3. This region displays frequent loss of heterozygosity (LOH) in a variety of human neoplasms including breast carcinomas. The detection of PTEN mutations in Cowden disease and in breast carcinoma cell lines suggests that PTEN may be involved in mammary carcinogenesis. We here report a mutational analysis of tumour specimens from 103 primary breast carcinomas and constitutive DNA from 25 breast cancer families. The entire coding region of PTEN was screened by single-strand conformation polymorphism (SSCP) analysis and direct sequencing using intron-based primers. No germline mutations could be identified in the breast cancer families and only one sporadic carcinoma carried a PTEN mutation at one allele. In addition, all sporadic tumours were analysed for homozygous deletions by differential polymerase chain reaction (PCR) and for allelic loss using the microsatellite markers D10S215, D10S564 and D10S573. No homozygous deletions were detected and only 10 out of 94 informative tumours showed allelic loss in the PTEN region. These results suggest that PTEN does not play a major role in breast cancer formation. 1999 Cancer Research Campaig
Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers
Background: Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk. Several of these are also associated with risk of BC or OC for women who carry a pathogenic mutation in the high-risk BC and OC genes BRCA1 or BRCA2. The combined effects of these variants on BC or OC risk for BRCA1 and BRCA2 mutation carriers have not yet been assessed while their clinical management could benefit from improved personalized risk estimates.
Methods: We constructed polygenic risk scores (PRS) using BC and OC susceptibility SNPs identified through population-based GWAS: for BC (overall, estrogen receptor [ER]-positive, and ER-negative) and for OC. Using data from 15 252 female BRCA1 and 8211 BRCA2 carriers, the association of each PRS with BC or OC risk was evaluated using a weighted cohort approach, with time to diagnosis as the outcome and estimation of the hazard ratios (HRs) per standard deviation increase in the PRS.
Results: The PRS for ER-negative BC displayed the strongest association with BC risk in BRCA1 carriers (HR = 1.27, 95% confidence interval [CI] = 1.23 to 1.31, P = 8.2 x 10(53)). In BRCA2 carriers, the strongest association with BC risk was seen for the overall BC PRS (HR = 1.22, 95% CI = 1.17 to 1.28, P = 7.2 x 10(-20)). The OC PRS was strongly associated with OC risk for both BRCA1 and BRCA2 carriers. These translate to differences in absolute risks (more than 10% in each case) between the top and bottom deciles of the PRS distribution; for example, the OC risk was 6% by age 80 years for BRCA2 carriers at the 10th percentile of the OC PRS compared with 19% risk for those at the 90th percentile of PRS.
Conclusions: BC and OC PRS are predictive of cancer risk in BRCA1 and BRCA2 carriers. Incorporation of the PRS into risk prediction models has promise to better inform decisions on cancer risk management
Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high risk, early breast cancer.
BACKGROUND: The randomized, double-blind OlympiA trial compared one year of the oral poly(adenosine diphosphate-ribose) polymerase) inhibitor, olaparib, to matching placebo as adjuvant therapy for patients with pathogenic or likely pathogenic variants in germline BRCA1 or BRCA2 (gBRCA1/2pv) and high-risk, human epidermal growth factor receptor 2 (HER2)-negative, early breast cancer (EBC). The first pre-specified interim analysis (IA) previously demonstrated statistically significant improvement in invasive-disease-free survival (IDFS) and distant-disease-free survival (DDFS). The olaparib-group had fewer deaths than the placebo-group, but the difference did not reach statistical significance for overall survival (OS). We now report the pre-specified second IA of OS with updates of IDFS, DDFS, and safety. PATIENTS AND METHODS: 1,836 patients were randomly assigned to olaparib or placebo following (neo)adjuvant chemotherapy (N)ACT, surgery, and radiation therapy if indicated. Endocrine therapy was given concurrently with study medication for hormone-receptor-positive-cancers. Statistical significance for OS at this IA required P<0.015. RESULTS: With median follow-up of 3.5 years, the second IA of OS demonstrated significant improvement in the olaparib-group relative to the placebo-group (HR, 0.68; 98.5% CI 0.47 to 0.97; P=0.009). Four-year OS was 89.8% in the olaparib-group and 86.4% in the placebo-group (Δ 3.4%, 95% CI -0.1% to 6.8%). Four-year IDFS for olaparib-group versus placebo-group was 82.7% versus 75.4% (Δ 7.3%, 95% CI 3.0% to 11.5%) and 4-year DDFS was 86.5% versus 79.1% (Δ 7.4%, 95% CI 3.6% to 11.3%), respectively. Subset analyses for OS, IDFS, and DDFS demonstrated benefit across major subgroups. No new safety signals were identified including no new cases of acute myelogenous leukemia or myelodysplastic syndrome (AML/MDS). CONCLUSION: With 3.5 years of median follow-up, OlympiA demonstrates statistically significant improvement in OS with adjuvant olaparib compared with placebo for gBRCA1/2pv-associated EBC and maintained improvements in the previously reported, statistically significant endpoints of IDFS and DDFS with no new safety signals
Self-consistent Coronal Heating and Solar Wind Acceleration from Anisotropic Magnetohydrodynamic Turbulence
We present a series of models for the plasma properties along open magnetic
flux tubes rooted in solar coronal holes, streamers, and active regions. These
models represent the first self-consistent solutions that combine: (1)
chromospheric heating driven by an empirically guided acoustic wave spectrum,
(2) coronal heating from Alfven waves that have been partially reflected, then
damped by anisotropic turbulent cascade, and (3) solar wind acceleration from
gradients of gas pressure, acoustic wave pressure, and Alfven wave pressure.
The only input parameters are the photospheric lower boundary conditions for
the waves and the radial dependence of the background magnetic field along the
flux tube. For a single choice for the photospheric wave properties, our models
produce a realistic range of slow and fast solar wind conditions by varying
only the coronal magnetic field. Specifically, a 2D model of coronal holes and
streamers at solar minimum reproduces the latitudinal bifurcation of slow and
fast streams seen by Ulysses. The radial gradient of the Alfven speed affects
where the waves are reflected and damped, and thus whether energy is deposited
below or above the Parker critical point. As predicted by earlier studies, a
larger coronal ``expansion factor'' gives rise to a slower and denser wind,
higher temperature at the coronal base, less intense Alfven waves at 1 AU, and
correlative trends for commonly measured ratios of ion charge states and
FIP-sensitive abundances that are in general agreement with observations. These
models offer supporting evidence for the idea that coronal heating and solar
wind acceleration (in open magnetic flux tubes) can occur as a result of wave
dissipation and turbulent cascade. (abridged abstract)Comment: 32 pages (emulateapj style), 18 figures, ApJ Supplement, in press (v.
171, August 2007
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