11,478 research outputs found
Sub shot noise phase quadrature measurement of intense light beams
We present a setup to perform sub shot noise measurements of the phase
quadrature for intense pulsed light without the use of a separate local
oscillator. A Mach--Zehnder interferometer with an unbalanced arm length is
used to detect the fluctuations of the phase quadrature at a single side band
frequency. Using this setup, the non--separability of a pair of quadrature
entangled beams is demonstrated experimentally.Comment: 9 pages, 2 figures, accepted for publication in Optics Letter
Proteogenomics analysis of CUG codon translation in the human pathogen Candida albicans
Abstract Background: Yeasts of the CTG-clade lineage, which includes the human-infecting Candida albicans, Candida parapsilosis and Candida tropicalis species, are characterized by an altered genetic code. Instead of translating CUG codons as leucine, as happens in most eukaryotes, these yeasts, whose ancestors are thought to have lost the relevant leucine-tRNA gene, translate CUG codons as serine using a serine-tRNA with a mutated anticodon, tRNASer CAG . Previously reported experiments have suggested that 3â5% of the CTG-clade CUG codons are mistranslated as leucine due to mischarging of the tRNA Ser CAG . The mistranslation was suggested to result in variable surface proteins explaining fast host adaptation and pathogenicity. Results: In this study, we reassess this potential mistranslation by high-resolution mass spectrometry-based proteogenomics of multiple CTG-clade yeasts, including various C. albicans strains, isolated from colonized and from infected human body sites, and C. albicans grown in yeast and hyphal forms. Our data do not support a bias towards CUG codon mistranslation as leucine. Instead, our data suggest that (i) CUG codons are mistranslated at a frequency corresponding to the normal extent of ribosomal mistranslation with no preference for specific amino acids, (ii) CUG codons are as unambiguous (or ambiguous) as the related CUU leucine and UCC serine codons, (iii) tRNA anticodon loop variation across the CTG-clade yeasts does not result in any difference of the mistranslation level, and (iv) CUG codon unambiguity is independent of C. albicansâ strain pathogenicity or growth form. Conclusions: Our findings imply that C. albicans does not decode CUG ambiguously. This suggests that the proposed misleucylation of the tRNA Ser CAG might be as prevalent as every other misacylation or mistranslation event and, if at all, be just one of many reasons causing phenotypic diversity
Generic Multifractality in Exponentials of Long Memory Processes
We find that multifractal scaling is a robust property of a large class of
continuous stochastic processes, constructed as exponentials of long-memory
processes. The long memory is characterized by a power law kernel with tail
exponent , where . This generalizes previous studies
performed only with (with a truncation at an integral scale), by
showing that multifractality holds over a remarkably large range of
dimensionless scales for . The intermittency multifractal coefficient
can be tuned continuously as a function of the deviation from 1/2 and of
another parameter embodying information on the short-range amplitude
of the memory kernel, the ultra-violet cut-off (``viscous'') scale and the
variance of the white-noise innovations. In these processes, both a viscous
scale and an integral scale naturally appear, bracketing the ``inertial''
scaling regime. We exhibit a surprisingly good collapse of the multifractal
spectra on a universal scaling function, which enables us to derive
high-order multifractal exponents from the small-order values and also obtain a
given multifractal spectrum by different combinations of and
.Comment: 10 pages + 9 figure
Polaronic metal state at the LaAlO3/SrTiO3 interface
Interplay of spin, charge, orbital and lattice degrees of freedom in oxide
heterostructures results in a plethora of fascinating properties, which can be
exploited in new generations of electronic devices with enhanced
functionalities. The paradigm example is the interface between the two band
insulators LaAlO3 and SrTiO3 (LAO/STO) that hosts two-dimensional electron
system (2DES). Apart from the mobile charge carriers, this system exhibits a
range of intriguing properties such as field effect, superconductivity and
ferromagnetism, whose fundamental origins are still debated. Here, we use
soft-X-ray angle-resolved photoelectron spectroscopy to penetrate through the
LAO overlayer and access charge carriers at the buried interface. The
experimental spectral function directly identifies the interface charge
carriers as large polarons, emerging from coupling of charge and lattice
degrees of freedom, and involving two phonons of different energy and thermal
activity. This phenomenon fundamentally limits the carrier mobility and
explains its puzzling drop at high temperatures
Multipolar Interactions in the Anderson Lattice with Orbital Degeneracy
Microscopic investigation is performed for intersite multipolar interactions
in the orbitally degenerate Anderson lattice, with CeB taken as an
exemplary target. In addition to the intermediate state,
Hund's-rule ground states are included as intermediate states for the
interactions. The conduction-band states are taken as plane waves and the
hybridization as spherically symmetric. The spatial dependences of multipolar
interactions are given by the relative weight of partial wave components along
the pair of sites. It is clarified how the the anisotropy arises in the
interactions depending on the orbital degeneracy and the spatial configuration.
The stability of the antiferro-quadrupole order in the phase II of
CeB is consistent with our model. Moreover, the pseudo-dipole interactions
follow a tendency required by the phenomenological model for the phase III.Comment: 30 pages, 4 figure
Anomalies and the chiral magnetic effect in the Sakai-Sugimoto model
In the chiral magnetic effect an imbalance in the number of left- and
right-handed quarks gives rise to an electromagnetic current parallel to the
magnetic field produced in noncentral heavy-ion collisions. The chiral
imbalance may be induced by topologically nontrivial gluon configurations via
the QCD axial anomaly, while the resulting electromagnetic current itself is a
consequence of the QED anomaly. In the Sakai-Sugimoto model, which in a certain
limit is dual to large-N_c QCD, we discuss the proper implementation of the QED
axial anomaly, the (ambiguous) definition of chiral currents, and the
calculation of the chiral magnetic effect. We show that this model correctly
contains the so-called consistent anomaly, but requires the introduction of a
(holographic) finite counterterm to yield the correct covariant anomaly.
Introducing net chirality through an axial chemical potential, we find a
nonvanishing vector current only before including this counterterm. This seems
to imply the absence of the chiral magnetic effect in this model. On the other
hand, for a conventional quark chemical potential and large magnetic field,
which is of interest in the physics of compact stars, we obtain a nontrivial
result for the axial current that is in agreement with previous calculations
and known exact results for QCD.Comment: 35 pages, 4 figures, v2: added comments about frequency-dependent
conductivity at the end of section 4; references added; version to appear in
JHE
AP-1 imprints a reversible transcriptional program of senescent cells
Senescent cells affect many physiological and pathophysiological processes. While select genetic and epigenetic elements for senescence induction have been identified, the dynamics, epigenetic mechanisms and regulatory networks defining senescence competence, induction and maintenance remain poorly understood, precluding the deliberate therapeutic targeting of senescence for health benefits. Here, we examined the possibility that the epigenetic state of enhancers determines senescent cell fate. We explored this by generating time-resolved transcriptomes and epigenome profiles during oncogenic RAS-induced senescence and validating central findings in different cell biology and disease models of senescence. Through integrative analysis and functional validation, we reveal links between enhancer chromatin, transcription factor recruitment and senescence competence. We demonstrate that activator protein 1 (AP-1) âpioneersâ the senescence enhancer landscape and defines the organizational principles of the transcription factor network that drives the transcriptional programme of senescent cells. Together, our findings enabled us to manipulate the senescence phenotype with potential therapeutic implications
Study of the structure and kinematics of the NGC 7465/64/63 triplet galaxies
This paper is devoted to the analysis of new observational data for the group
of galaxies NGC 7465/64/63, which were obtained at the 6-m telescope of the
Special Astrophysical Observatory of the Russian Academy of Sciences (SAO RAS)
with the multimode instrument SCORPIO and the Multi Pupil Fiber Spectrograph.
For one of group members (NGC 7465) the presence of a polar ring was suspected.
Large-scale brightness distributions, velocity and velocity dispersion fields
of the ionized gas for all three galaxies as well as line-of-sight velocity
curves on the basis of emission and absorption lines and a stellar velocity
field in the central region for NGC 7465 were constructed. As a result of the
analysis of the obtained information, we revealed an inner stellar disk (r ~
0.5 kpc) and a warped gaseous disk in addition to the main stellar disk, in NGC
7465. On the basis of the joint study of photometric and spectral data it was
ascertained that NGC 7464 is the irregular galaxy of the IrrI type, whose
structural and kinematic peculiarities resulted most likely from the
gravitational interaction with NGC 7465. The velocity field of the ionized gas
of NGC 7463 turned out typical for spiral galaxies with a bar, and the bending
of outer parts of its disk could arise owing to the close encounter with one of
galaxies of the environment.Comment: 20 pages, 6 figure
Search for Fingerprints of Tetrahedral Symmetry in
Theoretical predictions suggest the presence of tetrahedral symmetry as an
explanation for the vanishing intra-band E2-transitions at the bottom of the
odd-spin negative parity band in . The present study reports on
experiment performed to address this phenomenon. It allowed to determine the
intra-band E2 transitions and branching ratios B(E2)/B(E1) of two of the
negative-parity bands in .Comment: presented by Q.T. Doan at XLII Zakopane School of Physics: Breaking
Frontiers: Submicron Structures in Physics and Biology, May 2008. 5 pages,
minor corrections. To be published in the proceeding
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