3,186 research outputs found
Riemannian tangent space mapping and elastic net regularization for cost-effective EEG markers of brain atrophy in Alzheimer's disease
The diagnosis of Alzheimer's disease (AD) in routine clinical practice is
most commonly based on subjective clinical interpretations. Quantitative
electroencephalography (QEEG) measures have been shown to reflect
neurodegenerative processes in AD and might qualify as affordable and thereby
widely available markers to facilitate the objectivization of AD assessment.
Here, we present a novel framework combining Riemannian tangent space mapping
and elastic net regression for the development of brain atrophy markers. While
most AD QEEG studies are based on small sample sizes and psychological test
scores as outcome measures, here we train and test our models using data of one
of the largest prospective EEG AD trials ever conducted, including MRI
biomarkers of brain atrophy.Comment: Presented at NIPS 2017 Workshop on Machine Learning for Healt
Monitoring grain boundary migration during recrystallisation using topotomography
International audienceThe growth of a single grain during recrystallisation into a mildly deformed {001}100 oriented single crystal has been monitored by synchrotron radiation using the topotomo technique. The formation and migration of individual facets is analysed using a new method which measures distances between grain boundary segments at different time steps along parallel lines normal to the facet plane. One facet is shown to move with a constant rate, while it remains planar and keeps the same boundary plane orientation. The formation of another facet, which is analysed in detail, reveals that first a planar boundary with a different orientation forms before it changes its boundary plane orientation into that of the final facet. It is argued that the local microstructural configuration in front of moving grain boundaries has a considerable influence on the kinetics of individual boundary segments and facets
Towards Probing Conformational States of Y2 Receptor Using Hyperpolarized 129Xe NMR
G protein-coupled receptors can adopt many different conformational states, each of them exhibiting different restraints towards downstream signaling pathways. One promising strategy to identify and quantify this conformational landscape is to introduce a cysteine at a receptor site sensitive to different states and label this cysteine with a probe for detection. Here, the application of NMR of hyperpolarized 129Xe for the detection of the conformational states of human neuropeptide Y2 receptor is introduced. The xenon trapping cage molecule cryptophane-A attached to a cysteine in extracellular loop 2 of the receptor facilitates chemical exchange saturation transfer experiments without and in the presence of native ligand neuropeptide Y. High-quality spectra indicative of structural states of the receptorâcage conjugate were obtained. Specifically, five signals could be assigned to the conjugate in the apo form. After the addition of NPY, one additional signal and subtle modifications in the persisting signals could be detected. The correlation of the spectroscopic signals and structural states was achieved with molecular dynamics simulations, suggesting frequent contact between the xenon trapping cage and the receptor surface but a preferred interaction with the bound ligand
Reliability Exercise for the Polymyalgia Rheumatica Classification Criteria Study: The Oranjewoud Ultrasound Substudy
Objective. A study supported by the EULAR and the ACR being conducted to establish classification criteria for polymyalgia rheumatica (PMR) will include ultrasound examination of the shoulders and hips. Ultrasound (US) depicts glenohumeral joint effusion, biceps tenosynovitis, subdeltoid bursitis, hip joint synovitis, and trochanteric bursitis in PMR. These findings may aid in distinguishing PMR from other diseases. The purpose of this study was to assess standards and US interreader agreement of participants in the PMR classification criteria study.
Methods. Sixteen physicians in four groups examined shoulders and hips of 4 patients and 4 healthy adults with ultrasound. Overall agreement and interobserver agreement were calculated. Results. The overall agreement (OA) between groups was 87%. The OA for healthy shoulders was 88.8%, for healthy hips 100%, for shoulders with pathology 85.2%, and 74.3% for hips with pathology, respectively. Conclusion. There was a high degree of agreement found for the examination of healthy shoulders and pathologic hips. Agreement was moderate for pathologic shoulders and perfect for healthy hips. US of shoulder and hips performed by different examiners is a reliable and feasible tool for assessment of PMR related disease pathology and can be incorporated into a classification criteria study
Dark-field X-ray microscopy for multiscale structural characterization
Many physical and mechanical properties of crystalline materials depend strongly on their internal structure, which is typically organized into grains and domains on several length scales. Here we present dark-field X-ray microscopy; a non-destructive microscopy technique for the three-dimensional mapping of orientations and stresses on lengths scales from 100ânm to 1âmm within embedded sampling volumes. The technique, which allows âzoomingâ in and out in both direct and angular space, is demonstrated by an annealing study of plastically deformed aluminium. Facilitating the direct study of the interactions between crystalline elements is a key step towards the formulation and validation of multiscale models that account for the entire heterogeneity of a material. Furthermore, dark-field X-ray microscopy is well suited to applied topics, where the structural evolution of internal nanoscale elements (for example, positioned at interfaces) is crucial to the performance and lifetime of macro-scale devices and components thereof
4D characterization of metals by 3DXRD
31st Riso International Symposium on Materials Science, Roskilde, DENMARK, SEP 06-10, 2010International audienceThe status of 3DXRD microscopy is reviewed, with a special view to applications in metallurgy. Various approaches are compared in terms of perfounance. In addition several recent advances are presented, such as a 3D grain map with an unprecedented spatial resolution of 500 nm, first results from the commissioning of a novel 3D detector set-up and a validation of the box-scan procedure
Optical Identification of the ASCA Large Sky Survey
We present results of optical identification of the X-ray sources detected in
the ASCA Large Sky Survey. Optical spectroscopic observations were done for 34
X-ray sources which were detected with the SIS in the 2-7 keV band above 3.5
sigma. The sources are identified with 30 AGNs, 2 clusters of galaxies, and 1
galactic star. Only 1 source is still unidentified. The flux limit of the
sample corresponds to 1 x 10^{-13} erg s^{-1} cm^{-2} in the 2-10 keV band.
Based on the sample, the paper discusses optical and X-ray spectral
properties of the AGNs, contribution of the sources to the Cosmic X-ray
Background, and redshift and luminosity distributions of the AGNs. An
interesting result is that the redshift distribution of the AGNs suggests a
deficiency of high-redshift (0.5 10^{44}
erg s^{-1}) absorbed narrow-line AGNs (so called type 2 QSOs).Comment: Accepted for publication in ApJ. 57 pages with 13 figures, 9 JPG
plates, 5 additional PS tables. Original EPS plates (gzipped format
~1Mbyte/plate) and TeX tables are available from
ftp://ftp.kusastro.kyoto-u.ac.jp/pub/akiyama/0001289
German Geographical Research on North America : A Bibliography with Comments and Annotations
The 27th International Geographical Congress in Washington, D.C., 1992 is the first geographical congress to take place in the United States for 40 years. This event and the 40th anniversaiy of the readmittance of Germany into the IGU offer a welconte opportunity of providing the international scientific Community with a survey of the research on North America by German and German speaking geographers in the form of a commentated bibliography
- âŠ