1,560 research outputs found
Individualized prognosis in childhood immune thrombocytopenia
Children with immune thrombocytopenia (ITP) show a primary hemostasis defect due to reduced number of platelets (thrombocytopenia). This leads to bleeding. In children, ITP is often transient and self-limiting (transient ITP), but some children show persistent thrombocytopenia or even chronic ITP. Treatment with immune-modulating medication like intravenous immunoglobulins (IVIg) leads to early recovery from thrombocytopenia and prevents bleeding. Unfortunately, treatment is only effective in a part of the patients. This dissertation aims to better understand, explain, and predict spontaneous recovery and favorable treatment outcomes after IVIg in a specific child with ITP. To that end, molecular disease mechanisms are being evaluated and analyzed together with clinical data. The dissertation provides novel data working towards individualized care for children with ITP. This is relevant for communication with the child and caregivers over the expected prognosis, treatment decisions (IVIg), and indications for early additional diagnostic testing for other causes of thrombocytopenia (such as genetic tests). Landsteiner Foundation for Blood Transfusion Research (LSBR); Studienstiftung des Deutschen Volkes.LUMC / Geneeskund
Resonantly enhanced nonlinear optics in semiconductor quantum wells: An application to sensitive infrared detection
A novel class of coherent nonlinear optical phenomena, involving induced
transparency in quantum wells, is considered in the context of a particular
application to sensitive long-wavelength infrared detection. It is shown that
the strongest decoherence mechanisms can be suppressed or mitigated, resulting
in substantial enhancement of nonlinear optical effects in semiconductor
quantum wells.Comment: 4 pages, 3 figures, replaced with revised versio
Creation and Growth of Components in a Random Hypergraph Process
Denote by an -component a connected -uniform hypergraph with
edges and vertices. We prove that the expected number of
creations of -component during a random hypergraph process tends to 1 as
and tend to with the total number of vertices such that
. Under the same conditions, we also show that
the expected number of vertices that ever belong to an -component is
approximately . As an immediate
consequence, it follows that with high probability the largest -component
during the process is of size . Our results
give insight about the size of giant components inside the phase transition of
random hypergraphs.Comment: R\'{e}sum\'{e} \'{e}tend
CD8 T cell function and cross-reactivity explored by stepwise increased peptide-HLA versus TCR affinity.
Recruitment and activation of CD8 T cells occur through specific triggering of T cell receptor (TCR) by peptide-bound human leucocyte antigen (HLA) ligands. Within the generated trimeric TCR-peptide:HLA complex, the molecular binding affinities between peptide and HLA, and between TCR and peptide:HLA both impact T cell functional outcomes. However, how their individual and combined effects modulate immunogenicity and overall T cell responsiveness has not been investigated systematically. Here, we established two panels of human tumor peptide variants differing in their affinity to HLA. For precise characterization, we developed the "blue peptide assay", an upgraded cell-based approach to measure the peptide:HLA affinity. These peptide variants were then used to investigate the cross-reactivity of tumor antigen-specific CD8 T cell clonotypes derived from blood of cancer patients after vaccination with either the native or an affinity-optimized Melan-A/MART-1 epitope, or isolated from tumor infiltrated lymph nodes (TILNs). Vaccines containing the native tumor epitope generated T cells with better functionality, and superior cross-reactivity against potential low affinity escape epitopes, as compared to T cells induced by vaccines containing an HLA affinity-optimized epitope. Comparatively, Melan-A/MART-1-specific TILN cells displayed functional and cross-reactive profiles that were heterogeneous and clonotype-dependent. Finally, we took advantage of a collection of T cells expressing affinity-optimized NY-ESO-1-specific TCRs to interrogate the individual and combined impact of peptide:HLA and TCR-pHLA affinities on overall CD8 T cell responses. We found profound and distinct effects of both biophysical parameters, with additive contributions and absence of hierarchical dominance. Altogether, the biological impact of peptide:HLA and TCR-pHLA affinities on T cell responses was carefully dissected in two antigenic systems, frequently targeted in human cancer immunotherapy. Our technology and stepwise comparison open new insights into the rational design and selection of vaccine-associated tumor-specific epitopes and highlight the functional and cross-reactivity profiles that endow T cells with best tumor control capacity
Superconducting anisotropy and evidence for intrinsic pinning in single crystalline MgB
We examine the superconducting anisotropy
of a metallic high- superconductor MgB by measuring the magnetic
torque of a single crystal. The anisotropy does not depend
sensitively on the applied magnetic field at 10 K. We obtain the anisotropy
parameter . The torque curve shows the sharp
hysteresis peak when the field is applied parallel to the boron layers. This
comes from the intrinsic pinning and is experimental evidence for the
occurrence of superconductivity in the boron layers.Comment: REVTeX 4, To be published in Physical Review
Casimir Effect on the Worldline
We develop a method to compute the Casimir effect for arbitrary geometries.
The method is based on the string-inspired worldline approach to quantum field
theory and its numerical realization with Monte-Carlo techniques. Concentrating
on Casimir forces between rigid bodies induced by a fluctuating scalar field,
we test our method with the parallel-plate configuration. For the
experimentally relevant sphere-plate configuration, we study curvature effects
quantitatively and perform a comparison with the ``proximity force
approximation'', which is the standard approximation technique. Sizable
curvature effects are found for a distance-to-curvature-radius ratio of a/R >~
0.02. Our method is embedded in renormalizable quantum field theory with a
controlled treatment of the UV divergencies. As a technical by-product, we
develop various efficient algorithms for generating closed-loop ensembles with
Gaussian distribution.Comment: 27 pages, 10 figures, Sect. 2.1 more self-contained, improved data
for Fig. 6, minor corrections, new Refs, version to be published in JHE
Guiding center picture of magnetoresistance oscillations in rectangular superlattices
We calculate the magneto-resistivities of a two-dimensional electron gas
subjected to a lateral superlattice (LSL) of rectangular symmetry within the
guiding-center picture, which approximates the classical electron motion as a
rapid cyclotron motion around a slowly drifting guiding center. We explicitly
evaluate the velocity auto-correlation function along the trajectories of the
guiding centers, which are equipotentials of a magnetic-field dependent
effective LSL potential. The existence of closed equipotentials may lead to a
suppression of the commensurability oscillations, if the mean free path and the
LSL modulation potential are large enough. We present numerical and analytical
results for this suppression, which allow, in contrast to previous quantum
arguments, a classical explanation of similar suppression effects observed
experimentally on square-symmetric LSL. Furthermore, for rectangular LSLs of
lower symmetry they lead us to predict a strongly anisotropic resistance
tensor, with high- and low-resistance directions which can be interchanged by
tuning the externally applied magnetic field.Comment: 12 pages, 9 figure
Axial vector form factor of nucleons in a light-cone diquark model
The nucleon axial vector form factor is investigated in a light-cone quark
spectator diquark model, in which Melosh rotations are applied to both the
quark and vector diquark. It is found that this model gives a very good
description of available experimental data and the results have very little
dependence on the parameters of the model. The relation between the nucleon
axial constant and the anomalous magnetic moment of nucleons is also discussed.Comment: 8 pages, Revtex4, 1 figure, version to be published in Phys. Rev.
Single-photon Transistors Based on the Interaction of an Emitter and Surface Plasmons
A symmetrical approach is suggested (Chang DE et al. Nat Phys 3:807, 2007) to realize a single-photon transistor, where the presence (or absence) of a single incident photon in a ‘gate’ field is sufficient to allow (prevent) the propagation of a subsequent ‘signal’ photon along the nanowire, on condition that the ‘gate’ field is symmetrically incident from both sides of an emitter simultaneously. We present a scheme for single-photon transistors based on the strong emitter-surface-plasmon interaction. In this scheme, coherent absorption of an incoming ‘gate’ photon incident along a nanotip by an emitter located near the tip of the nanotip results in a state flip in the emitter, which controls the subsequent propagation of a ‘signal’ photon in a nanowire perpendicular to the axis of the nanotip
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