"Das schnelle Date". Internetgestützte Sexkontakte und HIV-Infektionsrisiko. Ergebnisse einer 2006 durchgeführten Internetbefragung

Der seit Ende der 1990er Jahre diskutierten Frage, ob bei Sexualkontakten, die über Kontaktseiten im Internet hergestellt werden, in geringerem Umfang präventive Vorkehrungen in Hinblick auf HIV-Übertragungen erfolgen als bei andernorts angebahnten Kontakten, sollte in einer im Frühjahr 2006 durchgeführten Online-Umfrage nachgegangen werden. Die Umfrage erfolgte über vier Dating-Portale für heterosexuelle Frauen und Männer und über vier Portale für homound bisexuelle Männer. Von den berücksichtigten 5.050 Fragebögen entfielen 76 Prozent auf Männer, die ausschließlich gleichgeschlechtliche Sexualkontakte in den 12 Monaten vor der Befragung angaben, 11 Prozent der Männer wurden aufgrund ihrer Angaben als bisexuell und weitere 11 Prozent als heterosexuell definiert. Frauen stellten lediglich 2 Prozent der BefragungsteilnehmerInnen. Etwa drei Viertel aller Befragten schätzten an Kontaktseiten, das sie darüber Menschen „mit gleichen Vorlieben“ kennenlernen können, dabei muss es sich nicht um sexuelle Vorlieben handeln: So haben etwa 22 Prozent der Frauen, 12 Prozent der homosexuellen, 9 Prozent der heterosexuellen und 6 Prozent der bisexuellen Männer überhaupt keine(n) Sexpartner(in) in den 12 Monaten vor der Befragung gesucht. Online gesucht aber keine(n) Partner(in) gefunden haben 18 Prozent der Frauen, 21 Prozent der homosexuellen, 24 Prozent der bisexuellen und 45 Prozent der heterosexuellen Männer. Etwa die Hälfte der homo- und bisexuellen Männer haben ihre SexualpartnerInnen mehrheitlich oder ausschließlich über das Internet kennengelernt, während dies nur auf 39 Prozent der heterosexuellen Männer zutrifft (zwei Drittel geben dies in der kleinen Gruppe der Frauen an). Dass heterosexuelle Männer die geringsten Erfolge beim Anbahnen von Sexualkontakten über das Internet haben, zeigen auch andere erhobene Daten. Unter den Befragungsteilnehmern erfolgte regelmäßiger Kondomgebrauch bei Vaginal- oder Analverkehr – je nach Gruppenzugehörigkeit - zu sehr unterschiedlichen Anteilen. 55 Prozent der homosexuellen und 47 Prozent der bisexuellen Männer benutzten grundsätzlich Kondome, 38 Prozent der heterosexuellen Männer und 34 Prozent der Frauen gaben dies an. Hinsichtlich des Risikos, sich mit HIV zu infizieren (ungeschützter Anal- oder Vaginalverkehr mit PartnerInnen mit unbekanntem oder diskordantem Serostatus - Expositionsrisiko), bestanden nur geringe Unterschiede zwischen homo- (27%), bi- (31%) und heterosexuellen Männern (26%) bzw. Frauen (27%). Ein Transmissionsrisiko konnte lediglich in der Teilgruppe der homosexuellen (8%) und bisexuellen (1%) Männer festgestellt werden, da in den anderen beiden Gruppen niemand HIV-positiv war. Es zeigt sich, dass bei der überwiegenden Mehrheit aller Befragten das HIV-bezogene sexuelle Risikoverhalten bei online- und offline-Dates gleich ist. Are people more likely to risk an HIV infection with sex partners they meet online as compared to those whom they meet offline? This question has been the subject of research since the late 1990s in several post-industrialized countries. This paper presents the results of a study conducted in Germany in 2006. A link to an anonymous, self-administered online questionnaire was posted on four dating websites for heterosexual men and women and on four dating websites for men who have sex with men. Of the 5,050 respondents included in the analysis, 76 per cent were men who reported sexual contacts in the previous twelve months exclusively with other men; 11 per cent could be classified as bisexual men (sexual contacts with men and women), and 11 per cent as heterosexual men (sexual contact with women only).. Two per cent of all respondents were women; because of the small number of respondents this group was not further stratified in the analysis. Finding persons “with similar interests” was the most frequently expressed positive aspect of dating websites (78% among homosexual men, 80% among bisexual men, 74% among heterosexual men, and 73% among women). This did not necessarily mean similar sexual interests: 22 per cent of the women, 12 per cent of the homosexual men, 6 per cent of the bisexual men, and 9 per cent of the heterosexual men claimed they had not been looking for sex partners during their visits to the sites in the previous twelve months. Many respondents reported being unsuccessful in finding a sex partner online: 18 per cent of the women, 21 per cent of the homosexual men, 24 per cent of the bisexual men, and 45 per cent of the heterosexual men. While during the previous twelve months half of the homo- and bisexual men found most (if not all) of their sex partners on the Internet, the respective proportions were 39 per cent among heterosexual men, and 67% in the small group of female respondents. Taken together, heterosexual men were the least successful in finding sex partners on the Internet. Regular use of condoms for every anal or vaginal intercourse was reported by 55 per cent of the homosexual men, 47 per cent of the bisexual men, 38 of the heterosexual men, and 34 per cent of the women. However, regarding unprotected anal or vaginal intercourse with a sex partner of unknown or discordant HIV serostatus, the proportions among the different subgroups were very similar (homosexual men: 27%; bisexual men: 31%; heterosexual men: 26%; women: 27%). The risk of transmitting a known HIV infection to sex partners was only present among homosexual (8%) and bisexual (1%) men, primarily because only respondents from these two subgroups identified as HIV-positive. For the large majority (83-86%) of men, HIV risk behaviours are the same, regardless if sex partners are met online or offline

Atopic dermatitis and risk of atrial fibrillation or flutter: A 35-year follow-up study.

BACKGROUND: Atopic dermatitis is characterized by chronic inflammation, which is a risk factor for atrial fibrillation. OBJECTIVE: To examine the association between hospital-diagnosed atopic dermatitis and atrial fibrillation. METHODS: Using linked population-based Danish registries, we identified persons with an inpatient or outpatient hospital diagnosis of atopic dermatitis during 1977-2013 and a comparison cohort individually matched to the atopic dermatitis cohort. We followed cohorts until death, emigration, atrial fibrillation diagnosis, or end of study (January 1, 2013). We compared 35-year risk of atrial fibrillation and estimated hazard ratios with 95% confidence intervals using Cox regression, adjusting for birth year and sex. We validated 100 atopic dermatitis diagnoses from a dermatologic department through medical record review. RESULTS: We included 13,126 persons with atopic dermatitis and 124,211 comparators and followed them for a median of 19.3 years. The 35-year risk of atrial fibrillation was 0.81% and 0.67%, respectively. The positive predictive value of atopic dermatitis diagnoses was 99%. The hazard ratio was 1.2 (95% confidence interval 1.0-1.6) and remained increased after adjusting for various atrial fibrillation risk factors. LIMITATIONS: Analyses were limited to persons with moderate-to-severe atopic dermatitis, and we had no lifestyle data. CONCLUSION: Patients with hospital-diagnosed atopic dermatitis have a 20% increased long-term risk of atrial fibrillation, but the absolute risk remains low

The association between muscular power from childhood to adulthood and adult measures of glucose homeostasis

This study aimed to assess whether the longitudinal association between childhood muscular fitness and adult measures of glucose homeostasis persist despite changes in muscular fitness across the life course. This prospective longitudinal study included 586 participants who had their muscular power (standing long jump distance), cardiorespiratory fitness (CRF), and waist circumference measured as children (aged 9, 12, 15 years) and again 20 years later as adults. In adulthood, these participants also provided a fasting blood sample which was tested for glucose and insulin. Glucose homeostasis measures including insulin resistance (HOMA2-IR) and beta cell function (HOMA2-β) were estimated. Child and adult muscular power levels were separated into thirds, and tracking groups (persistently low, decreasing, persistently moderate, increasing, and persistently high) were created. Sex-stratified multivariable linear regression models were used to examine the association between muscular power tracking groups and adult measures of glucose homeostasis. Compared with males with persistently high muscular power, males with increasing and persistently low muscular power had higher fasting insulin (increasing: β = 1.12 mU/L, P = .04; persistently low: β = 2.12 mU/L, P = .001) and HOMA2-β (increasing: β = 8.50%, P = .03; persistently low: β = 11.27%, P = .01) independent of CRF and males with persistently low muscular power had greater fasting insulin (β = 1.22 mU/L, P = .02) and HOMA2-IR (β = 0.14, P = .02) independent of waist circumference. Non-significant associations were present for females. For males, maintaining persistently high muscular power between childhood and adulthood could lead to a healthier adult glucose homeostasis profile

Audition in vampire bats, Desmodus rotundus

1. Within the tonotopic organization of the inferior colliculus two frequency ranges are well represented: a frequency range within that of the echolocation signals from 50 to 100 kHz, and a frequency band below that of the echolocation sounds, from 10 to 35 kHz. The frequency range between these two bands, from about 40 to 50 kHz is distinctly underrepresented (Fig. 3B). 2. Units with BFs in the lower frequency range (10–25 kHz) were most sensitive with thresholds of -5 to -11 dB SPL, and units with BFs within the frequency range of the echolocation signals had minimal thresholds around 0 dB SPL (Fig. 1). 3. In the medial part of the rostral inferior colliculus units were encountered which preferentially or exclusively responded to noise stimuli. — Seven neurons were found which were only excited by human breathing noises and not by pure tones, frequency modulated signals or various noise bands. These neurons were considered as a subspeciality of the larger sample of noise-sensitive neurons. — The maximal auditory sensitivity in the frequency range below that of echolocation, and the conspicuous existence of noise and breathing-noise sensitive units in the inferior colliculus are discussed in context with the foraging behavior of vampire bats

Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study.

OBJECTIVE: To investigate whether adults with atopic eczema are at an increased risk of cardiovascular disease and whether the risk varies by atopic eczema severity and condition activity over time. DESIGN: Population based matched cohort study. SETTING: UK electronic health records from the Clinical Practice Research Datalink, Hospital Episode Statistics, and data from the Office for National Statistics, 1998-2015. PARTICIPANTS: Adults with a diagnosis of atopic eczema, matched (on age, sex, general practice, and calendar time) to up to five patients without atopic eczema. MAIN OUTCOME MEASURES: Cardiovascular outcomes (myocardial infarction, unstable angina, heart failure, atrial fibrillation, stroke, and cardiovascular death). RESULTS: 387 439 patients with atopic eczema were matched to 1 528 477 patients without atopic eczema. The median age was 43 at cohort entry and 66% were female. Median follow-up was 5.1 years. Evidence of a 10% to 20% increased hazard for the non-fatal primary outcomes for patients with atopic eczema was found by using Cox regression stratified by matched set. There was a strong dose-response relation with severity of atopic eczema. Patients with severe atopic eczema had a 20% increase in the risk of stroke (hazard ratio 1.22, 99% confidence interval 1.01 to 1.48), 40% to 50% increase in the risk of myocardial infarction, unstable angina, atrial fibrillation, and cardiovascular death, and 70% increase in the risk of heart failure (hazard ratio 1.69, 99% confidence interval 1.38 to 2.06). Patients with the most active atopic eczema (active >50% of follow-up) were also at a greater risk of cardiovascular outcomes. Additional adjustment for cardiovascular risk factors as potential mediators partially attenuated the point estimates, though associations persisted for severe atopic eczema. CONCLUSIONS: Severe and predominantly active atopic eczema are associated with an increased risk of cardiovascular outcomes. Targeting cardiovascular disease prevention strategies among these patients should be considered

The Geography of Sexual Orientation: Structural Stigma and Sexual Attraction, Behavior, and Identity Among Men Who Have Sex with Men Across 38 European Countries.

: While the prevalence of sexual identities and behaviors of men who have sex with men (MSM) varies across countries, no study has examined country-level structural stigma toward sexual minorities as a correlate of this variation. Drawing on emerging support for the context-dependent nature of MSM's open sexual self-identification cross-nationally, we examined country-level structural stigma as a key correlate of the geographic variation in MSM's sexual attraction, behavior, and identity, and concordance across these factors. Data come from the European MSM Internet Survey, a multi-national dataset containing a multi-component assessment of sexual orientation administered across 38 European countries (N = 174,209). Country-level stigma was assessed using a combination of national laws and policies affecting sexual minorities and a measure of attitudes toward sexual minorities held by the citizens of each country. Results demonstrate that in more stigmatizing countries, MSM were significantly more likely to report bisexual/heterosexual attractions, behaviors, and identities, and significantly less likely to report concordance across these factors, than in less stigmatizing countries. Settlement size moderated associations between country-level structural stigma and odds of bisexual/heterosexual attraction and behavior, such that MSM living in sparsely populated locales within high-structural stigma countries were the most likely to report bisexual or heterosexual behaviors and attractions. While previous research has demonstrated associations between structural stigma and adverse physical and mental health outcomes among sexual minorities, this study was the first to show that structural stigma was also a key correlate not only of sexual orientation identification, but also of MSM's sexual behavior and even attraction. Findings have implications for understanding the ontology of MSM's sexuality and suggest that a comprehensive picture of MSM's sexuality will come from attending to the local contexts surrounding this important segment of the global population.<br/

Brain-computer interfacing using modulations of alpha activity induced by covert shifts of attention

Contains fulltext : 99949.pdf (publisher's version ) (Open Access)Background: Visual brain-computer interfaces (BCIs) often yield high performance only when targets are fixated with the eyes. Furthermore, many paradigms use intense visual stimulation, which can be irritating especially in long BCI sessions. However, BCIs can more directly directly tap the neural processes underlying visual attention. Covert shifts of visual attention induce changes in oscillatory alpha activity in posterior cortex, even in the absence of visual stimulation. The aim was to investigate whether different pairs of directions of attention shifts can be reliably differentiated based on the electroencephalogram. To this end, healthy participants (N = 8) had to strictly fixate a central dot and covertly shift visual attention to one out of six cued directions. Results: Covert attention shifts induced a prolonged alpha synchronization over posterior electrode sites (PO and O electrodes). Spectral changes had specific topographies so that different pairs of directions could be differentiated. There was substantial variation across participants with respect to the direction pairs that could be reliably classified. Mean accuracy for the best-classifiable pair amounted to 74.6%. Furthermore, an alpha power index obtained during a relaxation measurement showed to be predictive of peak BCI performance (r = .66). Conclusions: Results confirm posterior alpha power modulations as a viable input modality for gaze-independent EEG-based BCIs. The pair of directions yielding optimal performance varies across participants. Consequently, participants with low control for standard directions such as left-right might resort to other pairs of directions including top and bottom. Additionally, a simple alpha index was shown to predict prospective BCI performance.10 p

Risk Factors for Scrub Typhus, Murine Typhus, and Spotted Fever Seropositivity in Urban Areas, Rural Plains, and Peri-Forest Hill Villages in South India: A Cross-Sectional Study.

Scrub typhus and spotted fever group rickettsioses are thought to be common causes of febrile illness in India, whereas they rarely test for murine typhus. This cross-sectional study explored the risk factors associated with scrub typhus, tick-borne spotted fever, and murine typhus seropositivity in three different geographical settings, urban, rural, and hill villages in Tamil Nadu, South India. We enrolled 1,353 participants living in 48 clusters. The study included a questionnaire survey and blood sampling. Blood was tested for Orientia tsutsugamushi (scrub typhus), Rickettsia typhi (murine typhus), and spotted fever group Rickettsia IgG using ELISA. The seroprevalence of scrub typhus, spotted fever, and murine typhus were 20.4%, 10.4%, and 5.4%, respectively. Scrub typhus had the highest prevalence in rural areas (28.1%), and spotted fever was most common in peri-forested areas (14.9%). Murine typhus was more common in rural (8.7%) than urban areas (5.4%) and absent in peri-forested hill areas. Agricultural workers had a higher relative risk for scrub typhus, especially in urban areas. For murine typhus, proximity to a waterbody and owning a dog were found to be major risk factors. The main risk factors for spotted fever were agricultural work and living in proximity to a forest. Urban, rural plains, and hill settings display distinct epidemiological pattern of Orientia and rickettsial infections. Although scrub typhus and spotted fever were associated with known risk factors in this study, the findings suggest a different ecology of murine typhus transmission compared with other studies conducted in Asia

The association between grip strength measured in childhood, young- and mid-adulthood and prediabetes or type 2 diabetes in mid-adulthood

Background: Although low child and adult grip strength is associated with adverse cardiometabolic health, how grip strength across the life course associates with type 2 diabetes is unknown. This study identified the relative contribution of grip strength measured at specific life stages (childhood, young adulthood, mid-adulthood) with prediabetes or type 2 diabetes in mid-adulthood. Methods: Between 1985 and 2019, 263 participants had their grip strength measured using an isometric dynamometer in childhood (9-15 years), young adulthood (28-36 years) and mid-adulthood (38-49 years). In mid-adulthood, a fasting blood sample was collected and tested for glucose and glycated haemoglobin (HbA1c). Participants were categorized as having prediabetes or type 2 diabetes if fasting glucose levels were ≥ 5.6 mmol or if HbA1c levels were ≥ 5.7% (≥ 39 mmol/mol). A Bayesian relevant life course exposure model examined the association between lifelong grip strength and prediabetes or type 2 diabetes. Results: Grip strength at each time point was equally associated with prediabetes or type 2 diabetes in mid-adulthood (childhood: 37%, young adulthood: 36%, mid-adulthood: 28%). A one standard deviation increase in cumulative grip strength was associated with 34% reduced odds of prediabetes or type 2 diabetes in mid-adulthood (OR 0.66, 95% credible interval 0.40, 0.98). Conclusions: Greater grip strength across the life course could protect against the development of prediabetes and type 2 diabetes. Strategies aimed at increasing muscular strength in childhood and maintaining behaviours to improve strength into adulthood could improve future cardiometabolic health. The Association Between Grip Strength Measured in Childhood, Young- and Mid-adulthood and Prediabetes or Type 2 Diabetes in Mid-adulthood