79 research outputs found
Phase structures of strong coupling lattice QCD with finite baryon and isospin density
Quantum chromodynamics (QCD) at finite temperature (T), baryon chemical
potential (\muB) and isospin chemical potential (\muI) is studied in the strong
coupling limit on a lattice with staggered fermions. With the use of large
dimensional expansion and the mean field approximation, we derive an effective
action written in terms of the chiral condensate and pion condensate as a
function of T, \muB and \muI. The phase structure in the space of T and \muB is
elucidated, and simple analytical formulas for the critical line of the chiral
phase transition and the tricritical point are derived. The effects of a finite
quark mass (m) and finite \muI on the phase diagram are discussed. We also
investigate the phase structure in the space of T, \muI and m, and clarify the
correspondence between color SU(3) QCD with finite isospin density and color
SU(2) QCD with finite baryon density. Comparisons of our results with those
from recent Monte Carlo lattice simulations on finite density QCD are given.Comment: 18 pages, 6 figures, revtex4; some discussions are clarified, version
to appear in Phys. Rev.
Development and external validation study of a melanoma risk prediction model incorporating clinically assessed naevi and solar lentigines
Background:
Melanoma risk prediction models could be useful for matching preventive interventions to patients’ risk.
Objectives:
To develop and validate a model for incident first‐primary cutaneous melanoma using clinically assessed risk factors.
Methods:
We used unconditional logistic regression with backward selection from the Australian Melanoma Family Study (461 cases and 329 controls) in which age, sex and city of recruitment were kept in each step, and we externally validated it using the Leeds Melanoma Case–Control Study (960 cases and 513 controls). Candidate predictors included clinically assessed whole‐body naevi and solar lentigines, and self‐assessed pigmentation phenotype, sun exposure, family history and history of keratinocyte cancer. We evaluated the predictive strength and discrimination of the model risk factors using odds per age‐ and sex‐adjusted SD (OPERA) and the area under curve (AUC), and calibration using the Hosmer–Lemeshow test.
Results:
The final model included the number of naevi ≥ 2 mm in diameter on the whole body, solar lentigines on the upper back (a six‐level scale), hair colour at age 18 years and personal history of keratinocyte cancer. Naevi was the strongest risk factor; the OPERA was 3·51 [95% confidence interval (CI) 2·71–4·54] in the Australian study and 2·56 (95% CI 2·23–2·95) in the Leeds study. The AUC was 0·79 (95% CI 0·76–0·83) in the Australian study and 0·73 (95% CI 0·70–0·75) in the Leeds study. The Hosmer–Lemeshow test P‐value was 0·30 in the Australian study and < 0·001 in the Leeds study.
Conclusions:
This model had good discrimination and could be used by clinicians to stratify patients by melanoma risk for the targeting of preventive interventions.
What's already known about this topic?
Melanoma risk prediction models may be useful in prevention by tailoring interventions to personalized risk levels.
For reasons of feasibility, time and cost many melanoma prediction models use self‐assessed risk factors. However, individuals tend to underestimate their naevus numbers.
What does this study add?
We present a melanoma risk prediction model, which includes clinically‐assessed whole‐body naevi and solar lentigines, and self‐assessed risk factors including pigmentation phenotype and history of keratinocyte cancer.
This model performs well on discrimination, the model's ability to distinguish between individuals with and without melanoma, and may assist clinicians to stratify patients by melanoma risk for targeted preventive interventions
Rapid and highly variable warming of lake surface waters around the globe
Peer reviewed. ©2015. The Authors.This is an open access article under theterms of the Creative CommonsAttribution-NonCommercial-N oDerivsLicense, which permits use and distri-bution in any medium, provided theoriginal work is properly cited, the use isnon-commerc ial and no modificationsor adaptations are made.In this first worldwide synthesis of in situ and satellite-derived lake data, we find that lake summer surface water temperatures rose rapidly (global mean = 0.34°C decade 1) between 1985 and 2009. Our analyses show that surface water warming rates are dependent on combinations of climate and
local characteristics, rather than just lake location, leading to the counterintuitive result that regional consistency in lake warming is the exception, rather than the rule. The most rapidly warming lakes are widely geographically distributed, and their warming is associated with interactions among different climatic factors —from seasonally ice-covered lakes in areas where temperature and solar radiation are increasing while cloud cover is diminishing (0.72°C decade 1) to ice-free lakes experiencing increases in air temperature
and solar radiation (0.53°C decade 1). The pervasive and rapid warming observed here signals the urgent need to incorporate climate impacts into vulnerability assessments and adaptation efforts for lakes
Design parameters and operating characteristics of animal waste anaerobic digestion systems. Beef cattle
Analysis of the Time Relationship for the Interaction of X-ray-induced Primary Breaks in the Formation of Dicentric Chromosomes
Zoster sine herpete: Virologic verification by detection of anti-VZV IgG antibody in CSF
Bisphosphonate-Induced Osteonecrosis of the Jaw: Comparison of Disease Extent on Contrast-Enhanced MR Imaging, [ 18
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