On the Benefit of Virtualization: Strategies for Flexible Server Allocation

Virtualization technology facilitates a dynamic, demand-driven allocation and migration of servers. This paper studies how the flexibility offered by network virtualization can be used to improve Quality-of-Service parameters such as latency, while taking into account allocation costs. A generic use case is considered where both the overall demand issued for a certain service (for example, an SAP application in the cloud, or a gaming application) as well as the origins of the requests change over time (e.g., due to time zone effects or due to user mobility), and we present online and optimal offline strategies to compute the number and location of the servers implementing this service. These algorithms also allow us to study the fundamental benefits of dynamic resource allocation compared to static systems. Our simulation results confirm our expectations that the gain of flexible server allocation is particularly high in scenarios with moderate dynamics

Consistent SDNs through Network State Fuzzing

The conventional wisdom is that a software-defined network (SDN) operates under the premise that the logically centralized control plane has an accurate representation of the actual data plane state. Unfortunately, bugs, misconfigurations, faults or attacks can introduce inconsistencies that undermine correct operation. Previous work in this area, however, lacks a holistic methodology to tackle this problem and thus, addresses only certain parts of the problem. Yet, the consistency of the overall system is only as good as its least consistent part. Motivated by an analogy of network consistency checking with program testing, we propose to add active probe-based network state fuzzing to our consistency check repertoire. Hereby, our system, PAZZ, combines production traffic with active probes to periodically test if the actual forwarding path and decision elements (on the data plane) correspond to the expected ones (on the control plane). Our insight is that active traffic covers the inconsistency cases beyond the ones identified by passive traffic. PAZZ prototype was built and evaluated on topologies of varying scale and complexity. Our results show that PAZZ requires minimal network resources to detect persistent data plane faults through fuzzing and localize them quickly while outperforming baseline approaches.Comment: Added three extra relevant references, the arXiv later was accepted in IEEE Transactions of Network and Service Management (TNSM), 2019 with the title "Towards Consistent SDNs: A Case for Network State Fuzzing

Position and Mode Dependent Optical Detection Back-Action in Cantilever Beam Resonators

Optical detection back-action in cantilever resonant or static detection presents a challenge when striving for state-of-the-art performance. The origin and possible routes for minimizing optical back-action have received little attention in literature. Here, we investigate the position and mode dependent optical back-action on cantilever beam resonators. A high power heating laser (100 {\mu}W) is scanned across a silicon nitride cantilever while its effect on the first three resonance modes is detected via a low-power readout laser (1 {\mu}W) positioned at the cantilever tip. We find that the measured effect of back-action is not only dependent on position but also the shape of the resonance mode. Relevant silicon nitride material parameters are extracted by fitting the temperature-dependent frequency response of the first three modes to finite element (FE) simulations. In a second round of simulations, using the extracted parameters, we successfully fit the FEM results with the measured mode and position dependent back-action. Finally, different routes for minimizing the effect of this optical detection back-action are described, allowing further improvements of cantilever-based sensing in general

Characteristics of “Tip-DCs and MDSCs” and Their Potential Role in Leishmaniasis

Since the first description of dendritic cells (DCs) by Steinman and Cohn (1973), the myeloid lineage of leukocytes was investigated intensively. Nowadays it is obvious that myeloid cells, especially DCs, are crucial for the adaptive and innate immune response against intracellular pathogens such as Leishmania major parasites. Based on the overlapping expression of molecules that were commonly used to classify myeloid cells, it becomes difficult to denominate those cell types precisely. Of note, most of these markers used for myeloid cell identification are expressed on a broad range of myeloid cells, and should therefore be handled with care if used for subtyping of myeloid cells. In this mini-review we aim to discuss the relative impact of DCs that release TNF and nitric oxide (Tip-DCs) and myeloid cells with suppressive capacities (myeloid-derived suppressor cells, MDSCs) in infectious diseases such as experimental leishmaniasis. In our point of view it cannot be excluded that the novel subsets that were denominated as “Tip-DCs” and “MDSCs” might not be classical “subsets” but rather represent myeloid cells in a transient maturation stage expressing different genes, in response to the surrounding environment

Investigating the use of digital health tools in physiotherapy: facilitators and barriers

Background: Digital tools are becoming more and more common in healthcare. Their potential to improve treatment, monitoring, and coaching in physiotherapy has been recognized. Yet studies report that the adoption of digital health tools in ambulatory physiotherapy is rather low and that their potential is underexploited. Objective: This paper aims to investigate how digital health tools in general, and the mobile health tool physitrackTM (hereafter the app) more particularly, are used in outpatient physiotherapy clinics and also to identify what facilitates or hinders the app’s use. Methods: The paper is part of a larger study and adopts an ethnographic approach. It is based on observational and interview data collected at two outpatient clinics. Results: We reveal how physiotherapists and patients use the app in physiotherapy and identify 16 interdependent factors, on the macro-, meso-, and micro-level, that either facilitate or hinder its use. Conclusions: We argue that a single factor’s facilitating or hindering impact cannot be grasped in isolation but needs to be investigated as one piece of a dynamic interplay. Further qualitative research is required, especially to shed more light on the app’s compatibility with physiotherapy practice and use in therapist-patient interactions

Panopticon: Reaping the Benefits of Partial SDN Deployment in Enterprise Networks

The operational challenges posed in enterprise networks, present an appealing opportunity for the software-defined orchestration of the network (SDN). However, the primary challenge to realizing solutions built on SDN in the enterprise is the deployment problem. Unlike in the data-center, network upgrades in the enterprise start with the existing deployment and are budget and resource-constrained. In this work, we investigate the prospect for partial Software Defined Network (SDN) deployment. We present Panopticon, an architecture and methodology for planning and operating networks that combine legacy and upgraded SDN switches. Panopticon exposes an abstraction of a logical SDN in a partially upgraded legacy network, where the SDN benefits extend potentially over the entire network. We evaluate the feasibility of our approach through simulation on real enterprise campus network topologies entailing over 1500 switches and routers. Our results suggest that with only a handful of upgraded switches, it becomes possible to operate most of an enterprise network as a single SDN while meeting key resource constraints

Adoptive Immunotherapy in Chimeras with Donor Lymphocytes

Allogeneic stem cell transplantation has a well-defined indication in the treatment of hematological malignancies. The beneficial immune effect of allogeneic marrow transplantation has long been known, but only recently have methods been developed to separate the graft-versus-leukemia (GVL) effect from graft-versus-host disease (GVHD). Animal experiments have shown that lymphocytes from the marrow donor can be transfused without causing severe GVHD if stable chimerism and tolerance is established. First clinical studies have been preformed in patients with recurrent chronic myelogenous leukemia. In these patients complete molecular remissions were induced that persist without further maintenance treatment. These results have been confirmed in larger multicenter studies in Europe and the USA. The best results were obtained in chronic myelogenous leukemia (CML); repeated successes have been reported in relapsing acute myeloid leukemia (AML), myelodysplastic syndromes and multiple myeloma (MMY), and rare responses were reported for acute lymphoid leukemia. Contrary to animal experiments GVHD has been observed in human patients although to a lesser extent than expected in transplants not given immunosuppression. Secondly myelosuppression has been observed in patients treated with relapsing CML. In CML the incidence of GVHD could be reduced by depleting CD8(+) T cells from the donor lymphocyte concentrate. Alternatively only small numbers of T lymphocytes can be transfused and in the case of failing responses, the numbers of donor lymphocytes may be increased. Results in recurrent AML have been improved by the use of low-dose cytosine arabinoside, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor mobilized blood cells as compared to lymphocytes only. In MMY the response rate is higher than in AML, but the remissions are of limited duration in most patients. Several protocols have been designed to include preemptive donor lymphocyte transfusion in patients with a high relapse risk after transplantation. Problems remain to avoid chronic GVHD and to circumvent the immune escape mechanisms of leukemia. Copyright (C) 2003 S. Karger AG, Basel

Fabrication and characterization of Au dimer antennas on glass pillars with enhanced plasmonic response

We report on the fabrication and dark-field spectroscopy characterization of Au dimer nanoantennas placed on top of SiO2 nanopillars. The reported process enables the fabrication of nanopillar dimers with gaps down to 15 nm and heights up to 1 μm. A clear dependence of the plasmonic resonance position on the dimer gap is observed for smaller pillar heights, showing the high uniformity and reproducibility of the process. It is shown how increasing the height of nanopillars significantly affects the recorded elastic scattering spectra from Au nanoantennas. The results are compared to finite-difference time-domain (FDTD) and finite-element method (FEM) simulations. Additionally, measured spectra are accompanied by dark-field microscopy images of the dimers, showing the pronounced change in color. Placing nanoantennas on nanopillars with a height comparable to the in-plane dimer dimensions results in an enhancement of the scattering response, which can be understood through reduced interaction of the near-fields with the substrate. When increasing the pillar height further, scattering by the pillars themselves manifests itself as a strong tail at lower wavelengths. Additionally, strong directional scattering is expected as a result of the interface between the nanoantennas and nanopillars, which is taken into account in simulations. For pillars of height close to the plasmonic resonance wavelength, the scattering spectra become more complex due to additional scattering peaks as a result of larger geometrical nonuniformities