The Electrochemical Reduction Of Nicotinamide-adenine Dinucleotide And Related Compounds.

PhDAnalytical chemistryUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/186717/2/7123869.pd

Nicotinamide-NAD sequence: electrochemical and allied chemical behavior

Electrochemical redox mechanisms in aqueous and non-aqueous media, including associated chemical reactions, structure and behaviour of intermediate species, and phenomena such as adsorption, have been elucidated for a sequence of compounds ranging from nicotinamide to NAD+. Dimerization rates of the free radicals, produced on the initial one-electron reduction, have been measured. The electrochemical behaviour has been correlated with structural, solvation, molecular orbital and other pertinent characteristics and parameters.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22445/1/0000897.pd

254 - Effect of the Adenine Moiety on the Electrochemical Behavior of Nicotinamide Adenine Dinucleotide; Possible Reduction of the Adenine

The presence of the adenine moiety very markedly affects the adsorption phenomena at the solution|electrode interface associated with nicotinamide adenine dinucleotide (NAD+) in aqueous media. Furthermore, a number of effects seen on the electrochemical reduction of NAD+ may be associated with faradaic reduction of the adenine. Such a reduction, which has been postulated as an initial step in the pulse radiolysis of NAD+, helps to rationalize the reversible reduction of adsorbed NAD+, where the ultimate reduction site, i.e., the pyridine ring, is separated from the solution|electrode interface by the adenine ring. The adenine moiety also participates in a redox couple with mercury.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22761/1/0000316.pd