Update of complications and functional outcome of the ileo-pouch anal anastomosis: overview of evidence and meta-analysis of 96 observational studies

Item does not contain fulltextOBJECTIVE: The objective of this study is to provide a comprehensive update of the outcome of the ileo-pouch anal anastomosis (IPAA). DATA SOURCES: An extensive search in PubMed, EMBASE, and The Cochrane Library was conducted. STUDY SELECTION AND DATA EXTRACTION: All studies published after 2000 reporting on complications or functional outcome after a primary open IPAA procedure for UC or FAP were selected. Study characteristics, functional outcome, and complications were extracted. DATA SYNTHESIS: A review with similar methodology conducted 10 years earlier was used to evaluate developments in outcome over time. Pooled estimates were compared using a random-effects logistic meta-analyzing technique. Analyses focusing on the effect of time of study conductance, centralization, and variation in surgical techniques were performed. RESULTS: Fifty-three studies including 14,966 patients were included. Pooled rates of pouch failure and pelvic sepsis were 4.3% (95% CI, 3.5-6.3) and 7.5% (95% CI 6.1-9.1), respectively. Compared to studies published before 2000, a reduction of 2.5% was observed in the pouch failure rate (p = 0.0038). Analysis on the effect of the time of study conductance confirmed a decline in pouch failure. Functional outcome remained stable over time, with a 24-h defecation frequency of 5.9 (95% CI, 5.0-6.9). Technical surgery aspects did not have an important effect on outcome. CONCLUSION: This review provides up to date outcome estimates of the IPAA procedure that can be useful as reference values for practice and research. It is also shows a reduction in pouch failure over time.1 juli 201

Impacts of technology on summative and self-assessment: does more technology in a secondary math classroom increase students' test scores?

Plan B Paper. 2014. Master of Science in Education- Mathematics--University of Wisconsin-River Falls. Teacher Education Department. 35 leaves. Includes bibliographical references (leaf 25).This study examines the effects on students when the instructor is introducing technology in the math classroom, by taking advantage of a favorable opportunity to study two populations with highly contrasted levels of access to technology. White Bear Lake High School went from minimal technology in 2010 to a school infused with technology by 2013.The instructor applied for a grand to receive a smartboard which was approved. Also, the instructor received a classroom set of graphing calculators that students could use in class and check out to bring home. Students' achievement on a unit test in Algebra 2 and their overall attitude towards the technology were analyzed for two populations. A control group of 63 students from an Algebra 2 class in 2010 had minimal technology available. These students did not have access to graphing calculators and the instructor taught on an overhead projector. A treatment group from 2013 of Algebra 2 students had significantly increased access to technology. This treatment group had a class website with math resources tailored to eat class, a set of graphing calculators, an interactive whiteboard and the use of smartphones. The mean score on the unit tests was 32 for both populations and the treatment group had a median of one point higher than the control group. The students in this study who had access to technology self-reported a high level of enjoyment using that technology to solve problems. The instructor reported that students complained less about doing longer math problems when they had access to technology

Competitive diffusion and adsorption in Vycor glass membranes - A lumped parameter approach

The interaction of simultaneous diffusion and adsorption of pure gases and gas mixtures in a Vycor glass membrane has been studied under transient conditions in a modified Wicke-Kallenbach cell. A lumped two parameter approach was developed in order to analyse all the observed pressure responses in a unified manner. This approach was found to be capable to fit well almost all the observations made for different types of gases and at different temperatures with sufficient or excellent accuracy. (c) 2006 Elsevier B.V. All rights reserved

Bewertungskriterien fuer eine integrierte Betrachtungsweise des Oekosystems "Stadt"

Available from Bibliothek des Instituts fuer Weltwirtschaft, ZBW, D-21400 Kiel W 858 (78) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Delayed Kock pouch nipple valve failure: is revision indicated?

PURPOSE: This study was designed to review our experience with patients who, after more than 10 years of normal Kock pouch valve function, required repair of the valve. In addition, we describe the surgical techniques employed for valve repair. METHODS: A retrospective chart review identified 31 patients who underwent Kock pouch revision after a minimum time interval between previous pouch surgery and the current revision of 10 (average, 19.7) years. RESULTS: The intraoperative findings included slipped valve, valve prolapse, and internal nipple valve fistulas. The procedures performed included standard valve reconstruction, turnaround procedures, pedicle repair, wall stapling, and oversewing of fistula. Twelve of the 31 patients failed the initial revision and required additional operations, with an overall pouch salvage success rate of 93 percent. Only two patients required excision of the pouch and conversion to a Brooke ileostomy. The procedures were performed with minimal morbidity and no mortality. CONCLUSION: Surgical revision can be offered to patients with a continent ileostomy complicated by delayed valve dysfunction with low morbidity and good functional outcome

CORBEL Report on ELSI support needs for BMS RIs and towards a joint Ethical Governance Framework

The aim of the deliverable is to ultimately provide CORBEL partners with an Ethical Governance Framework (Annex 2) and Ethics Check procedure (Annex 3) building on the work of the Common Service ELSI of BBMRI-ERIC and the BioMedBridges project. It shall enable the partners to operate within agreed terms with respect to participant consent, ethics committee approvals and national regulations ensuring researchers supply and access data and/or samples whilst working under a common ethical framework. It aims to build a joint policy to address ELSI considerations of biological resource providers as well as to enhance related procedures for the user community of BMS RIs. Ethics requirements 2 (informed consent), 3 (incidental finding policy), 9 (procedures on data collection, etc) and 10 (relevant authorisations) are addressed in the general provisions of the CORBEL Ethical Governance Framework. CORBEL has to monitor the compliance of the Ethical Governance Framework (e.g. statement of adherence). The responsibility to meet these ethics requirements and legal compliance ultimately lies with the individual sample and/or data provider and not with the respective research infrastructures. Prior to implementation, the Ethical Governance Framework (including its templates) require validation of its processes and finally the approval of the Executive Board. The ultimate aim of this Work Package is to establish a single and sustainable support mechanism (Common Service) for all BMS RIs dealing with samples and/or data with ethical, legal and societal implications (ELSI). The submission of this report (D7.1) is an important achievement for reaching this goal