Praktiker an der Universität

Karl Bücher hat nicht nur den Grundstein für die akademische Journalistenausbildung geschaffen. Ebenso war es seine Leistung, in diese Ausbildung vom ersten Tage an Vertreter der journalistischen Praxis zu integrieren. Diese übernahmen Übungsseminare, in denen die Studenten journalistische Beiträge unter praxisähnlichen Bedingungen erarbeiteten. Die Ausbildung erfolgte in den journalistischen Ressorts, die Bücher in seinen eigenen Praktikerjahren im letzten Drittel des 19. Jahrhunderts kennen gelernt hatte; neuere Entwicklungen - wie zum Beispiel der Sportjournalismus - fanden noch keine Berücksichtigung. Die einmal eingeführten Übungsseminare wurden – in ihrer inhaltlichen Struktur weitgehend unverändert – bis zur Einstellung des Lehrbetriebs im April 1945 angeboten

Improved Activation toward Primary Colorectal Cancer Cells by Antigen-Specific Targeting Autologous Cytokine-Induced Killer Cells

Adoptive therapy of malignant diseases with cytokine-induced killer (CIK) cells showed promise in a number of trials; the activation of CIK cells from cancer patients towards their autologous cancer cells still needs to be improved. Here, we generated CIK cells ex vivo from blood lymphocytes of colorectal cancer patients and engineered those cells with a chimeric antigen receptor (CAR) with an antibody-defined specificity for carcinoembryonic antigen (CEA). CIK cells thereby gained a new specificity as defined by the CAR and showed increase in activation towards CEA+ colon carcinoma cells, but less in presence of CEA− cells, indicated by increased secretion of proinflammatory cytokines. Redirected CIK activation was superior by CAR-mediated CD28-CD3ζ than CD3ζ signaling only. CAR-engineered CIK cells from colon carcinoma patients showed improved activation against their autologous, primary carcinoma cells from biopsies resulting in more efficient tumour cell lysis. We assume that adoptive therapy with CAR-modified CIK cells shows improved selectivity in targeting autologous tumour lesions

Die KPD-Tagespresse im Kampf um die Massen eine historische Untersuchung der KPD-Bezirksorgane 'Der Kaempfer', Chemnitz, und 'Klassenkampf', Halle, fuer den Zeitraum 1918 bis 1929

FES Bonn(Bo133)-C89-1154 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Adsorption calorimetric study of the organization of sodium n-decyl sulfate at the graphite/solution interface

The material and enthalpy balances of the adsorption of sodium n-decyl sulfate from aqueous solutions onto graphitized carbon black were determined between 288 and 318 K by using an automated flow sorption/microcalorimeter system. At low concentrations, the surfactant molecules form a flat monomolecular film on the graphite plane, in consequence of surface-directed ordering. A mechanism is proposed in which two adsorbed phases coexist during the formation of this surfactant monolayer. The enthalpy of adsorption in the monolayer region is ca. -42 kJ mol(-1), which does not depend appreciably on the temperature or on the surface coverage. At higher concentrations, the ordered monolayer induces surface aggregation to produce half-cylindrical hemimicelles as the critical micelle concentration is approached. The enthalpies of surface aggregation at 288, 298, and 318 K are -10, -16, and -26 kJ mol(-1), respectively. As the temperature is increased from 288 to 318 K, the average number of surfactant molecules in the cross section of a half-cylinder drops from ca. 5.4 to 3.4. Calorimetric evidence is provided that cationic and anionic surfactant adsorption on graphite follow the same mechanism in the low-density and high-density adsorbate regions