ARC

Tiré de: ARC, spring/summer 1996Bibliogr.: p. 1

The Axis-Ratio Distribution of Galaxy Clusters in the SDSS-C4 Catalog as a New Cosmological Probe

We analyze the C4 catalog of galaxy clusters from the Sloan Digital Sky Survey (SDSS) to investigate the axis-ratio distribution of the projected two dimensional cluster profiles. We consider only those objects in the catalog whose virial mass is close to 10^{14}h^{-1}M_{sun}, with member galaxies within the scale radius 1000 kpc. The total number of such objects turns out to be 336. We also derive a theoretical distribution by incorporating the effect of projection onto the sky into the analytic formalism proposed recently by Lee, Jing, & Suto. The theoretical distribution of the cluster axis-ratios is shown to depend on the amplitude of the linear power spectrum (sigma_8) as well as the density parameter (Omega_{m}). Finally, fitting the observational data to the analytic distribution with Omega_{m} and sigma_{8} as two adjustable free parameters, we find the best-fitting value of sigma_{8}=(1.01 +/- 0.09)(Omega_{m}/0.6)^{(0.07 +/- 0.02) +0.1 Omega_{m}}$. It is a new sigma_{8}-Omega_{m} relation, different from the previous one derived from the local abundance of X-ray clusters. We expect that the axis-ratio distribution of galaxy clusters, if combined with the local abundance of clusters, may put simultaneous constraints on sigma_{8} and Omega_{m}.Comment: accepted for publication in ApJ, 17 pages, 3 figures, improved analysis, more discussion on the validity and the caveats of the mode

Bhutanese Nepalis or Nepali Bhutanese?

Since 1990 Bhutanese of Nepali descent have been forced to leave Bhutan and live as refugees in their ancestral land. Currently, more than 100,000 live in seven UNHCR-assisted refugee camps in the border districts of Jhapa and Morang in eastern Nepal. The Bhutanese government sees them as 'Nepali' and wants them to stay in Nepal, while the Nepalis call them 'Bhutanese' and want them to return. In the midst of this identity crisis, the refugees call themselves 'Bhutanese' - many possess Bhutanese citizenship cards, and want to return. Despite several rounds of talks between Nepal and Bhutan, the refugees remain stateless and their identity remains as obscure as ever

De rib uit zijn lijf. Joodse spreekwoorden en zegswijzen over vrouwen

Interculturele studie van literatuur en samenlevin

The influence of the schedule and the dose of gemcitabine on the anti-tumour efficacy in experimental human cancer.

The therapeutic efficacy of gemcitabine, a new nucleoside analogue, was assessed in a variety of well-established human soft tissue sarcoma and ovarian cancer xenografts grown s.c. in nude mice. Tumour lines selected had different histological subtypes, growth rates and sensitivities to conventional cytostatic agents. The three different doses and schedules designed on the basis of a mean weight loss between 5% and 15% were i.p. injections of daily 3.5 mg kg-1 x 4, every 3 days 120 mg kg-1 x 4, and weekly 240 mg kg-1 x 2, which ultimately resulted in 19%, 10% and 4% toxic deaths, respectively. The weekly schedule induced > or = 50% growth inhibition in 2/4 soft tissue sarcoma and 4/6 ovarian cancer lines, while in three ovarian cancer lines > or = 75% growth inhibition was obtained. The anti-tumour effects of gemcitabine appeared to be similar or even better than previous data with conventional drugs tested in the same tumour lines. In comparison with the every 3 days schedule, the weekly and the daily schedule were less effective in 5/7 and 3/3 tumour lines (P < 0.001), respectively. In another experiment in three human tumour lines selected for their differential sensitivity to gemcitabine, weekly injections of 240 mg kg-1 x 6 did not result in a significant increase in the percentages of growth inhibition when compared to lower doses of 120 mg kg-1 or 60 mg kg-1 in the same schedule. However, the 240 mg kg-1 weekly x 6 schedule showed superior effects in 2/3 tumour lines in comparison with the same dose given every 2 weeks x 3 (P < 0.05). The preclinical activity of gemcitabine suggests that the drug can induce responses in soft tissue sarcoma and ovarian cancer patients. Our results further indicate that clinical trials of gemcitabine in solid tumour types should be designed on the basis of a schedule rather than a dose dependence

The Role of the Gut Microbiota in the Effects of Early-Life Stress and Dietary Fatty Acids on Later-Life Central and Metabolic Outcomes in Mice

Early-life stress (ELS) leads to increased vulnerability for mental and metabolic disorders. We have previously shown that a low dietary ω-6/ω-3 polyunsaturated fatty acid (PUFA) ratio protects against ELS-induced cognitive impairments. Due to the importance of the gut microbiota as a determinant of long-term health, we here study the impact of ELS and dietary PUFAs on the gut microbiota and how this relates to the previously described cognitive, metabolic, and fatty acid profiles. Male mice were exposed to ELS via the limited bedding and nesting paradigm (postnatal day (P)2 to P9 and to an early diet (P2 to P42) with an either high (15) or low (1) ω-6 linoleic acid to ω-3 alpha-linolenic acid ratio. 16S rRNA was sequenced and analyzed from fecal samples at P21, P42, and P180. Age impacted α- and β-diversity. ELS and diet together predicted variance in microbiota composition and affected the relative abundance of bacterial groups at several taxonomic levels in the short and long term. For example, age increased the abundance of the phyla Bacteroidetes, while it decreased Actinobacteria and Verrucomicrobia; ELS reduced the genera RC9 gut group and Rikenella, and the low ω-6/ω-3 diet reduced the abundance of the Firmicutes Erysipelotrichia. At P42, species abundance correlated with body fat mass and circulating leptin (e.g., Bacteroidetes and Proteobacteria taxa) and fatty acid profiles (e.g., Firmicutes taxa). This study gives novel insights into the impact of age, ELS, and dietary PUFAs on microbiota composition, providing potential targets for noninvasive (nutritional) modulation of ELS-induced deficits. IMPORTANCE Early-life stress (ELS) leads to increased vulnerability to develop mental and metabolic disorders; however, the biological mechanisms leading to such programming are not fully clear. Increased attention has been given to the importance of the gut microbiota as a determinant of long-term health and as a potential target for noninvasive nutritional strategies to protect against the negative impact of ELS. Here, we give novel insights into the complex interaction between ELS, early dietary ω-3 availability, and the gut microbiota across ages and provide new potential targets for (nutritional) modulation of the long-term effects of the early-life environment via the microbiota

Broken Symmetry in Density-Functional Theory: Analysis and Cure

We present a detailed analysis of the broken-symmetry mean-field solutions using a four-electron rectangular quantum dot as a model system. Comparisons of the density-functional theory predictions with the exact ones show that the symmetry breaking results from the single-configuration wave function used in the mean-field approach. As a general cure we present a scheme that systematically incorporates several configurations into the density-functional theory and restores the symmetry. This cure is easily applicable to any density-functional approach.Comment: 4 pages, 4 figures, submitted to PR