Time without time: a stochastic clock model

We study a classical reparametrization-invariant system, in which ``time'' is not a priori defined. It consists of a nonrelativistic particle moving in five dimensions, two of which are compactified to form a torus. There, assuming a suitable potential, the internal motion is ergodic or more strongly irregular. We consider quasi-local observables which measure the system's ``change'' in a coarse-grained way. Based on this, we construct a statistical timelike parameter, particularly with the help of maximum entropy method and Fisher-Rao information metric. The emergent reparametrization-invariant ``time'' does not run smoothly but is simply related to the proper time on the average. For sufficiently low energy, the external motion is then described by a unitary quantum mechanical evolution in accordance with the Schr\"odinger equation.Comment: 18 pages; LaTeX. 4 (.ps) plus 2 (.gif) figure file

Effects of a second phase on the tribological properties of Al2O3 and ZrO2 ceramics

The tribological properties of four different materials are investigated, tetragonal zirconia (Y-ZTP), Al2O3 dispersed in Y-TZP (ADZ), ZrO2 dispersed in Al2O3 (ZTA) and Al2O3 (with 300 ppm MgO). These materials are used as a cylinder sliding against a plate of Y-TZP (TZ-3Y)). Compared to Y-TZP, the wear resistance of ADZ composites is increased by a factor of 4¿10. At a contact pressure of 230 MPa, a wear transition for Y-TZP is observed from plastic deformation to microchipping and microfracture due to the high interfacial temperature (450°C¿550°C) generated by frictional heating. Because of the higher elastic modulus, hardness and fracture toughness at high temperature, ADZ composites show better wear resistance and a higher transition contact pressure (over 400 MPa) under the present conditions. For Al2O3, the transition from mild to severe wear occurs when the contact pressure is changed from 250 to 400 MPa. For ZTA ceramics, the wear behaviour does not change because of the presence of a compressive layer due to the zirconia phase transformation during sliding.\ud \ud In water the wear resistance for ADZ and ZY5 is almost two orders of magnitude higher than the results under dry conditions. Reduction of the interfacial temperature by using water and the formation of a hydroxide layer at the contact surface by the tribochemical reaction of water with the ceramic, as observed by XPS, gives a positive effect on wear resistance

Friction and wear behaviour of ceramic-hardened steel couples under reciprocating sliding motion

The friction and wear behaviour of ZrO2-Y203, ZrO2-Y203-CeO2 and ZrO2-A1203 composite ceramics against hardened steel AISI-52100 were investigated using a pin on plate configuration under reciprocating motion. The reproducibility of the results was examined in this configuration. Wear characteristics were separated into system and material contributions. Under the conditions used, all the ceramic components exhibited rather low wear rates (less than 10-6mm3N-1m-1). The frictional behaviour of ceramic-metal couples depended on a metallic layer transferred from the steel plate to the ceramic pin. A relation was determined between surface hardness and friction of ceramic-metal pairs. It was shown that the affinity for the transfer of the metal towards ceramic surfaces depended on the physical properties of the materials. In the tribosystems investigated, the effect of the hardness of the ceramics on friction and wear behaviour is found to be more important than that of toughness of the ceramics

Robuustheid in een samengesteld mobiliteitssysteem; over tijdelijke optima en gelaagde bestuurskundige uitdagingen

Zowel in mobiliteitsonderzoek als in de beleidspraktijk valt er recentelijk een onmiskenbaar streven naar 'robuustheid' waar te nemen. Dit streven is vaak een reactie op een als zeer dynamisch ervaren omgeving. Het is daarbij echter opvallend dat er zeer uiteenlopende invullingen aan dit concept worden gegeven. Dit roept de vraag op of het concept ‘robuustheid’ wel van toegevoegde waarde is voor het bestuur in het mobiliteitsdomein. Maar vooral roept het de vraag op hoe het dat kan zijn. In deze bijdrage wordt geredeneerd vanuit de complexiteit van een samengesteld mobiliteitssysteem: De gehanteerde premisse is dat pogingen om mobiliteit te sturen of te beïnvloeden plaatsvinden in dynamische en slechts deels controleerbare omgevingen. Het streven naar robuustheid is zo beschouwd dus begrijpelijk, maar ook inherent moeizaam. De centrale vraag die moet worden beantwoord is: “Hoe kan het concept ‘robuustheid’ helpen richting te geven aan het handelen in een samengesteld, gelaagd en padafhankelijk mobiliteitssysteem?” De vraag wordt beantwoord vanuit een theoretische reflectie op de verschillende verschijningsvormen en interpretaties van ‘robuustheid’. Vanuit onze empirie (in zowel weg, water als rail) komt dan naar voren dat robuustheid soms meer en soms minder dynamisch wordt ingevuld, dat soms fysieke, soms juist sociale dimensies worden benadrukt, en dat het onder uiteenlopende randvoorwaarden wordt vormgegeven. Daarbij valt ook op dat robuustheid in deelsystemen niet altijd tot algehele robuustheid leidt, en vaak deeloplossingen biedt. Sterker nog, in de meer omvattende analyses van het mobiliteitssysteem is de systemische robuustheid eerder deel van het probleem dan de oplossing. Op ‘robuustheid’ gericht mobiliteitsbeleid betreft gewoonlijk het managen van deelsystemen. Deze doorgaans lokale en tijdelijke robuustheid zal bijsturing, onderhoud en aanpassing vergen. Maar daarbij zal ook beseft moeten worden dat deze robuustheid gelijktijdig weer deel uitmaakt van een gelaagd, vervlochten en in sommige opzichten ook wel hardnekkig mobiliteitssysteem

The influence of the schedule and the dose of gemcitabine on the anti-tumour efficacy in experimental human cancer.

The therapeutic efficacy of gemcitabine, a new nucleoside analogue, was assessed in a variety of well-established human soft tissue sarcoma and ovarian cancer xenografts grown s.c. in nude mice. Tumour lines selected had different histological subtypes, growth rates and sensitivities to conventional cytostatic agents. The three different doses and schedules designed on the basis of a mean weight loss between 5% and 15% were i.p. injections of daily 3.5 mg kg-1 x 4, every 3 days 120 mg kg-1 x 4, and weekly 240 mg kg-1 x 2, which ultimately resulted in 19%, 10% and 4% toxic deaths, respectively. The weekly schedule induced > or = 50% growth inhibition in 2/4 soft tissue sarcoma and 4/6 ovarian cancer lines, while in three ovarian cancer lines > or = 75% growth inhibition was obtained. The anti-tumour effects of gemcitabine appeared to be similar or even better than previous data with conventional drugs tested in the same tumour lines. In comparison with the every 3 days schedule, the weekly and the daily schedule were less effective in 5/7 and 3/3 tumour lines (P < 0.001), respectively. In another experiment in three human tumour lines selected for their differential sensitivity to gemcitabine, weekly injections of 240 mg kg-1 x 6 did not result in a significant increase in the percentages of growth inhibition when compared to lower doses of 120 mg kg-1 or 60 mg kg-1 in the same schedule. However, the 240 mg kg-1 weekly x 6 schedule showed superior effects in 2/3 tumour lines in comparison with the same dose given every 2 weeks x 3 (P < 0.05). The preclinical activity of gemcitabine suggests that the drug can induce responses in soft tissue sarcoma and ovarian cancer patients. Our results further indicate that clinical trials of gemcitabine in solid tumour types should be designed on the basis of a schedule rather than a dose dependence

Broken Symmetry in Density-Functional Theory: Analysis and Cure

We present a detailed analysis of the broken-symmetry mean-field solutions using a four-electron rectangular quantum dot as a model system. Comparisons of the density-functional theory predictions with the exact ones show that the symmetry breaking results from the single-configuration wave function used in the mean-field approach. As a general cure we present a scheme that systematically incorporates several configurations into the density-functional theory and restores the symmetry. This cure is easily applicable to any density-functional approach.Comment: 4 pages, 4 figures, submitted to PR

Sporting programs for inactive population groups:factors influencing implementation in the organized sports setting

BACKGROUND: The organized sports sector has received increased attention as a setting to promote health-enhancing physical activity (HEPA) to the general population. For significant public health impact, it is important that successful HEPA programs are widely adopted, implemented and continued as ongoing practice. The importance of evaluating the context in which programs are implemented has been identified as critical. However, little research has focused on understanding the organized sports implementation context, including factors facilitating and impeding implementation. In this study, the main factors influencing implementation of HEPA programs in the organized sports setting were studied. METHODS: Fourteen sporting programs in the Netherlands aimed at increasing participation in sports by inactive population groups and funded within the National Action Plan for Sport and Exercise (NAPSE) were investigated. The programs were developed by ten Dutch National Sports Federations (NSFs) and implemented by different sports clubs in the Netherlands over a 3-year implementation period (June 2008-June 2011). The qualitative research component involved yearly face-to-face interviews (i.e. fourteen interviews each year, n = 12 program coordinators) and a group meeting with the program coordinators of the NSFs (n = 8). Cross-case comparisons and thematic analyses were performed to identify and categorize important facilitating and impeding factors respectively. The quantitative research component, used to identify the most important facilitating and impeding factors across all sporting programs, consisted of ranking of factors according to importance by the program coordinators (n = 12). RESULTS: Different factors act during six identified (implementation) phases. When comparing factors across phases, several key learnings were evident. Successful implementation relied, for example, on program design and enthusiastic individuals within sporting organizations. On the other hand, inactive people were hard to reach and participation of sports clubs was not self-evident. The findings were discussed in a broader context. CONCLUSIONS: This study adds to the knowledge base concerning the implementation of sporting programs, aimed at inactive people, in the organized sports setting. The main factors facilitating and impeding implementation were identified. The results of this study can be used by sports practitioners and policy makers when developing and implementing HEPA programs in this setting