8,509 research outputs found
Translational cooling and storage of protonated proteins in an ion trap at subkelvin temperatures
Gas-phase multiply charged proteins have been sympathetically cooled to
translational temperatures below 1 K by Coulomb interaction with laser-cooled
barium ions in a linear ion trap. In one case, an ensemble of 53 cytochrome c
molecules (mass ~ 12390 amu, charge +17 e) was cooled by ~ 160 laser-cooled
barium ions to less than 0.75 K. Storage times of more than 20 minutes have
been observed and could easily be extended to more than an hour. The technique
is applicable to a wide variety of complex molecules.Comment: same version as published in Phys. Rev.
Ellipsoidal Coulomb Crystals in a Linear Radiofrequency Trap
A static quadrupole potential breaks the cylindrical symmetry of the
effective potential of a linear rf trap. For a one-component fluid plasma at
low temperature, the resulting equilibrium charge distribution is predicted to
be an ellipsoid. We have produced laser-cooled Be ellipsoidal ion crystals
and found good agreement between their shapes and the cold fluid prediction. In
two-species mixtures, containing Be and sympathetically cooled ions of
lower mass, a sufficiently strong static quadrupole potential produces a
spatial separation of the species.Comment: 4 pages, 3 figure
Precision spectroscopy of the molecular ion HD+: control of Zeeman shifts
Precision spectroscopy on cold molecules can potentially enable novel tests
of fundamental laws of physics and alternative determination of some
fundamental constants. Realizing this potential requires a thorough
understanding of the systematic effects that shift the energy levels of
molecules. We have performed a complete ab initio calculation of the magnetic
field effects for a particular system, the heteronuclear molecular hydrogen ion
HD+. Different spectroscopic schemes have been considered, and numerous
transitions, all accessible by modern radiation sources and exhibiting well
controllable or negligible Zeeman shift, have been found to exist. Thus, HD+ is
a perspective candidate for determination of the ratio of electron-to-nuclear
reduced mass, and for tests of its time-independence.Comment: A Table added, references and figures update
Real-time dynamics in Quantum Impurity Systems: A Time-dependent Numerical Renormalization Group Approach
We develop a general approach to the nonequilibrium dynamics of quantum
impurity systems for arbitrary coupling strength. The numerical renormalization
group is used to generate a complete basis set necessary for the correct
description of the time evolution. We benchmark our method with the exact
analytical solution for the resonant-level model. As a first application, we
investigate the equilibration of a quantum dot subject to a sudden change of
the gate voltage and external magnetic field. Two distinct relaxation times are
identified for the spin and charge dynamics.Comment: 5 pages, 5 figure
Caring Without Sharing: Philanthropy\u27s Creation and Destruction of the Common World
This dissertation explores multiple ways philanthropy builds and undermines the common world. Political science treatments of philanthropy have focused mainly on its role in the development of civil society, with a recent turn towards critiques of philanthropy as an instrument of elite power and tension between private wealth and democratic governance. In this dissertation, I examine how philanthropy can foster enduring spaces of human flourishing, or reduce beneficiaries to objects of pity, surveillance and domination. I trace philanthropy\u27s evolution from ancient to contemporary contexts and propose a framework for philanthropy to, under certain conditions, build and care for the common world, where philanthropic gifts create and maintain enduring spaces and institutions that allow the public realm to be the domain of appearance and plurality. Hannah Arendt translates philanthropia as “a readiness to share the world with other men.” Using Arendt, this dissertation proposes a new framework for political theories of philanthropy, one that can determine its role in public life based on donors’ commitment to an enduring world and to sharing with others the responsibility for its care
Sympathetic cooling of He ions in a radiofrequency trap
We have generated Coulomb crystals of ultracold He ions in a linear
radiofrequency trap, by sympathetic cooling via laser--cooled Be.
Stable crystals containing up to 150 localized He ions at 20 mK were
obtained. Ensembles or single ultracold He ions open up interesting
perspectives for performing precision tests of QED and measurements of nuclear
radii. The present work also indicates the feasibility of cooling and
crystallizing highly charged atomic ions using Be as coolant.Comment: 4 pages, 2 figure
Ultracold electron bunch generation via plasma photocathode emission and acceleration in a beam-driven plasma blowout
Beam-driven plasma wakefield acceleration using low-ionization-threshold gas such as Li is combined with laser-controlled electron injection via ionization of high-ionization-threshold gas such as He. The He electrons are released with low transverse momentum in the focus of the copropagating, nonrelativistic-intensity laser pulse directly inside the accelerating or focusing phase of the Li blowout. This concept paves the way for the generation of sub-μm-size, ultralow-emittance, highly tunable electron bunches, thus enabling a flexible new class of an advanced free electron laser capable high-field accelerator. © 2012 American Physical Society
Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study.
BACKGROUND:Patients with chronic kidney disease (CKD) are at increased risk for heart failure (HF). We aimed to investigate differences in proteins associated with HF hospitalizations among patients with and without CKD in the Heart and Soul Study. METHODS AND RESULTS:We measured 1068 unique plasma proteins from baseline samples of 974 participants in The Heart and Soul Study who were followed for HF hospitalization over a median of 7 years. We sequentially applied forest regression and Cox survival analyses to select prognostic proteins. Among participants with CKD, four proteins were associated with HF at Bonferroni-level significance (p<2.5x10(-4)): Angiopoietin-2 (HR[95%CI] 1.45[1.33, 1.59]), Spondin-1 (HR[95%CI] 1.13 [1.06, 1.20]), tartrate-resistant acid phosphatase type 5 (HR[95%CI] 0.65[0.53, 0.78]) and neurogenis locus notch homolog protein 1 (NOTCH1) (HR[95%CI] 0.67[0.55, 0.80]). These associations persisted at p<0.01 after adjustment for age, estimated glomerular filtration and history of HF. CKD was a significant interaction term in the associations of NOTCH1 and Spondin-1 with HF. Pathway analysis showed a trend for higher representation of the Cardiac Hypertrophy and Complement/Coagulation pathways among proteins prognostic of HF in the CKD sub-group. CONCLUSIONS:These results suggest that markers of heart failure differ between patients with and without CKD. Further research is needed to validate novel markers in cohorts of patients with CKD and adjudicated HF events
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