Polydimethylsiloxane based microfluidic diode

In this paper, we present a novel elastomer-based microfluidic device for rectifying flow. The device is analogous to an electronic diode in function since it allows flow in one direction and stops flow in the opposing direction. The device is planar, in-line and can be replica molded via standard soft lithography techniques. The fabrication process is outlined in detail and follows a simple procedure that requires only photolithography and one replica molding step. Several geometries of devices are presented along with their flow versus pressure characteristics. A brief discussion of the device behavior is presented along with possible uses for the device

Classical Physics and Quantum Loops

The standard picture of the loop expansion associates a factor of h-bar with each loop, suggesting that the tree diagrams are to be associated with classical physics, while loop effects are quantum mechanical in nature. We discuss examples wherein classical effects arise from loop contributions and display the relationship between the classical terms and the long range effects of massless particles.Comment: 15 pages, 3 figure

Characterization of Alkali Metal Dispensers and Non-Evaporable Getter Pumps in Ultra-High Vacuum Systems for Cold Atomic Sensors

A glass ultrahigh vacuum chamber with rubidium alkali metal dispensers and non-evaporable getter pumps has been developed and used to create a cold atomic sample in a chamber that operates with only passive vacuum pumps. The ion-mass spectrum of evaporated gases from the alkali metal dispenser has been recorded as a function of dispenser current. The efficacy of the non-evaporable getter pumps in promoting and maintaining vacuum has been characterized by observation of the Rb vapor optical absorption on the D2 transition at 780 nm and vacuum chamber pressure rate of rise tests. We have demonstrated a sample of laser-cooled Rb atoms in this chamber when isolated and operating without active vacuum pumps

Critical points in a relativistic bosonic gas induced by the quantum structure of spacetime

It is well known that phase transitions arise if the interaction among particles embodies an attractive as well as a repulsive contribution. In this work it will be shown that the breakdown of Lorentz symmetry, characterized through a deformation in the relation dispersion, plus the bosonic statistics predict the emergence of critical points. In other words, in some quantum gravity models the structure of spacetime implies the emergence of critical points even when no interaction among the particle has been considered.Comment: 5 pages, no figure

Ultranarrow conducting channels defined in GaAs-AlGaAs by low-energy ion damage

We have laterally patterned the narrowest conducting wires of two-dimensional electron gas (2DEG) material reported to date. The depletion induced by low-energy ion etching of GaAs-AlGaAs 2DEG structures was used to define narrow conducting channels. We employed high voltage electron beam lithography to create a range of channel geometries with widths as small as 75 nm. Using ion beam assisted etching by Cl2 gas and Ar ions with energies as low as 150 eV, conducting channels were defined by etching only through the thin GaAs cap layer. This slight etching is sufficient to entirely deplete the underlying material without necessitating exposure of the sidewalls that results in long lateral depletion lengths. At 4.2 K, without illumination, our narrowest wires retain a carrier density and mobility at least as high as that of the bulk 2DEG and exhibit quantized Hall effects. Aharonov–Bohm oscillations are seen in rings defined by this controlled etch-damage patterning. This patterning technique holds promise for creating one-dimensional conducting wires of even smaller sizes

Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer’s disease phenotype in mice

Biological aging can be described as accumulative, prolonged metabolic stress and is the major risk factor for cognitive decline and Alzheimer’s disease (AD). Recently, we identified and described a quinone reductase 2 (QR2) pathway in the brain, in which QR2 acts as a removable memory constraint and metabolic buffer within neurons. QR2 becomes overexpressed with age, and it is possibly a novel contributing factor to age-related metabolic stress and cognitive deficit. We found that, in human cells, genetic removal of QR2 produced a shift in the proteome opposing that found in AD brains while simultaneously reducing oxidative stress. We therefore created highly specific QR2 inhibitors (QR2is) to enable evaluation of chronic QR2 inhibition as a means to reduce biological age–related metabolic stress and cognitive decline. QR2is replicated results obtained by genetic removal of QR2, while local QR2i microinjection improved hippocampal and cortical-dependent learning in rats and mice. Continuous consumption of QR2is in drinking water improved cognition and reduced pathology in the brains of AD-model mice (5xFAD), with a noticeable between-sex effect on treatment duration. These results demonstrate the importance of QR2 activity and pathway function in the healthy and neurodegenerative brain and what we believe to be the great therapeutic potential of QR2is as first-in-class drugs

The extraordinary Hall effect in coherent epitaxial tau (Mn,Ni)Al thin films on GaAs

Ultrathin coherent epitaxial films of ferromagnetic tau(Mn,Ni)0.60Al0.40 have been grown by molecular beam epitaxy on GaAs substrates. X-ray scattering and cross-sectional transmission electron microscopy measurements confirm that the c axis of the tetragonal tau unit cell is aligned normal to the (001) GaAs substrate. Measurements of the extraordinary Hall effect (EHE) show that the films are perpendicularly magnetized, exhibiting EHE resistivities saturating in the range of 3.3-7.1 muOMEGA-cm at room temperature. These values of EHE resistivity correspond to signals as large as +7 and -7 mV for the two magnetic states of the film with a measurement current of 1 mA. Switching between the two magnetic states is found to occur at distinct field values that depend on the previously applied maximum field. These observations suggest that the films are magnetically uniform. As such, tau(Mn,Ni)Al films may be an excellent medium for high-density storage of binary information

Grin and bear it: An examination of volunteers’ fit with their organization, burnout and spirituality

Volunteers are an essential asset to the success of nonprofits, government, business and philanthropic organizations. About 64.5 million people, or 26.5% of the U.S. population, volunteered at least once between September 2011 and September 2012, donating a median of 50 hours (Bureau of Labor Statistics, 2013). Despite these encouraging statistics, volunteer turnover presents a significant problem for nonprofits. Though considerable evidence has been amassed on antecedents and mechanisms predicting employees’ intentions to quit, surprisingly few studies have examined volunteer intentions to quit. Based on both Conservation of Resources theory (Hobfoll, 1989, 2001, 2011) and person–organization (PO) fit theory (Kristof-Brown, Zimmerman, & Johnson, 2005), this study begins to address this void by examining the extent to which poor PO fit between volunteer goals, personality and values with their organization influenced their intentions to quit through the mechanism of burnout. Further, we investigated whether the proposed mediated relationship depended upon volunteer daily spirituality, or the tendency to daily experience the transcendent dimensions of life. Using a sample of volunteers from a variety of nonprofit organizations (N = 355), poor volunteer fit positively predicted volunteer intentions to quit through their burnout. Further, the fullmediationmodel wasmoderated by individuals’ level of spirituality, with burned out volunteers reporting higher spirituality, indicating lower quitting intentions compared to those lower in spirituality. Implications for theory and practice are discussed

Exploring Cognitive States: Methods for Detecting Physiological Temporal Fingerprints

Cognitive state detection and its relationship to observable physiologically telemetry has been utilized for many human-machine and human-cybernetic applications. This paper aims at understanding and addressing if there are unique psychophysiological patterns over time, a physiological temporal fingerprint, that is associated with specific cognitive states. This preliminary work involves commercial airline pilots completing experimental benchmark task inductions of three cognitive states: 1) Channelized Attention (CA); 2) High Workload (HW); and 3) Low Workload (LW). We approach this objective by modeling these "fingerprints" through the use of Hidden Markov Models and Entropy analysis to evaluate if the transitions over time are complex or rhythmic/predictable by nature. Our results indicate that cognitive states do have unique complexity of physiological sequences that are statistically different from other cognitive states. More specifically, CA has a significantly higher temporal psychophysiological complexity than HW and LW in EEG and ECG telemetry signals. With regards to respiration telemetry, CA has a lower temporal psychophysiological complexity than HW and LW. Through our preliminary work, addressing this unique underpinning can inform whether these underlying dynamics can be utilized to understand how humans transition between cognitive states and for improved detection of cognitive states