CONVERGENCE AS METHODOLOGICAL BASIS FOR DEVELOPMENT OF TRANS-PROFESSIONALISM OF ACTIVITY SUBJECTS

Purpose of the study: The need for knowledge, skills, expanding the established functionality of a professional is increasing more and more. That is why young professionals-trans-professionals, who are able to realize themselves not only in one sphere but who are ready to delve into problems of other, absolutely "foreign" for the scientific and technical fields and cooperate effectively with specialists of these areas in one team, will be responsible for creation of new technologies determining the wellness of our country. The article is aimed at the analysis and generalization of foundations of the convergence and identifying its sense-creating content in the development of trans-professionalism as an integral characteristic of the activity subject in a rapidly changing social-professional environment. Methodology: The leading methods in the study of this problem are the theoretical and methodological analysis of the subject and the problem of the research based on the study and logical generalization of scientific literature. Description of the phenomenon of convergence and trans-professionalism was carried out based on multidimensional, transdisciplinary, project and process approaches. Results: The results of the study are content components of trans-professionalism of the activity subject, justification of the convergence theory as a fundamental basis of integration of educational content and new technologies as well as technology foresight of the formation of trans-professionalism of subjects on the basis of convergence. Applications of this study: Materials of the article may be interesting for methodologists, Methodists, and teachers of the continuous professional education system. Novelty/Originality of this study: The components that allow combining the different parameters of the activity subject, showing its qualitative change in the problem field of trans-professionalism, are stated to be the content components of trans-professionalism for activity subjects. The methodology of convergence provides a synergistic effect of the interaction of social-humanitarian and natural sciences. Improving the process of development of trans-professional competencies of activity subjects is associated with the development of new technologies - tools and methods

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or RNASEL in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)-sensing OAS1 and OAS2 generate 2'-5'-linked oligoadenylates (2-5A) that activate the single-stranded RNA-degrading ribonuclease L (RNase L). Monocytic cell lines and primary myeloid cells with OAS1, OAS2, or RNase L deficiencies produce excessive amounts of inflammatory cytokines upon dsRNA or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulation. Exogenous 2-5A suppresses cytokine production in OAS1-deficient but not RNase L-deficient cells. Cytokine production in RNase L-deficient cells is impaired by MDA5 or RIG-I deficiency and abolished by mitochondrial antiviral-signaling protein (MAVS) deficiency. Recessive OAS-RNase L deficiencies in these patients unleash the production of SARS-CoV-2-triggered, MAVS-mediated inflammatory cytokines by mononuclear phagocytes, thereby underlying MIS-C

Factors promoting larch dominance in central Siberia: fire versus growth performance and implications for carbon dynamics at the boundary of evergreen and deciduous conifers

The relative role of fire and of climate in determining canopy species composition and aboveground carbon stocks were investigated. Measurements were made along a transect extending from the dark taiga zone of central Siberia, where <i>Picea</i> and <i>Abies</i> dominate the canopy, into the <i>Larix</i> zone of eastern Siberia. We test the hypotheses that the change in canopy species composition is based (1) on climate-driven performance only, (2) on fire only, or (3) on fire-performance interactions. We show that the evergreen conifers <i>Picea obovata</i> and <i>Abies sibirica</i> are the natural late-successional species both in central and eastern Siberia, provided there has been no fire for an extended period of time. There are no changes in performance of the observed species along the transect. Fire appears to be the main factor explaining the dominance of <i>Larix</i> and of soil carbon. Of lesser influence were longitude as a proxy for climate, local hydrology and active-layer thickness. We can only partially explain fire return frequency, which is not only related to climate and land cover, but also to human behavior. <br><br> Stand-replacing fires decreased from 300 to 50 yrs between the Yenisei Ridge and the upper Tunguska. Repeated non-stand-replacing surface fires eliminated the regeneration of <i>Abies</i> and <i>Picea</i>. With every 100 yrs since the last fire, the percentage of <i>Larix</i> decreased by 20%. <br><br> Biomass of stems of single trees did not show signs of age-related decline. Relative diameter increment was 0.41 ± 0.20% at breast height and stem volume increased linearly over time with a rate of about 0.36 t C ha<sup>−1</sup> yr<sup>−1</sup> independent of age class and species. Stand biomass reached about 130 t C ha<sup>−1</sup>(equivalent to about 520 m<sup>3</sup> ha<sup>−1</sup>). Individual trees of <i>Larix</i> were older than 600 yrs. The maximum age and biomass seemed to be limited by fungal rot of heart wood. 60% of old <i>Larix</i> and <i>Picea</i> and 30% of <i>Pinus sibirica</i> trees were affected by stem rot. Implications for the future role of fire and of plant diseases are discussed

Diffuse cutaneous melanosis associated with malignant melanoma

If the variance of a Gaussian spin-glass Hamiltonian grows like the volume the model fulfills the Ghirlanda-Guerra identities in terms of the normalized Hamiltonian covariance. 1