86 research outputs found
Π’Π΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½ΠΈΡ Π²ΠΎΠ΄ΠΎΠΏΡΠΈΡΠΎΠΊΠ° Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ Π²ΡΡΠΎΠΊΠΎΠ²ΡΠ·ΠΊΠΈΡ Π½Π΅ΡΡΠ΅ΠΉ
ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Ρ ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° Π² Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΎΠ±ΡΠ΅ΠΊΡΠ°Ρ Π²ΠΎΠ»ΡΡΠ°ΠΌΠΏΠ΅ΡΠΎΠΌΠ΅ΡΡΠΈΠ΅ΠΉ
Π€ΠΎΡΠΌΠ°Π»ΠΈΠ·Π°ΡΠΈΡ ΡΠ³Π»Π΅Π²ΠΎΠ΄ΠΎΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΠΏΡΠΎΡΠ΅ΡΡΠ° ΡΠ΅ΠΎΡΠΎΡΠΌΠΈΠ½Π³
ΠΠ½Π°Π»ΠΈΠ· Π²Π»ΠΈΡΠ½ΠΈΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΉ ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΠΊΠΈ Π½Π° ΠΎΠΊΡΡΠΆΠ°ΡΡΡΡ ΡΡΠ΅Π΄Ρ
ΠΠ° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π½ΡΡ
ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ² ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· Π²Π»ΠΈΡΠ½ΠΈΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΉ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΠΊΠΈ Π½Π° ΠΎΠΊΡΡΠΆΠ°ΡΡΡΡ ΡΡΠ΅Π΄Ρ. Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ Π²Π»ΠΈΡΠ½ΠΈΡ ΡΡΡΡ
Π²ΠΈΠ΄ΠΎΠ² ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΠΊΠΈ. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΠΎΠΊΡΡΠΆΠ°ΡΡΡΡ ΡΡΠ΅Π΄Ρ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ Π²ΠΈΠ΄Π° ΠΏΠΎ ΠΎΡΠ΄Π΅Π»ΡΠ½ΠΎΡΡΠΈ. ΠΡΡΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΠ΅Π»ΠΎΠ²Π΅ΡΠ΅ΡΡΠ²ΠΎ Π΄ΠΎ ΡΠΈΡ
ΠΏΠΎΡ Π½Π΅ ΡΠΎΠ·Π΄Π°Π»ΠΎ ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΡΠΈΡΡΡΡ
ΡΠΏΠΎΡΠΎΠ±ΠΎΠ² ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΡΠ½Π΅ΡΠ³ΠΈΠΈ ΠΈ ΡΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΠΈ Π½Π΅ Π²ΠΎΠ·ΠΎΠ±Π½ΠΎΠ²Π»ΡΠ΅ΠΌΡΡ
ΡΠ΅ΡΡΡΡΠΎΠ².Based on the sources used, the analysis of the influence of the directions of modern energy on the environment was carried out. Influences of three types of power are considered. Effect on the environment of each species separately. It has been revealed that mankind has not yet created environmentally friendly ways of obtaining energy and preserving non-renewable resources
Neutrophil gelatinase-associated lipocalin (NGAL) predicts response to neoadjuvant chemotherapy and clinical outcome in primary human breast cancer
In our previous work we showed that NGAL, a protein involved in the regulation of proliferation and differentiation, is overexpressed in human breast cancer (BC) and predicts poor prognosis. In neoadjuvant chemotherapy (NACT) pathological complete response (pCR) is a predictor for outcome. The aim of this study was to evaluate NGAL as a predictor of response to NACT and to validate NGAL as a prognostic factor for clinical outcome in patients with primary BC. Immunohistochemistry was performed on tissue microarrays from 652 core biopsies from BC patients, who underwent NACT in the GeparTrio trial. NGAL expression and intensity was evaluated separately. NGAL was detected in 42.2% of the breast carcinomas in the cytoplasm. NGAL expression correlated with negative hormone receptor (HR) status, but not with other baseline parameters. NGAL expression did not correlate with pCR in the full population, however, NGAL expression and staining intensity were significantly associated with higher pCR rates in patients with positive HR status. In addition, strong NGAL expression correlated with higher pCR rates in node negative patients, patients with histological grade 1 or 2 tumors and a tumor size <40 mm. In univariate survival analysis, positive NGAL expression and strong staining intensity correlated with decreased disease-free survival (DFS) in the entire cohort and different subgroups, including HR positive patients. Similar correlations were found for intense staining and decreased overall survival (OS). In multivariate analysis, NGAL expression remained an independent prognostic factor for DFS. The results show that in low-risk subgroups, NGAL was found to be a predictive marker for pCR after NACT. Furthermore, NGAL could be validated as an independent prognostic factor for decreased DFS in primary human BC
Long-Term Outcome in a Phase II Study of Regional Hyperthermia Added to Preoperative Radiochemotherapy in Locally Advanced and Recurrent Rectal Adenocarcinomas
Hyperthermia was added to standard preoperative chemoradiation for rectal adenocarcinomas in a phase II study. Patients with T3-4 N0-2 M0 rectal cancer or local recurrences were included. Radiation dose was 54 Gy combined with capecitabine 825 mg/m2 Γ 2 daily and once weekly oxaliplatin 55 mg/m2. Regional hyperthermia aimed at 41.5β42.5 Β°C for 60 min combined with oxaliplatin infusion. Radical surgery with total or extended TME technique, was scheduled at 6β8 weeks after radiation. From April 2003 to April 2008, a total of 49 eligible patients were recruited. Median number of hyperthermia sessions were 5.4. A total of 47 out of 49 patients (96%) had the scheduled surgery, which was clinically radical in 44 patients. Complete tumour regression occurred in 29.8% of the patients who also exhibited statistically significantly better RFS and CSS. Rate of local recurrence alone at 10 years was 9.1%, distant metastases alone occurred in 25.6%, including local recurrences 40.4%. RFS for all patients was 54.8% after 5 years and CSS was 73.5%. Patients with T50 temperatures in tumours above median 39.9 Β°C had better RFS, 66.7% vs. 31.3%, p = 0.047, indicating a role of hyperthermia. Toxicity was acceptable.publishedVersio
ΠΠΎΠ΄Π±ΠΎΡ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΏΠ° ΠΈΠ½ΡΡΠ»ΠΈΠ½Π° Π΄Π»Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π² ΠΈΠ½ΡΡΠ»ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΏΠΎΠΌΠΏΠ΅
ΠΡΠΎΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈΠ½ΡΡΠ»ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΏΠΎΠΌΠΏΡ ΠΈ Π²ΡΠ±ΠΎΡ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΏΠ° ΠΈΠ½ΡΡΠ»ΠΈΠ½Π° Π΄Π»Ρ Π»ΡΠ΄Π΅ΠΉ Ρ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ΠΌ ΡΠ°Ρ
Π°ΡΠ½ΡΠΉ Π΄ΠΈΠ°Π±Π΅Ρ. Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΎΠ±Π·ΠΎΡ Π°Π½Π°Π»ΠΎΠ³ΠΎΠ² ΠΈΠ½ΡΡΠ»ΠΈΠ½Π° ΡΠ»ΡΡΡΠ°ΠΊΠΎΡΠΎΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π² ΠΏΠΎΠΌΠΏΠ΅ ΠΈ Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠ΅ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ Π΄Π»Ρ ΠΊΠΎΡΡΠ΅ΠΊΡΠ½ΠΎΠ³ΠΎ Π²Π²ΠΎΠ΄Π° Π³ΠΎΡΠΌΠΎΠ½Π°-ΠΈΠ½ΡΡΠ»ΠΈΠ½Π° Π² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°.Projection of an insulinic pomp and the choice of optimum type of insulin for people with a disease a diabetes mellitus. In the course of the research the state-of-the-art review of analogs of insulin of ultrashort action in a pomp and writing of the program for correct input of hormone-insulin was carried out to a human body
Development of central nervous system metastases as a first site of metastatic disease in breast cancer patients treated in the neoadjuvant trials GeparQuinto and GeparSixto
Background: The incidence of central nervous system (CNS) metastases in breast cancer patients is rising and has become a major clinical challenge. Only few data are published concerning risk factors for the development of CNS metastases as a first site of metastatic disease in breast cancer patients. Moreover, the incidence of CNS metastases after modern neoadjuvant treatment is not clear.
Methods: We analyzed clinical factors associated with the occurrence of CNS metastases as the first site of metastatic disease in breast cancer patients after neoadjuvant treatment in the trials GeparQuinto and GeparSixto (nβ=β3160) where patients received targeted treatment in addition to taxane and anthracycline-based chemotherapy.
Results: After a median follow-up of 61βmonths, 108 (3%) of a total of 3160 patients developed CNS metastases as the first site of recurrence and 411 (13%) patients had metastatic disease outside the CNS. Thirty-six patients (1%) developed both CNS metastases and other distant metastases as the first site of metastatic disease. Regarding subtypes of the primary tumor, 1% of luminal A-like (11/954), 2% of luminal B-like (7/381), 4% of HER2-positive (34/809), and 6% of triple-negative patients (56/1008) developed CNS metastases as the first site of metastatic disease. In multivariate analysis, risk factors for the development of CNS metastases were larger tumor size (cT3β4; HR 1.63, 95% CI 1.08β2.46, pβ=β0.021), node-positive disease (HR 2.57, 95% CI 1.64β4.04, pβ<β0.001), no pCR after neoadjuvant chemotherapy (HR 2.29, 95% CI 1.32β3.97, pβ=β0.003), and HER2-positive (HR 3.80, 95% CI 1.89β7.64, pβ<β0.001) or triple-negative subtype (HR 6.38, 95% CI 3.28β12.44, pβ<β0.001).
Conclusions: Especially patients with HER2-positive and triple-negative tumors are at risk of developing CNS metastases despite effective systemic treatment. A better understanding of the underlying mechanisms is required in order to develop potential preventive strategies
In vitro effects of imatinib mesylate on radiosensitivity and chemosensitivity of breast cancer cells
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