Christian Converts and Social Protests in Meiji Japan

Nowhere has there been a discussion of the confusion necessarily generated by the rapidity of the change or of the agony created in the lives of many whose attitudes, expectations, and even success depended on the continuance of now abolished institutions. Historians have ignored the settled conditions of most samurai and instead concentrated on the study of the minority of activist samurai leaders who, with the backing of only a few Han (feudal domains) sought to overthrow the old order and whose success in doing so has made the study of the modernization of Japan the prime concern of historians. The history of the Meiji period may have been an overall political and industrial success story, but for a fuller understanding of the conditions of that success it is also necessary to understand "what it was really like" for the members of the old elite to be estranged from the proponents of revolution and what many members did to assure their own social and psychological position in a world they had not expected.In this book the author attempts to show that the impact of the Meiji Restoration destroyed the meaningfulness of the Confucian doctrine for these declasse samurai. Through Christianity, the samurai attempted to revive their status in society by finding a doctrine that offered a meaningful path to power. But in doing so, they had to accept a new theory of social relations. Ultimately, as the convert's understanding of society became totally informed by the Christian doctrine, they accepted a transcendent authority that brought them into conflict with society about them. Therefore, to understand the development of a Christian opposition in Meiji society we must begin with the conversion experience itself

Nicotine in floral nectar pharmacologically influences bumblebee learning of floral features

D.B. was supported by a Marie Curie Intra European Fellowship. L.C. is supported by an ERC Advanced Grant and a Royal Society Wolfson Research Merit Award

In Silico Investigation of Potential Src Kinase Ligands from Traditional Chinese Medicine

Src kinase is an attractive target for drug development based on its established relationship with cancer and possible link to hypertension. The suitability of traditional Chinese medicine (TCM) compounds as potential drug ligands for further biological evaluation was investigated using structure-based, ligand-based, and molecular dynamics (MD) analysis. Isopraeroside IV, 9alpha-hydroxyfraxinellone-9-O-beta-D-glucoside (9HFG) and aurantiamide were the top three TCM candidates identified from docking. Hydrogen bonds and hydrophobic interactions were the primary forces governing docking stability. Their stability with Src kinase under a dynamic state was further validated through MD and torsion angle analysis. Complexes formed by TCM candidates have lower total energy estimates than the control Sacaratinib. Four quantitative-structural activity relationship (QSAR) in silico verifications consistently suggested that the TCM candidates have bioactive properties. Docking conformations of 9HFG and aurantiamide in the Src kinase ATP binding site suggest potential inhibitor-like characteristics, including competitive binding at the ATP binding site (Lys295) and stabilization of the catalytic cleft integrity. The TCM candidates have significantly lower ligand internal energies and are estimated to form more stable complexes with Src kinase than Saracatinib. Structure-based and ligand-based analysis support the drug-like potential of 9HFG and aurantiamide and binding mechanisms reveal the tendency of these two candidates to compete for the ATP binding site

The Beginning Of Modern Social Criticism In Japan: A Study Of The Samuraiand Christian Values: 1867-1891.

PhDHistoryUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/184645/2/6715734.pd

Christian Converts and Social Protests in Meiji Japan

Nowhere has there been a discussion of the confusion necessarily generated by the rapidity of the change or of the agony created in the lives of many whose attitudes, expectations, and even success depended on the continuance of now abolished institutions. Historians have ignored the settled conditions of most samurai and instead concentrated on the study of the minority of activist samurai leaders who, with the backing of only a few Han (feudal domains) sought to overthrow the old order and whose success in doing so has made the study of the modernization of Japan the prime concern of historians. The history of the Meiji period may have been an overall political and industrial success story, but for a fuller understanding of the conditions of that success it is also necessary to understand "what it was really like" for the members of the old elite to be estranged from the proponents of revolution and what many members did to assure their own social and psychological position in a world they had not expected.In this book the author attempts to show that the impact of the Meiji Restoration destroyed the meaningfulness of the Confucian doctrine for these declasse samurai. Through Christianity, the samurai attempted to revive their status in society by finding a doctrine that offered a meaningful path to power. But in doing so, they had to accept a new theory of social relations. Ultimately, as the convert's understanding of society became totally informed by the Christian doctrine, they accepted a transcendent authority that brought them into conflict with society about them. Therefore, to understand the development of a Christian opposition in Meiji society we must begin with the conversion experience itself

An Examination of the Formation of Ken and Fu Boundaries, 1871-1889.

Master of ArtsCenter for Japanese StudiesUniversity of Michiganhttps://deepblue.lib.umich.edu/bitstream/2027.42/145104/1/cjsmat_061.pdf45