Relationship between Quality of Life for Patients with Neuroendocrine Tumors and Novel Biomarkers

Research in the field of neuroendocrine tumors (NETs) has increased over the last decade, including studies focused on biochemical markers (biomarkers) of the disease. There is also growing interest in how NETs impact patients\u27 quality of life (QOL). Consequently, there is a paucity of information about whether the expression of the specific disease biomarkers affects QOL as well as whether the primary tumor site impacts QOL. Using the explanatory model of health promotion and quality of life in chronic disabling conditions as the theoretical framework and data collected with the Norfolk QOL-NET instrument, this study\u27s purpose was to fill that gap in knowledge through research questions addressing the relationship between the primary tumor site and NET patients\u27 total QOL score as well as the effect of specific NET biomarkers on NET patients\u27 total QOL score. Data were analyzed using descriptive statistics, one-way analysis of variance (ANOVA), regression analysis, and post hoc tests to determine significance. Results from an ANOVA showed that abnormal NET biomarkers affected total QOL (p = 0.011). In the analyses of whether the independent biomarker variables affected the dependent total QOL variable, only the result for Serotonin Normal was significant (p = 0.002). The presence of abnormal biomarker measurements also affected two of the Norfolk QOL-NET domains significantly, gastrointestinal and physical functioning (p = 0.005 and p = 0.030, respectively). By understanding the relationship between NETs and patient QOL, the potential positive social change implications are helping NET patients assess the severity of their condition, determining what affects their well-being, and using this information to help monitor their treatment/progress

Experimental study of seismic scattering by a penny-shaped crack

Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Earth and Planetary Sciences, 1979.Bibliography: leaves 146-150.by James Francis Scheimer.Ph.D

Ensino de história e estudos culturais

This article aims to analyze the actual presence of Cultural Studies in history teaching in order to lead to a reflection on pedagogical able to ensure the principle that founds and justifies school education as a social institution. Being the school the place where education is for life where they form new generations for the exercise of total citizenship, this study contributes significantly to make it a place of discovery and meaning, a synonym for the new, where the educator awakens in the students what they already know contributing to the formation of conscious citizens who have the understanding of their daily lives, subjects of history providing opportunities for the recovery of its history. The presence of Cultural Studies for educational practice has become something relevant, a form of reconciliation and engagement with the different. The application of cultural studies in the classroom would help students, in a more dynamic way, to reorder and restructure information and experiences leading the student to learn to think through the knowledge related to culture and also to discover imposed speeches about the other.Este artigo tem por objetivo analisar a real presença dos Estudos Culturais no ensino de história, com a finalidade de levar a reflexão sobre uma proposta pedagógica capaz de garantir o princípio, que funda e justifica a educação escolar como instituição social. Sendo a escola o lugar onde se educa para a vida, onde se formam as novas gerações para o exercício da plena cidadania, esse estudo vem contribuir significativamente para torná-la um lugar de descoberta e de significado, sinônimo de novo, onde o educador desperte no aluno o que ele já sabe, contribuindo para a formação de cidadãos conscientes e que tenham compreensão de seu cotidiano, sujeitos da história, oportunizando o resgate de sua história. A presença dos Estudos Culturais à prática educativa tornou-se algo relevante, uma forma de aproximação e de envolvimento com o diferente. A aplicação desses Estudos Culturais na sala de aula ajudaria os alunos, de forma mais dinâmica, a reordenar e a reestruturar essas informações e experiências, levando assim o aluno a aprender a pensar por meio dos conhecimentos relacionados com a cultura, além de descobrir discursos impostos como verdades sobre o outro. Palavras-chave: currículo; Estudos Culturais; educação; História.  The teaching of History and Cultural StudiesAbstract: This article aims to analyze the actual presence of Cultural Studies in history teaching in order to lead to a reflection on pedagogical able to ensure the principle that founds and justifies school education as a social institution. Being the school the place where education is for life where they form new generations for the exercise of total citizenship, this study contributes significantly to make it a place of discovery and meaning, a synonym for the new, where the educator awakens in the students what they already know contributing to the formation of conscious citizens who have the understanding of their daily lives, subjects of history providing opportunities for the recovery of its history. The presence of Cultural Studies for educational practice has become something relevant, a form of reconciliation and engagement with the different. The application of cultural studies in the classroom would help students, in a more dynamic way, to reorder and restructure information and experiences leading the student to learn to think through the knowledge related to culture and also to discover imposed speeches about the other.Keywords: Curriculum, Cultural Studies, Education, History

Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit

The NIH Virtual SARS-CoV-2 Antiviral Summit, held on 6 November 2020, was organized to provide an overview on the status and challenges in developing antiviral therapeutics for coronavirus disease 2019 (COVID-19), including combinations of antivirals. Scientific experts from the public and private sectors convened virtually during a live videocast to discuss severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets for drug discovery as well as the preclinical tools needed to develop and evaluate effective small-molecule antivirals. The goals of the Summit were to review the current state of the science, identify unmet research needs, share insights and lessons learned from treating other infectious diseases, identify opportunities for public-private partnerships, and assist the research community in designing and developing antiviral therapeutics. This report includes an overview of therapeutic approaches, individual panel summaries, and a summary of the discussions and perspectives on the challenges ahead for antiviral development

Photoacoustic stress

The theory for photoacoustic-induced stress in condensed media is developed both for near-field and far-field conditions