Las epistemologías críticas en la producción de conocimiento en Ciencia Política. Un estudio desde las trayectorias de docentes-investigadores de instituciones públicas

El presente proyecto pretendió aportar al estudio del desarrollo de la Ciencia Política en Argentina en el marco de la discusión iniciada por Giovanni Sartori, quien en el año 2004 cuestionó el status epistemológico- metodológico de la disciplina, dando inicio a una fructífera reflexión en torno a sus enfoques y paradigmas. En este marco, se sistematizaron y analizaron procesos de investigación concretos que, dentro del campo disciplinar, abrevan en diversas perspectivas epistemológicas críticas. Esto se llevó adelante a través de una serie de ejes de indagación orientados a analizar dichos procesos de modo transversal: 1- el reconocimiento de la posición del sujeto cognoscente como parte de la situación de investigación, 2- las articulaciones con sujetos y saberes extra-académicos en el proceso de construcción de conocimiento, 3- los vínculos con los espacios institucionales en los que se insertan las investigaciones y 4- las prácticas investigativas, académicas y pedagógicas concretas puestas en marcha en la producción de conocimiento. Estos ejes fueron abordados desde un enfoque cualitativo que combina el análisis documental de publicaciones científicas, con el análisis de trayectorias individuales y colectivas a través de entrevistas semiestructuradas a docentes investigadores de instituciones públicas.    ARK: http://id.caicyt.gov.ar/ark:/s22504559/n86d607b

Scaling and asymptotic laws in subrecoil laser cooling

We derive and analyze scaling properties of the kinetic equation for subrecoil laser cooling. These scaling laws determine the universal asymptotic time behaviour in complete agreement with the results of the statistical analysis in terms of Lévy flights

Highly resolved analysis of the chemistry and mechanical properties of an a-C:H coating system by nanoindentation and auger electron spectroscopy

The small-angle cross-section method was applied to a multi-layered hydrogenated amorphous carbon coating (a-C:H) system deposited by plasma enhanced chemical vapour deposition. The investigated system consists of a silicon rich adhesion layer and an adjacent ramp layer with a graded chemical composition to the a-C:H coating. The mechanical properties and the corresponding chemical gradients of the coating system were analysed by a combination of the small-angle cross-section method together with auger electron spectroscopy and nanoindentation. Furthermore, energy filtered transmission electron microscopy on a thin lamella was used to check the reliability of the auger electron spectroscopy results. It was found that local gradients in the chemical composition within the coating relate well to gradients observed in the local mechanical properties. The used combination of the different methods enables to resolve the correlation between the microstructure, chemical composition and mechanical properties of thin film systems with high spatial resolution

Selective binding and lateral clustering of α5β1 and αvβ3 integrins: Unraveling the spatial requirements for cell spreading and focal adhesion assembly

Coordination of the specific functions of α5β1 and αvβ3 integrins is crucial for the precise regulation of cell adhesion, spreading and migration, yet the contribution of differential integrin-specific crosstalk to these processes remains unclear. To determine the specific functions of αvβ3 and α5β1 integrins, we used nanoarrays of gold particles presenting immobilized, integrin-selective peptidomimetic ligands. Integrin binding to the peptidomimetics is highly selective, and cells can spread on both ligands. However, spreading is faster and the projected cell area is greater on α5β1 ligand; both depend on ligand spacing. Quantitative analysis of adhesion plaques shows that focal adhesion size is increased in cells adhering to αvβ3 ligand at 30 and 60 nm spacings. Analysis of αvβ3 and α5β1 integrin clusters indicates that fibrillar adhesions are more prominent in cells adhering to α5β1 ligand, while clusters are mostly localized at the cell margins in cells adhering to αvβ3 ligand. αvβ3 integrin clusters are more pronounced on αvβ3 ligand, though they can also be detected in cells adhering to α5β1 ligand. Furthermore, α5β1 integrin clusters are present in cells adhering to α5β1 ligand, and often colocalize with αvβ3 clusters. Taken together, these findings indicate that the activation of αvβ3 integrin by ligand binding is dispensable for initial adhesion and spreading, but essential to formation of stable focal adhesions