Calculation of the separation streamlines of barchans and transverse dunes

We use FLUENT to calculate the wind profile over barchans and transverse dunes. The form of the streamlines of flow separation at the lee side of the dunes is determined for a symmetric barchan dune in three dimensions, and for the height profile of a measured transverse dune field in the Len\c{c}\'ois Maranhenses.Comment: 6 pages including 5 figures. Proceedings of PSIS 200

Cosmic-Ray Events as Background in Imaging Atmospheric Cherenkov Telescopes

The dominant background for observations of gamma-rays in the energy region above 50 GeV with Imaging Atmospheric Cherenkov telescopes are cosmic-ray events. The images of most of the cosmic ray showers look significantly different from those of gamma-rays and are therefore easily discriminated. However, a small fraction of events seems to be indistinguishable from gamma-rays. This constitutes an irreducible background to the observation of high-energy gamma-ray sources, and limits the sensitivity achievable with a given instrument. Here, a Monte Carlo study of gamma-like cosmic-ray events is presented. The nature of gamma-like cosmic-ray events, the shower particles that are responsible for the gamma-like appearance, and the dependence of these results on the choice of the hadronic interaction model are investigated. Most of the gamma-like cosmic ray events are characterised by the production of high-energy pi0's early in the shower development which dump most of the shower energy into electromagnetic sub-showers. Also Cherenkov light from single muons can mimic gamma-rays in close-by pairs of telescopes. Differences of up to 25% in the collection area for gamma-like proton showers between QGSJet/FLUKA and Sibyll/FLUKA simulations have been found.Comment: Accepted by Journal of Astroparticle Physic

Ab-initio study of the relation between electric polarization and electric field gradients in ferroelectrics

The hyperfine interaction between the quadrupole moment of atomic nuclei and the electric field gradient (EFG) provides information on the electronic charge distribution close to a given atomic site. In ferroelectric materials, the loss of inversion symmetry of the electronic charge distribution is necessary for the appearance of the electric polarization. We present first-principles density functional theory calculations of ferroelectrics such as BaTiO3, KNbO3, PbTiO3 and other oxides with perovskite structures, by focusing on both EFG tensors and polarization. We analyze the EFG tensor properties such as orientation and correlation between components and their link with electric polarization. This work supports previous studies of ferroelectric materials where a relation between EFG tensors and polarization was observed, which may be exploited to study ferroelectric order when standard techniques to measure polarization are not easily applied.Comment: 9 pages, 6 figures, 5 tables, corrected typos, as published in Phys. Rev.

The Activation-induced Deaminase Functions in a Postcleavage Step of the Somatic Hypermutation Process

Activation of B cells by antigen fuels two distinct molecular modifications of immunoglobulin (Ig) genes. Class-switch recombination (CSR) replaces the Igμ heavy chain constant region with a downstream constant region gene, thereby altering the effector function of the resulting antibodies. Somatic hypermutation (SHM) introduces point mutations into the variable regions of Ig genes, thereby changing the affinity of antibody for antigen. Mechanistic overlap between the two reactions has been suggested by the finding that both require the activation-induced cytidine deaminase (AID). It has been proposed that AID initiates both CSR and SHM by activating a common nuclease. Here we provide evidence that cells lacking AID, or expressing a dominant negative form of the protein, are still able to incur DNA lesions in SHM target sequences. The results indicate that an intact cytidine deaminase motif is required for AID function, and that AID acts downstream of the initial DNA lesions in SHM