Acoustical properties of materials and muffler configurations for the 80 by 120 foot wind tunnel

Techniques for measuring the impedance of the muffler configurations and of porous plates with grazing flow were investigated and changes in the configuration parameters to enhance acoustic performance are explored. The feasibility of a pulse reflection technique for measuring the impedance of built-up structures in situ was demonstrated. A second technique involving the use of an open-end impedance tube with grazing flow was used to obtain detailed design data for the perforated plate configuration. Acoustic benefits associated with configuration changes such as curving the baffles, spacing and staggering baffle partitions, and techniques for alleviating baffle self-generated noise are described

Acoustic transmission through a fuselage sidewall

A definition is given of an idealized fuselage sidewall structure and a simplified analytical model for determining acoustical transmission from the exterior to the interior of a fuselage was constructed. The representation of the sidewall structure chosen for the analytical model excludes complicating effects such as cabin pressurization, acoustic transmission through windows or door seal leaks, aerodynamic excitation, and structural vibration excitation of the fuselage skin

Evaluation of the NASA Ames no. 1 7 by 10 foot wind tunnel as an acoustic test facility

Measurements were made in the no. 1 7'x10' wind tunnel at NASA Ames Research Center, with the objectives of defining the acoustic characteristics and recommending minimum cost treatments so that the tunnel can be converted into an acoustic research facility. The results indicate that the noise levels in the test section are due to (a) noise generation in the test section, associated with the presence of solid bodies such as the pitot tube, and (b) propagation of acoustic energy from the fan. A criterion for noise levels in the test section is recommended, based on low-noise microphone support systems. Noise control methods required to meet the criterion include removal of hardware items for the test section and diffuser, improved design of microphone supports, and installation of acoustic treatment in the settling chamber and diffuser

Shock transmission in coupled beams and rib stiffened structures

Shock transmission in a simple coupled beam structure and in a ring-stringer stiffened cylinder is investigated experimentally and analytically using wave transmission and statistical energy analysis concepts. The use of the response spectrum to characterize the excitation provided to a simple beam by a force pulse is studied. Analysis of the transmission of a dilatation wave in a periodically stiffened plate indicates that the stiffeners are fairly transparent to the wave, but some of the dilatational energy is scattered into bending at each support

Techniques for improving the low-frequency performance of small reverberation chambers

Small reverberation chamber low frequency performance characteristic

A study of noise source location on a model scale augmentor wing using correlation techniques

An experimental investigation, conducted on a model-scale augmentor wing to identify the sources of far-field noise, is examined. The measurement procedure followed in the investigation involved the cross-correlation of far field sound pressures with fluctuating pressures on the surface of the augmentor flap and shroud. In addition pressures on the surfaces of the augmentor were cross-correlated. The results are interpreted as showing that the surface pressure fluctuations are mainly aerodynamic in character and are convected in the downstream direction with a velocity which is dependent on the jet exhaust velocity. However the far field sound levels in the mid and high frequency ranges are dominated by jet noise. There is an indication that in the low frequency range trailing edge noise, associated with interaction of the jet flow and the flap trailing edge, plays a significant role in the radiated sound field

The relationship between the surface pressure spectrum and transverse velocity spectrum in a Rapid-distortion theory model of trailing edge noise

Accurate jet-surface interaction noise prediction remains an important aspect of the aircraft design process. This is particularly true for the next generation aircraft configurations, one of which could see the exhaust system tightly integrated to the airframe. Use of Rapid- distortion theory of turbulence (RDT) to determine the radiated sound represents one such approach to model the sound generation/propagation process. Recent work on the application of RDT to the canonical problem of a jet flow interacting with a flat plate trailing edge gave accurate predictions across the frequency and acoustic Mach number range. In this paper we ascertain whether an RDT based model that uses the unsteady surface pressure spectrum as the source term can also be utilized to determine accurate edge noise predictions. Surface pressure based models have been widely used in the Amiet formulation of trailing edge noise. The upstream boundary condition in the RDT formulation enters via a streamwise convected quantity, ω ̃c(τ − y1/U(yT ), yT ), that is an arbitrary function of its arguments. But since the pressure fluctuation possesses an upstream asymptote that decays algebraically faster than curl of the out-of-plane vorticity fluctuation in the local hydrodynamic relation given by Eq. 3.9 in Goldstein, Leib & Afsar (J. Fluid Mech., vol. 824, pp. 477-512, 2017), this latter relation cannot be used to determine the surface pressure near the trailing edge. In this paper we show to obtain this relation using an inversion of Fourier transforms similar to that used in our earlier paper Goldstein, Afsar & Leib (J. Fluid Mech., vol. 736, pp. 532-569, 2013). The relation we obtain shows how the surface pressure spectrum can therefore be related to the velocity fluctuation correlation function

Coherence and phase techniques applied to noise diagnosis in the NASA Ames 7 times 10-foot wind tunnel no. 1

Measurements have been made of coherence and phase spectra for the acoustic field in a subsonic wind tunnel. The data are interpreted in terms of simple analytical models for propagating and diffuse noise fields, including the presence of uncorrelated noise signals. It is found that low frequency noise propagates upstream and downstream from the fan, with the noise in the test section arriving in the upstream direction. High frequency sound is generated in the test section and propagates upstream and downstream. In the low frequency range, the ratio of diffuse to propagating energy is about eight for all locations in the test section, diffuser, and settling chamber; the value of the ratio increases with frequency

Immune Modulation by Adjuvants Combined with Diphtheria Toxoid Administered Topically in BALB/c Mice After Microneedle Array Pretreatment

Purpose. In this study, modulation of the immune response against diphtheria toxoid (DT) by various adjuvants in transcutaneous immunization (TCI) with microneedle array pretreatment was investigated. Methods. TCI was performed on BALB/c mice with or without microneedle array pretreatment using DT as a model antigen co-administrated with lipopolysaccharide (LPS), Quil A, CpG oligo deoxynucleotide (CpG) or cholera toxin (CT) as adjuvant. The immunogenicity was evaluated by measuring serum IgG subtype titers and neutralizing antibody titers. Results. TCI with microneedle array pretreatment resulted in a 1,000-fold increase of DT-specific serum IgG levels as compared to TCI. The immune response was further improved by co-administration of adjuvants, showing a progressive increase in serum IgG titers when adjuvanted with LPS, Quil A, CpG and CT. IgG titers of the CT-adjuvanted group reached levels comparable to those obtained after DTalum subcutaneous injection. The IgG1/IgG2a ratio of DT-specific antibodies decreased in the following sequence: plain DT, Quil A, CT and CpG, suggesting that the immune response was skewed towards the Th1 direction. Conclusions. The potency and the quality of the immune response against DT administered by microneedle array mediated TCI can be modulated by co-administration of adjuvants. KEY WORDS: cholera toxin; CpG; diphtheria toxoid; microneedle array; transcutaneous immunization

Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development

Interferon regulatory factor (IRF) 8 and IRF4 are structurally-related, hematopoietic cell-specific transcription factors that cooperatively regulate the differentiation of dendritic cells and B cells. Whilst in myeloid cells IRF8 is known to modulate growth and differentiation, the role of IRF4 is poorly understood. In this study, we show that IRF4 has activities similar to IRF8 in regulating myeloid cell development. The ectopic expression of IRF4 in myeloid progenitor cells in vitro inhibits cell growth, promotes macrophages, but hinders granulocytic cell differentiation. We also show that IRF4 binds to and activates transcription through the IRF-Ets composite sequence (IECS). Furthermore, we demonstrate that Irf8-/-Irf4-/- mice exhibit a more severe chronic myeloid leukemia (CML)-like disease than Irf8-/- mice, involving a disproportionate expansion of granulocytes at the expense of monocytes/macrophages. Irf4-/- mice, however, display no obvious abnormality in myeloid cell development, presumably because IRF4 is expressed at a much lower level than IRF8 in granulocyte-macrophage progenitors. Our results also suggest that IRF8 and IRF4 have not only common but also specific activities in myeloid cells. Since the expression of both the IRF8 and IRF4 genes is downregulated in CML patients, these results may add to our understanding of CML pathogenesis