Testamente Bamberger Frauen des 16. und 17. Jahrhunderts

Testamente werden in der historischen Forschung bereits seit geraumer Zeit als wichtige Quellen für die Geschichte der sozialen Beziehungen, der materiellen Kultur, der Frömmigkeitspraktiken und der Einstellungen zum Tod betrachtet. Der vorliegende Band untersucht erstmals systematisch ein Korpus von 84 archivalisch überlieferten Testamenten, die Bamberger Frauen zwischen 1510 und 1700 diktierten. Die Erblasserinnen kamen aus unterschiedlichen sozialen Milieus – das Spektrum umfasst Adelige, Beamtenwitwen, Handwerkerfrauen und Klerikermägde –, und ihre letztwilligen Verfügungen gewähren aufschlussreiche Einblicke in Lebenssituationen, persönliche Erfahrungen und soziale Netzwerke in einer frühneuzeitlichen Bischofsstadt.Historical researchers have long realized the value of wills as sources for the history of social relations, material culture, practices of piety and attitudes towards death. The present volume provides the first systematic analysis of 84 archival wills which women in Bamberg dictated between 1510 and 1700. The testators came from different social strata – including noblewomen, widows of public officials, artisans‘ wives and maids of clergymen – and their last wills provide revealing insights into life situations, personal experiences and social networks in an early modern cathedral town

Swiss experience of atezolizumab for platinum-pretreated urinary tract carcinoma: the SAUL study in real-world practice.

AIMS OF THE STUDY Atezolizumab is an approved therapy for urothelial carcinoma based on results from the IMvigor 210 and IMvigor211 phase II and III trials. The global SAUL study evaluated atezolizumab in a broader patient population more representative of real-world populations. Among approximately 1000 patients treated in SAUL, 25 were treated in Swiss oncology centres. We evaluated outcomes in these patients to provide a better understanding of atezolizumab treatment for urinary tract carcinoma in Swiss clinical practice. METHODS Eligible patients had locally advanced or metastatic urothelial or non-urothelial urinary tract carcinoma that had progressed during or after one to three prior therapies for inoperable, locally advanced or metastatic disease. Patient populations typically excluded from clinical trials (e.g., patients with renal impairment, treated central nervous system [CNS] metastases, stable controlled autoimmune disease or Eastern Cooperative Oncology Group performance status 2) were also eligible. All patients received atezolizumab 1200 mg every 3 weeks until loss of clinical benefit or unacceptable toxicity. The primary endpoint was safety. Secondary endpoints included overall survival (OS), overall response rate (ORR) and disease control rate (DCR). RESULTS All 25 Swiss patients had previously received a gemcitabine/platinum doublet. Disease had progressed within 12 months of platinum-based therapy in all but one patient, and 19 (76%) had received one prior line of therapy for metastatic disease. The median duration of atezolizumab therapy was six cycles (range 1–27) corresponding to 3.6 months. Five patients (20%) had received >20 cycles and four (16%) remained on treatment at the data cut-off. Grade 3 adverse events (AEs) occurred in 13 patients (52%) and were considered to be treatment-related in four patients (16%; liver enzyme increases, musculoskeletal pain, diverticulitis and autoimmune hepatitis). There was one grade 4 AE (hypercalcaemia) and no grade 5 AEs. After median follow-up of 17.3 months, median OS was 7.9 months (95% confidence interval [CI] 5.3–not evaluable), the 1-year OS rate was 47% (95% CI 27–65%), the ORR was 12% (95% CI 3–31%) and the DCR was 40% (95% CI 21–61%). Durable clinical benefit (>1 year on treatment) was observed in seven patients (28%), including one with CNS metastases and one with small-cell carcinoma. CONCLUSIONS Atezolizumab is an active treatment option for platinum-pretreated urinary tract carcinoma, including patients with conditions that typically exclude them from clinical trials. (Trial registration no.: NCT02928406)

Mineralogical and Geochemical Characterization of the Sta. Cruz Nickel Laterite Deposit, Zambales, Philippines

In this study, we present mineralogical and geochemical characterization of samples sys-tematically collected from a nickel laterite profile at the Sta. Cruz nickel laterite deposit, Zambales, Philippines. Wavelength-dispersive X-ray fluorescence spectroscopy (WDSXRF), mass-balance element mobility calculations, transmitted and reflected light microscopy, and previously reported results from coupled X-ray diffraction (XRD) and Rietveld refinement analyses reveal that the laterite profile investigated is composed of two main horizons—the limonite and saprolite zones—separated by a thin transitional zone. Based primarily on the mineral assemblage and major element chemistry, the main zones are further subdivided into subzones: upper limonite, lower limonite, transitional zone, upper saprolite, and lower saprolite. Garnierite veins were observed cutting the upper and lower saprolite subzones. Investigation of the structure of goethite within the limonite zone via Rietveld refinement shows that the crystallinity of goethite decreases with increasing Ni content and increasing crystallite size. This suggests that upwards through the limonite zone, as goethite ages, its crystallinity increases, which possibly results in the removal of Ni from its crystal structure and eventual remobilization to the lower laterite zones

Clock synchronization for a multidevice data acquisition system of a ground penetrating radar

As part of the climate research, controlled environment facilities are deepening the knowledge of highly heterogeneous dynamic ecosystems centered around plants.In the context of climate change, it becomes even more important to study the impact of climate conditions on crops under realistic conditions using large scale laboratories.We develop a high resolution multi-channel ground penetrating radar (GPR) for a cylindrical lysimeter that is 1 m wide and 1.5 m tall. The GPR data is used to reconstruct a tomographic image of the soil and root system.The GPR design, production and commissioning is performed by the Central Institute of Engineering, Electronics and Analytics - Electronic Systems (ZEA-2) of the Forschungszentrum Juelich in Germany.The system is designed with 39 data acquisition (DAQ) units, one unit controls 64 radio frequency antennas and internally called the Baseboard (BAB), and a Master Module (MAM) used to concentrate the data and control the BABs.Prerequisite for a precise tomogram is an accurate synchronization of all data acquisition components and low-jitter clocking.Each BAB is equipped with the necessary clocking distribution, a Xilinx RFSoC providing the DAC and ADCs, and a separate antenna multiplexing FPGA.The layout of the lysimeter is such that the MAM is connected to 13 BABs arranged in a ring on the lowest layer, and each of these is connected to two additional BABs surrounding higher layers of the lysimeter.This combination of a star and chain topography provides a challenge for the clock synchronization and is discussed in this talk.The analysis of the first verification data is shown and the DAQ roadmap is outlined