Prenatal cortisol, prematurity and low birthweight

Three hundred depressed pregnant women were recruited at approximately 20 weeks gestation. They were then divided by a median split into high and low urinary cortisol level groups. The high cortisol group had higher CES-D depression scores and higher inhibition (BIS) scores prenatally. Their fetuses had smaller head circumference, abdominal circumference, biparietal diameter and fetal weight. The high cortisol group neonates were shorter gestational age and lower birthweight and they had lower Brazelton habituation and higher Brazelton reflex scores. Discriminant function analyses suggested that cortisol levels more accurately classified short gestation and low birthweight groups than CES-D depression scores.National Center for Complementary and Alternative Medicine (NCCAM) - (#AT01585).National Institute of Mental Health (NIMH), Senior Scientist Award - (MH #00331), (MH #46586).March of Dimes - Grant (#12-FY03-48)

Sleep disturbances in depressed pregnant women and their newborns

Pregnant women (N= 253) were recruited during their second trimester of pregnancy (M= 22.3 weeks gestation) and assigned to depressed (N= 83) and non-depressed groups based on a SCID diagnosis of depression. They were then given self-report measures on sleep disturbance, depression, anxiety and anger, and their urine was assayed for norepinephrine and cortisol. These measures were repeated during their third trimester (M= 32.4 weeks). Their newborns were then observed during sleep. During both the second and third trimesters, the depressed women had more sleep disturbances and higher depression, anxiety and anger scores. They also had higher norepinephrine and cortisol levels. The newborns of the depressed mothers also had more sleep disturbances including less time in deep sleep and more time in indeterminate (disorganized) sleep, and they were more active and cried/fussed more.We would like to thank the parents and infants who participated in this study. This Research was supported by a merit award (MH# 46586) and Senior Research Scientist Awards (MH# 00331 and AT# 001585) and a March of Dimes Grant (#12-FYO3-48) to Tiffany Field and funding from Johnson & Johnson Pediatric Institute to the Touch Research Institutes

Chronic prenatal depression and neonatal outcome

Four hundred and thirty pregnant women were recruited at approximately 22 weeks gestation at prenatal clinics. Of these, 86 (20%) were diagnosed as depressed. The women were seen again at approximately 32 weeks gestation and after delivery. Chronicity of depression was evidenced by continuing high depression scores in those women diagnosed as depressed. Comorbid problems were chronically high anxiety, anger, sleep disturbance, and pain scores. Less optimal outcomes for the depressed women included lower gestational age and lower birthweight of their newborns

Prenatal dopamine and neonatal behavior and biochemistry

Depressed pregnant women (N=126) were divided into high and low prenatal maternal dopamine (HVA) groups based on a tertile split on their dopamine levels at 20 weeks gestation. The high versus the low dopamine group had lower Center for Epidemiological Studies-Depression Scale (CES-D) scores, higher norepinephrine levels at the 20-week gestational age visit and higher dopamine and serotonin levels at both the 20- and the 32-week gestational age visits. The neonates of the mothers with high versus low prenatal dopamine levels also had higher dopamine and serotonin levels as well as lower cortisol levels. Finally, the neonates in the high dopamine group had better autonomic stability and excitability scores on the Brazelton Neonatal Behavior Assessment Scale. Thus, prenatal maternal dopamine levels appear to be negatively related to prenatal depression scores and positively related to neonatal dopamine and behavioral regulation, although these effects are confounded by elevated serotonin levels.We would like to thank the mothers and infants who participated in this study. This research was supported by a Merit Award (MH#46586) and NIH grant (AT#00370) and Senior Research Scientist Awards(MH#00331 and AT#001585) and a March of Dimes Grant (#12-FYO3-48)to Tiffany Field and funding from Johnson and Johnson Pediatric Institute to the Touch Research Institute

Prenatal serotonin and neonatal outcome: brief report

The purpose of the present study was to determine the relationships between prenatal serotonin levels and other biochemical values during pregnancy as well as their relationships to neonatal biochemical and behavioral variables. To address that question, the pregnant women were divided into the top and bottom tertiles based on their serotonin levels at 20 weeks gestational age

Comorbid depression and anxiety effects on pregnancy and neonatal outcome

The effects of comorbid depression and anxiety were compared to the effects of depression alone and anxiety alone on pregnancy mood states and biochemistry and on neonatal outcomes in a large multi-ethnic sample. At the prenatal period the comorbid and depressed groups had higher scores than the other groups on the depression measure. But, the comorbid group had higher anxiety, anger and daily hassles scores than the other groups, and they had lower dopamine levels. As compared to the non-depressed group, they also reported more sleep disturbances and relationship problems. The comorbid group also experienced a greater incidence of prematurity than the depressed, the high anxiety and the non-depressed groups. Although the comorbid and anxiety groups were lower birthweight than the non-depressed and depressed groups, the comorbid group did not differ from the depressed and anxiety groups on birth length. The neonates of the comorbid and depressed groups had higher cortisol and norepinephrine and lower dopamine and serotonin levels than the neonates of the anxiety and non-depressed groups as well as greater relative right frontal EEG. These data suggest that for some measures comorbidity of depression and anxiety is the worst condition (e.g., incidence of prematurity), while for others, comorbidity is no more impactful than depression alone.This research was supported by a Merit Award (MH #46586), an NIH grant (AT #00370) and Senior Research Scientist Awards (MH #0033 1 and AT #001585) and a March of Dimes Grant (#12-FYO3-48) to Tiffany Field and funding from Johnson and Johnson Pediatric Institute to the Touch Research Institute

Alleviating posttraumatic stress in children following hurricane Andrew

Sixty grade-school children who showed classroom behavior problems following Hurricane Andrew were given massage therapy on 8 days 1 month after the hurricane. Scores on the PTSD Reaction Index suggest that the children were experiencing severe posttraumatic stress. As compared to a video attention control group, the children who received massage therapy reported being happier and less anxious and had lower salivary cortisol levels after the therapy. In addition, the massage therapy group showed more sustained changes as manifested by lower scores on the Children's Manifest Anxiety Scale, The Center for Epidemiological Studies Depression Scale, and self-drawings, and were observed to be more relaxed. These positive effects were promising given the persistence of PTSD symptoms noted for children who have not received intervention following disasters such as hurricanes

Massage therapy improves mood and behavior of students with attention-deficit/hyperactivity disorder

In the present study, 30 students between the ages of 7 and 18 years (M = 13 years) diagnosed with attention-deficit/hyperactivity disorder (ADHD) were randomly assigned to a massage group or a wait-list control group. The massage group received massage therapy for 20 minutes twice per week over the course of one month. The results revealed that massage therapy benefited students with ADHD by improving short-term mood state and longer-term classroom behavior