Experiments in a three-dimensional adaptive-wall wind tunnel

Three dimensional adaptive-wall experiments were performed in the Ames Research Center (ARC) 25- by 13-cm indraft wind tunnel. A semispan wing model was mounted to one sidewall of a test section with solid sidewalls, and slotted top and bottom walls. The test section had separate top and bottom plenums which were divided into streamwise and cross-stream compartments. An iterative procedure was demonstrated for measuring wall interference and for adjusting the plenum compartment pressures to eliminate such interference. The experiments were conducted at a freestream Mach number of 0.60 and model angles of attack between 0 and 6 deg. Although in all the experiments wall interference was reduced after the plenum pressures were adjusted, interference could not be completely eliminated

Analysis of turbofan propulsion system weight and dimensions

Weight and dimensional relationships that are used in aircraft preliminary design studies are analyzed. These relationships are relatively simple to prove useful to the preliminary designer, but they are sufficiently detailed to provide meaningful design tradeoffs. All weight and dimensional relationships are developed from data bases of existing and conceptual turbofan engines. The total propulsion system is considered including both engine and nacelle, and all estimating relations stem from physical principles, not statistical correlations

Adaptive-wall wind-tunnel research at NASA-Ames Research Center

Adaptive wall wind tunnel research is summarized. Small scale two and three dimensional wind tunnel experiments and numerical experiments with a three dimensional adaptive wall simulator are included. A NACA 0012 airfoil was tested in a 25 by 13 cm slotted wall test section. Airflow through the test section walls was controlled by adjusting the pressures in segmented plenums. Interference free conditions were successfully attained in subsonic and transonic flows. For the three dimensional experiment, the 25 by 13 cm wind tunnel was modified to permit cross stream wall adjustments. The test model was a semispan wing mounted to one sidewall. Wall interference was substantially reduced at several angles of attack at Mach 0.60. A wing on wall configuration was also modeled in the numerical experiments. These flow simulations showed that free air conditions can be approximated by adjusting boundary conditions at only the floor and ceiling of the test section. No sidewall control was necessary. Typical results from these experiments are discussed

Methods for assessing wall interference in the 2- by 2-foot adaptive-wall wind tunnel

Discussed are two methods for assessing two-dimensional wall interference in the adaptive-wall test section of the NASA Ames 2 x 2-Foot Transonic Wind Tunnel: (1) a method for predicting free-air conditions near the walls of the test section (adaptive-wall methods); and (2) a method for estimating wall-induced velocities near the model (correction methods), both of which methods are based on measurements of either one or two components of flow velocity near the walls of the test section. Each method is demonstrated using simulated wind tunnel data and is compared with other methods of the same type. The two-component adaptive-wall and correction methods were found to be preferable to the corresponding one-component methods because: (1) they are more sensitive to, and give a more complete description of, wall interference; (2) they require measurements at fewer locations; (3) they can be used to establish free-stream conditions; and (4) they are independent of a description of the model and constants of integration

Effects of upper surface modification on the aerodynamic characteristics of the NACA 63 sub 2-215 airfoil section

An upper surface modification designed to increase the maximum lift coefficient of a 63 sub 2 - 215 airfoil section was tested at Mach numbers of 0.2, 0.3, and 0.4 Reynolds numbers of 1.3 x 1 million, 2 x 10 sub 6 and 2.5 x 1 million. Comparisons of the aerodynamic coefficients before and after the modification were made. The upper surface modification increased the maximum lift coefficient of the airfoil significantly at all conditions

Suicide in cancer patients in South East England from 1996 to 2005: a population-based study

BACKGROUND: Studies from around the world have shown that suicide risk is increased in cancer patients, but no previous detailed analysis has been carried out in England

Use of aspirin, other nonsteroidal anti-inflammatory drugs and acetaminophen and risk of endometrial cancer : the Epidemiology of Endometrial Cancer Consortium

Background: Regular use of aspirin has been associated with a reduced risk of cancer at several sites but the data for endometrial cancer are conflicting. Evidence regarding use of other analgesics is limited. Patients and methods: We pooled individual-level data from seven cohort and five case-control studies participating in the Epidemiology of Endometrial Cancer Consortium including 7120 women with endometrial cancer and 16 069 controls. For overall analyses, study-specific odds ratios (ORs) and 95% confidence intervals (CI) were estimated using logistic regression and combined using random-effects meta-analysis; for stratified analyses, we used mixed-effects logistic regression with study as a random effect. Results: At least weekly use of aspirin and non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) was associated with an approximately 15% reduced risk of endometrial cancer among both overweight and obese women (OR 1/4 0.86 [95% CI 0.760.98] and 0.86 [95% CI 0.76-0.97], respectively, for aspirin; 0.87 [95% CI 0.76-1.00] and 0.84 [0.74-0.96], respectively, for nonaspirin NSAIDs). There was no association among women of normal weight (body mass index<25 kg/ m2, Pheterogeneity 0.04 for aspirin, Pheterogeneity 1/4 0.003 for NSAIDs). Among overweight and obese women, the inverse association with aspirin was stronger for use 2-6 times/ week (OR 1/4 0.81, 95% CI 0.68-0.96) than for daily use (0.91, 0.80-1.03), possibly because a high proportion of daily users use low-dose formulations. There was no clear association with use of acetaminophen. Conclusion: Our pooled analysis provides further evidence that use of standard-dose aspirin or other NSAIDs may reduce risk of endometrial cancer among overweight and obese women.Peer reviewe

Steroid hormone measurements from different types of assays in relation to body mass index and breast cancer risk in postmenopausal women: Reanalysis of eighteen prospective studies

Epidemiological studies have examined breast cancer risk in relation to sex hormone concentrations measured by different methods: "extraction" immunoassays (with prior purification by organic solvent extraction, with or without column chromatography), "direct" immunoassays (no prior extraction or column chromatography), and more recently with mass spectrometry-based assays. We describe the associations of estradiol, estrone and testosterone with both body mass index and breast cancer risk in postmenopausal women according to assay method, using data from a collaborative pooled analysis of 18 prospective studies. In general, hormone concentrations were highest in studies that used direct assays and lowest in studies that used mass spectrometry-based assays. Estradiol and estrone were strongly positively associated with body mass index, regardless of the assay method; testosterone was positively associated with body mass index for direct assays, but less clearly for extraction assays, and there were few data for mass spectrometry assays. The correlations of estradiol with body mass index, estrone and testosterone were lower for direct assays than for extraction and mass spectrometry assays, suggesting that the estimates from the direct assays were less precise. For breast cancer risk, all three hormones were strongly positively associated with risk regardless of assay method (except for testosterone by mass spectrometry where there were few data), with no statistically significant differences in the trends, but differences may emerge as new data accumulate. Future epidemiological and clinical research studies should continue to use the most accurate assays that are feasible within the design characteristics of each study