Pressure transducer 3/8-inch in size can be faired into surface

To measure fluid pressure with minimum disturbance to fluid flow, a miniature pressure transducer can be imbedded and faired into the test surface. Incorporated in the design are piezoresistive elements mounted on a diaphragm, which transform pressure strains into an electrical signal

Porphyrias associated with malignant tumors: Results of treatment with ionizing irradiation

Background: Porphyrin metabolism disorders, known as porphyria, represent inherited or acquired diseases. The development of porphyria due to light sensibility occurs especially with exposure to wavelengths in the range of 300-700 nm. Skin reactions and neurovisceral dysfunctions are known side effects of ionizing irradiation. It can be postulated that during or after ionizing irradiation treatment of patients affected with tumor and porphyria, severe side effects might appear, in contrast to patients without porphyria. This paper describes the treatment of 2 patients affected with tumor and concomitant porphyria. Patients: One female patient suffering from intermittent porphyria and breast cancer and one male patient suffering from porphyria cutanea tarda and bladder cancer were treated with ionizing irradiation (electrons and photons). No abnormalities nor any severe general or local side effects could be observed. Conclusion: Radiation therapy is not a `stimulating' factor in activating porphyria symptoms

Radio-chemotherapy as a preoperative treatment for advanced rectal cancer. Evaluation of down-staging and morbidity

Background: The standard therapy for patients with clinically resectable rectal cancer is generally considered to be surgery, If the patient is diagnosed with advanced disease, postoperative radiochemotherapy (RCT) is usually recommended. In our study we aimed to investigate and analyze the effectiveness and toxicity of preoperative pelvic radiotherapy in combination with 5-fluorouracil (5-FU) in locally advanced rectal cancer. Patients and Methods: From June 1999 to September 2001 we evaluated 50 consecutive patients {[}37 male and 13 female; average age 65.1 (range 46-79.5) years] with locally advanced rectal carcinoma. 32 patients were staged as uT3, 14 as uT4, and 4 as uT2. Regarding N-staging, 22 patients were diagnosed as ONO. 2 patients had distant metastases, with liver metastases in both instances. Conformal irradiation was performed with a box technique 4-field technique) with a dose of 45 Gy (5 x 1.8 Gy per week for a total of 25 sessions). From days 1-5 and 29-33, all patients received 5-FU (500 mg/m(2) per day, as a continuous i.v. injection). Results: Remission was observed in 28 patients (56%), with down-staging of at least one T-stage. A better success rate was achieved for patients with deep-seated tumors (64% of the patients in this group). Complete remission was observed in 4 patients (8.0%) and progression in 3 (6.0%). 15 patients had no detectable change in tumor staging (30.0%). A surgical R0 resection could be achieved in 43 patients, an R1 resection (minimal margins in 7. Side effects and toxicity (common toxicity criteria) of RCT included grade I-II dysuria in 5 patients (10%), grade I-II diarrhea in 20 patients (40%), and severe diarrhea in 2 patients (4.0%). Grade I-II skin reaction was noticed in 22 patients (44.0%), severe skin reaction only in 1 patient. Regarding acute postoperative morbidity, abscess and fistula formation was noted in 8 patients (16.0%), with anastomosis leakage in 7 (14%). Conclusion: Preoperative radiotherapy appears to be a feasible therapeutic approach with moderate toxicity and the potential to induce down-staging. The data presented in this study confirm the preliminary reports on this neoadjuvant treatment

Suboccipital lateral injection of intrathecal chemotherapy in a patient with mantle cell lymphoma

Background: Even today patients who suffer from mantle cell lymphoma have a poor prognosis, especially when the CNS is involved. To confirm the diagnosis of meningeosis lymphomatosa, asservation of the liquor cerebrospinalis is necessary. During this procedure, intrathecal chemotherapy may be given if there is clinical evidence of meningeosis. If lumbar puncture cannot be performed, a lateral suboccipital puncture may be an alternative approach. Patient and Methods: We report the case of a 65-year-old patient who suffered from mantle cell lymphoma stage IV. The patient presented with symptoms of progressive paraparesis of both legs and incontinence, with tumor mass intradural from the 12th thoracic vertebra to the level of S1. During irradiation, the patient developed symptoms of diffuse meningiosis lymphomatosa. The conventional lumbar puncture was impossible, because of tumor present in the thoracico-lumbar junction. Results: A suboccipital puncture was performed for both collecting cerebrospinal fluid and application of chemotherapy ( cytosine arabinoside/dexamethasone). This lead to remarkable improvement of the patient's clinical symptoms. Conclusion: The suboccipital cervical puncture was performed without complications. A variation of the intrathecal approach is described, which may serve as alternative when conventional lumbar puncture is not possible

Presidential address at the annual general meeting(M.A.S.A), Pretoria

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Dermatology in general practice

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Acute agranulocytosis

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Short term appointments for British graduates at South African hospitals

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Fast High Resolution Echelle Spectroscopy Of A Laboratory Plasma

An echelle diffraction grating and a multianode photomultiplier tube are paired to construct a high resolution (R=lambda/delta lambda approximate to 2.5x10(4)) spectrograph with fast time response for use from the UV through the visible. This instrument has analyzed the line shape of C III impurity ion emission at 229.687 nm over the lifetime (approximate to 100 mu s) of the hydrogen plasmas produced at SSX. The ion temperature and line of sight average velocity are inferred from the observed thermal broadening and Doppler shift of the line. The time resolution of these measurements is about 1 mu s, sufficient to observe the fastest magnetohydrodynamic activity

International Space Station EXPRESS Pallet. Ground Demonstration Baseline Design Review

This publication is comprised of the viewgraphs from the presentations of the EXPRESS Pallet Baseline Design Review meeting held July 20, 1995. Individual presentations addressed general requirements and objectives; mechanical, electrical, and data systems; software; operations and KSC (Kennedy Space Center) integration; payload candidates; thermal considerations; ground vs. flight demo; and recommended actions