The Parallel Distributed Image Search Engine (ParaDISE)

Image retrieval is a complex task that differs according to the context and the user requirements in any specific field, for example in a medical environment. Search by text is often not possible or optimal and retrieval by the visual content does not always succeed in modelling high-level concepts that a user is looking for. Modern image retrieval techniques consists of multiple steps and aim to retrieve information from large–scale datasets and not only based on global image appearance but local features and if possible in a connection between visual features and text or semantics. This paper presents the Parallel Distributed Image Search Engine (ParaDISE), an image retrieval system that combines visual search with text–based retrieval and that is available as open source and free of charge. The main design concepts of ParaDISE are flexibility, expandability, scalability and interoperability. These concepts constitute the system, able to be used both in real–world applications and as an image retrieval research platform. Apart from the architecture and the implementation of the system, two use cases are described, an application of ParaDISE in retrieval of images from the medical literature and a visual feature evaluation for medical image retrieval. Future steps include the creation of an open source community that will contribute and expand this platform based on the existing parts

Overview of the ImageCLEF 2016 Medical Task

ImageCLEF is the image retrieval task of the Conference and Labs of the Evaluation Forum (CLEF). ImageCLEF has historically focused on the multimodal and language–independent retrieval of images. Many tasks are related to image classification and the annotation of image data as well. The medical task has focused more on image retrieval in the beginning and then retrieval and classification tasks in subsequent years. In 2016 a main focus was the creation of meta data for a collection of medical images taken from articles of the the biomedical scientific literature. In total 8 teams participated in the four tasks and 69 runs were submitted. No team participated in the caption prediction task, a totally new task. Deep learning has now been used for several of the ImageCLEF tasks and by many of the participants obtaining very good results. A majority of runs was submitting using deep learning and this follows general trends in machine learning. In several of the tasks multimodal approaches clearly led to best results

Using Crowdsourcing for Multi-label Biomedical Compound Figure Annotation

Information analysis or retrieval for images in the biomedical literature needs to deal with a large amount of compound figures (figures containing several subfigures), as they constitute probably more than half of all images in repositories such as PubMed Central, which was the data set used for the task. The ImageCLEFmed benchmark proposed among other tasks in 2015 and 2016 a multi-label classification task, which aims at evaluating the automatic classification of figures into 30 image types. This task was based on compound figures and thus the figures were distributed to participants as compound figures but also in a separated form. Therefore, the generation of a gold standard was required, so that algorithms of participants can be evaluated and compared. This work presents the process carried out to generate the multi-labels of ∼2650 compound figures using a crowdsourcing approach. Automatic algorithms to separate compound figures into subfigures were used and the results were then validated or corrected via crowdsourcing. The image types (MR, CT, X–ray, ...) were also annotated by crowdsourcing including detailed quality control. Quality control is necessary to insure quality of the annotated data as much as possible. ∼625 h were invested with a cost of ∼870$

Comparing Fusion Techniques for the ImageCLEF 2013 Medical Case Retrieval Task

Retrieval systems can supply similar cases with a proven diagnosis to a new example case under observation to help clinicians during their work. The ImageCLEFmed evaluation campaign proposes a framework where research groups can compare case-based retrieval approaches. This paper focuses on the case-based task and adds results of the compound figure separation and modality classification tasks. Several fusion approaches are compared to identify the approaches best adapted to the heterogeneous data of the task. Fusion of visual and textual features is analyzed, demonstrating that the selection of the fusion strategy can improve the best performance on the case-based retrieval task

The medGIFT Group in ImageCLEFmed 2013

This article presents the participation of the medGIFT groupin ImageCLEFmed 2013. Since 2004, the group has participated in themedical image retrieval tasks of ImageCLEF each year. There are fourtypes of tasks for ImageCLEFmed 2013: modality classi cation, image{based retrieval, case{based retrieval and a new task on compound gureseparation. The medGIFT group participated in all four tasks. MedGIFTis developing a system named ParaDISE (Parallel Distributed ImageSearch Engine), which is the successor of GIFT (GNU Image FindingTool). The alpha version of ParaDISE was used to run the experimentsin the competition. The focus was on the use of multiple features incombinations with novel strategies, i.e, compound gure separation formodality classi cation or modality ltering for ad{hoc image and case{based retrieval

Semi–Supervised Learning for Image Modality Classification

Searching for medical image content is a regular task for many physicians, especially in radiology. Retrieval of medical images from the scientific literature can benefit from automatic modality classification to focus the search and filter out non–relevant items. Training datasets are often unevenly distributed regarding the classes resulting sometimes in a less than optimal classification performance. This article proposes a semi–supervised learning approach applied using a k–Nearest Neighbour (k–NN) classifier to exploit unlabelled data and to expand the training set. The algorithmic implementation is described and the method is evaluated on the ImageCLEFmed modality classification benchmark. Results show that this approach achieves an improved performance over supervised k–NN and Random Forest classifiers. Moreover, medical case–based retrieval benefits from the modality filter

Standardised convolutional filtering for radiomics

The Image Biomarker Standardisation Initiative (IBSI) aims to improve reproducibility of radiomics studies by standardising the computational process of extracting image biomarkers (features) from images. We have previously established reference values for 169 commonly used features, created a standard radiomics image processing scheme, and developed reporting guidelines for radiomic studies. However, several aspects are not standardised. Here we present a preliminary version of a reference manual on the use of convolutional image filters in radiomics. Filters, such as wavelets or Laplacian of Gaussian filters, play an important part in emphasising specific image characteristics such as edges and blobs. Features derived from filter response maps have been found to be poorly reproducible. This reference manual forms the basis of ongoing work on standardising convolutional filters in radiomics, and will be updated as this work progresses.Comment: 62 pages. For additional information see https://theibsi.github.io

Crowdsourcing for Medical Image Classification

To help manage the large amount of biomedical images produced, image information retrieval tools have been developed to help access the right information at the right moment. To provide a test bed for image retrieval evaluation, the ImageCLEFmed benchmark proposes a biomedical classification task that automatically focuses on determining the image modality of figures from biomedical journal articles. In the training data for this machine learning task, some classes have many more images than others and thus a few classes are not well represented, which is a challenge for automatic image classification. To address this problem, an automatic training set expansion was first proposed. To improve the accuracy of the automatic training set expansion, a manual verification of the training set is done using the crowdsourcing platform Crowdflower. This platform allows the use of external persons to pay for the crowdsourcing or to use personal contacts free of charge. Crowdsourcing requires strict quality control or using trusted persons but it can quickly give access to a large number of judges and thus improve many machine learning tasks. Results show that the manual annotation of a large amount of biomedical images carried out in this project can help with image classification

Antibody-induced erythrophagocyte reprogramming of Kupffer cells prevents anti-CD40 cancer immunotherapy-associated liver toxicity

BackgroundAgonistic anti-CD40 monoclonal antibodies (mAbs) have emerged as promising immunotherapeutic compounds with impressive antitumor effects in mouse models. However, preclinical and clinical studies faced dose-limiting toxicities mediated by necroinflammatory liver disease. An effective prophylactic treatment for liver immune-related adverse events that does not suppress specific antitumor immunity remains to be found.MethodsWe used different mouse models and time-resolved single-cell RNA-sequencing to characterize the pathogenesis of anti-CD40 mAb induced liver toxicity. Subsequently, we developed an antibody-based treatment protocol to selectively target red blood cells (RBCs) for erythrophagocytosis in the liver, inducing an anti-inflammatory liver macrophage reprogramming.ResultsWe discovered that CD40 signaling in Clec4f$^{+}$Kupffer cells is the non-redundant trigger of anti-CD40 mAb-induced liver toxicity. Taking advantage of the highly specific functionality of liver macrophages to clear antibody-tagged RBCs from the blood, we hypothesized that controlled erythrophagocytosis and the linked anti-inflammatory signaling by the endogenous metabolite heme could be exploited to reprogram liver macrophages selectively. Repeated low-dose administration of a recombinant murine Ter119 antibody directed RBCs for selective phagocytosis in the liver and skewed the phenotype of liver macrophages into a Hmox$^{high}$/Marco$^{high}$/MHCII$^{low}$anti-inflammatory phenotype. This unique mode of action prevented necroinflammatory liver disease following high-dose administration of anti-CD40 mAbs. In contrast, extrahepatic inflammation, antigen-specific immunity, and antitumor activity remained unaffected in Ter119 treated animals.ConclusionsOur study offers a targeted approach to uncouple CD40-augmented antitumor immunity in peripheral tissues from harmful inflammatoxicity in the liver

The image biomarker standardization initiative: Standardized convolutional filters for reproducible radiomics and enhanced clinical insights

Standardizing convolutional filters that enhance specific structures and patterns in medical imaging enables reproducible radiomics analyses, improving consistency and reliability for enhanced clinical insights. Filters are commonly used to enhance specific structures and patterns in images, such as vessels or peritumoral regions, to enable clinical insights beyond the visible image using radiomics. However, their lack of standardization restricts reproducibility and clinical translation of radiomics decision support tools. In this special report, teams of researchers who developed radiomics software participated in a three-phase study (September 2020 to December 2022) to establish a standardized set of filters. The first two phases focused on finding reference filtered images and reference feature values for commonly used convolutional filters: mean, Laplacian of Gaussian, Laws and Gabor kernels, separable and nonseparable wavelets (including decomposed forms), and Riesz transformations. In the first phase, 15 teams used digital phantoms to establish 33 reference filtered images of 36 filter configurations. In phase 2, 11 teams used a chest CT image to derive reference values for 323 of 396 features computed from filtered images using 22 filter and image processing configurations. Reference filtered images and feature values for Riesz transformations were not established. Reproducibility of standardized convolutional filters was validated on a public data set of multimodal imaging (CT, fluorodeoxyglucose PET, and T1-weighted MRI) in 51 patients with soft-tissue sarcoma. At validation, reproducibility of 486 features computed from filtered images using nine configurations × three imaging modalities was assessed using the lower bounds of 95% CIs of intraclass correlation coefficients. Out of 486 features, 458 were found to be reproducible across nine teams with lower bounds of 95% CIs of intraclass correlation coefficients greater than 0.75. In conclusion, eight filter types were standardized with reference filtered images and reference feature values for verifying and calibrating radiomics software packages. A web-based tool is available for compliance checking