The Argument from Consciousness and Divine Consciousness

The paper aims for an improvement of the so-called argument from consciousness while focusing on the first-person-perspective as a unique feature of consciousness that opens the floor for a theistic explanation. As a side effect of knowledge arguments, which are necessary to keep a posterior materialism off bounds, the paper proposes an interpretation of divine knowledge as knowledge of things rather than knowledge of facts

The Challenge of Theodicy and the Divine Access to the Universe

Any new attempt to cope with the problem of theodicy is forced to reinterpret and remodify the classic set of divine attributes. Classical monotheism, at least in the Christian or Islamic tradition, emphasizes the concept of God as a personal, almighty being who is in a completely free relation to the world. However, even within Christianity we find other tendencies which might help us to rewrite the idea that God has some sort of libertarian and unrestricted access to the world. The following article raises the question whether God, as an absolute being, can influence the course of the world directly. The answer to this question has an enormous impact on the problem of theodicy: If God’s nonintervention is based on God’s essence (rather than any form of initial self-restriction), then God cannot be held directly responsible for not performing direct acts of interventio

Divine Activity

The paper discusses basic models of divine action and intervention. However, the most part of the article is dedicated to the question whether or not there are theistic reasons to stick to some sort of non-interventionism. Therefore, Schleiermacher’s argument is put under scrutiny and presented in a way that could substantiate some version of non-interventionism. Additionally, the paper explores an argument in favor of non-interventionism coming from a specific notion of divine aseity and self-sufficiency. Ultimately the paper votes for a broader notion of the God-world-relationship alluding to the idea of the world being God’s body

Constructing a Religious Worldview: Why Religious Antirealism is Still interesting

After a short overview of anti-realist positions within the philosophy of religion, the following paper argues in favour of a moderate version of religious anti-realism. especially the notions of ”revelation’ and ”religious experience’ seem to suggest that certain dichotomies that are typical for realism cannot be upheld consistently within philosophy of religion. However, the end of the paper shows a different route, which might overcome the realism/antirealism dichotomy as such

Chitosan in non-viral gene delivery: Role of structure, characterization methods, and insights in cancer and rare diseases therapy

Non-viral gene delivery vectors have lagged far behind viral ones in the current pipeline of clinical trials of gene therapy nanomedicines. Even when non-viral nanovectors pose less safety risks than do viruses, their efficacy is much lower. Since the early studies to deliver pDNA, chitosan has been regarded as a highly attractive biopolymer to deliver nucleic acids intracellularly and induce a transgenic response resulting in either upregulation of protein expression (for pDNA, mRNA) or its downregulation (for siRNA or microRNA). This is explained as the consequence of a multi-step process involving condensation of nucleic acids, protection against degradation, stabilization in physiological conditions, cellular internalization, release from the endolysosome (“proton sponge” effect), unpacking and enabling the trafficking of pDNA to the nucleus or the siRNA to the RNA interference silencing complex (RISC). Given the multiple steps and complexity involved in the gene transfection process, there is a dearth of understanding of the role of chitosan’s structural features (Mw and degree of acetylation, DA%) on each step that dictates the net transfection efficiency and its kinetics. The use of fully characterized chitosan samples along with the utilization of complementary biophysical and biological techniques is key to bridging this gap of knowledge and identifying the optimal chitosans for delivering a specific gene. Other aspects such as cell type and administration route are also at play. At the same time, the role of chitosan structural features on the morphology, size and surface composition of synthetic virus-like particles has barely been addressed. The ongoing revolution brought about by the recent discovery of CRISPR-Cas9 technology will undoubtedly be a game changer in this field in the short term. In the field of rare diseases, gene therapy is perhaps where the greatest potential lies and we anticipate that chitosans will be key players in the translation of research to the clinic