Microscopic calculations of double and triple Giant Resonance excitation in heavy ion collisions

We perform microscopic calculations of the inelastic cross sections for the double and triple excitation of giant resonances induced by heavy ion probes within a semicalssical coupled channels formalism. The channels are defined as eigenstates of a bosonic quartic Hamiltonian constructed in terms of collective RPA phonons. Therefore, they are superpositions of several multiphonon states, also with different numbers of phonons and the spectrum is anharmonic. The inclusion of (n+1) phonon configurations affects the states whose main component is a n-phonon one and leads to an appreacible lowering of their energies. We check the effects of such further anharmonicities on the previous published results for the cross section for the double excitation of Giant Resonances. We find that the only effect is a shift of the peaks towards lower energies, the double GR cross section being not modified by the explicity inclusion of the three-phonon channels in the dynamical calculations. The latters give an important contribution to the cross section in the triple GR energy region which however is still smaller than the experimental available data. The inclusion of four phonon configurations in the structure calculations does not modify the results.Comment: Revtex4, to be published in PR

Microscopic description of Coulomb and nuclear excitation of multiphonon states in 40^{40}Ca + 40^{40}Ca collisions

We calculate the inelastic scattering cross sections to populate one- and two-phonon states in heavy ion collisions with both Coulomb and nuclear excitations. Starting from a microscopic approach based on RPA, we go beyond it in order to treat anharmonicities and non-linear terms in the exciting field. These anharmonicities and non-linearities are shown to have important effects on the cross sections both in the low energy part of the spectrum and in the energy region of the Double Giant Quadrupole Resonance. By properly introducing an optical potential the inelastic cross section is calculated semiclassically by integrating the excitation probability over all impact parameters. A satisfactory agreement with the experimental results is obtained.Comment: 20 pages, 2 figures, revtex, to be published in Phys. Rev.

Improvement of resveratrol permeation through sublingual mucosa: Chemical permeation enhancers versus spray drying technique to obtain fast-disintegrating sublingual mini-tablets

Resveratrol (RSV) is a natural polyphenol with several interesting broad-spectrum pharmacological properties. However, it is characterized by poor oral bioavailability, extensive first-pass effect metabolism and low stability. Indeed, RSV could benefit from the advantage of the sublingual route of administration. In this view, RSV attitudes to crossing the porcine sublingual mucosa were evaluated and promoted both by six different chemical permeation enhancers (CPEs) as well as by preparing four innovative fast-disintegrating sublingual mini-tablets by spray drying followed by direct compression. Since RSV by itself exhibits a low permeation aptitude, this could be significantly enhanced by the use of CPEs as well as by embedding RSV in a spray-dried powder to be compressed in order to prepare fast-disintegrating mini-tablets. The most promising observed CPEs (menthol, lysine and urea) were then inserted into the most promising spray-dried excipients’ compositions (RSV-B and RSV-C), thus preparing CPE-loaded mini-tablets. However, this procedure leads to unsatisfactory results which preclude the possibility of merging the two proposed approaches. Finally, the best spray-dried composition (RSV-B) was further evaluated by SEM, FTIR, XRD and disintegration as well as dissolution behavior to prove its effectiveness as a sublingual fast-disintegrating formulation

Anharmonic vibrations in nuclei

In this letter, we show that the non-linearitites of large amplitude motions in atomic nuclei induce giant quadrupole and monopole vibrations. As a consequence, the main source of anharmonicity is the coupling with configurations including one of these two giant resonances on top of any state. Two-phonon energies are often lowered by one or two MeV because of the large matrix elements with such three phonon configurations. These effects are studied in two nuclei, 40Ca and 208Pb

Lipid nanocarriers-loaded nanocomposite as a suitable platform to release antibacterial and antioxidant agents for immediate dental implant placement restorative treatment

Immediate implant placement is a single-stage restorative approach for missing teeth widely used to overcome the ridge remodeling process occurring after dental extractions. The success of this procedure relies on opportune osseointegration in the surrounding tissues. To support this process, a multifunctional nanocomposite, to be applied in the fresh post-extraction socket, was here designed, prepared, and characterized. This formulation consists of quercetin (QRC)-loaded nanostructured lipid carriers (NLCs) entrapped in a chitosan-based solid matrix containing ciprofloxacin (CPX). QRC-NLCs were prepared by homogenization followed by high-frequency sonication, and thereafter this dispersion was trapped in a chitosan-based CPX-loaded gel, obtaining the nanocomposite powder (BioQ-CPX) by lyophilization. BioQ-CPX displayed desirable properties such as high porosity (94.1 ± 0.5%), drug amounts (2.1% QRC and 3.5% CPX). and low swelling index (100%). Moreover, the mechanism of drug release from BioQ-CPX and their ability to be accumulated in the target tissue were in vitro and ex vivo elucidated, also by applying mathematical models. When trapped into the nanocomposite, QRC stressed under UV light exposure (50 W) was shown to maintain its antioxidant power, and CPX and QRC under natural light were stable over nine months. Finally, both the measured antioxidant power and the antimicrobial and antibiofilm properties on Staphylococcus aureus demonstrated that BioQ-CPX could be a promising platform to support the single-stage dental restorative treatment

The challenge and response to global tourism in the post-modern era: the commodification, reconfiguration and mutual transformation of Habana Vieja, Cuba

There is a growing literature on the symbolic and cultural meanings of tourism and the ways in which cities are increasingly competing for tourists through the promotion of cultural assets and different forms of spectacle in the `tourist bubble'. To date, research on the role and impact of tourism in cities has largely been confined to those in Western, post-industrial economies. This paper examines the growth of cultural tourism in the central area of Havana, Cuba, and explores the range of unique, devolved, state-owned enterprises that are attempting to use tourism as a funding mechanism to achieve improvements in the social and cultural fabric of the city for the benefit of residents. The paper concludes with an assessment of the implications of this example for our understanding of how the pressures for restructuring and commodification can be moderated at the city level. Copyright 2008 SAGE Publications. All rights reserved. Not for commercial use or unauthorized distribution

Anharmonic vibrations in nuclei

We show that the non-linearities of large amplitude motions in atomic nuclei induce giant quadrupole and monopole vibrations. As a consequence, the main source of anharmonicity is the coupling with configurations including one of these two giant resonances on top of any state. Two-phonon energies are often lowered by one or two MeV because of the large matrix elements with such three phonon configurations. These effects are studied in two nuclei, 40Ca and 208Pb

Strong enhancement of extremely energetic proton production in central heavy ion collisions at intermediate energy

The energetic proton emission has been investigated as a function of the reaction centrality for the system 58Ni + 58Ni at 30A MeV. Extremely energetic protons (EpNN > 130 MeV) were measured and their multiplicity is found to increase almost quadratically with the number of participant nucleons thus indicating the onset of a mechanism beyond one and two-body dynamics.Comment: 5 pages, 2 figures, submitted to Physical Review Letter

Cross sections relevant to gamma-ray line emission in solar flares:3^3He-induced reactions on 16^{16}O nuclei

Gamma-ray production cross sections have been measured for gamma-ray lines copiously emitted in the $^3$He bombardment of $^{16}$O nuclei: the 937, 1042 and 1081 keV lines of $^{18}$F and the 1887 keV line of $^{18}$Ne. Four Ge detectors with BGO shielding for Compton suppression were used to measure the angular distributions of the gamma-rays. The excitation functions have been obtained for $^3$He bombarding energies from 3.7 to 36 MeV. Total cross sections are tabulated for calculations relevant to gamma-ray astronomy. The importance of these lines as diagnosis for the presence and properties of accelerated $^3$He in solar flares is discussed in light of the measured cross sections.Comment: Phys. Rev. C68 (2003) 0258XX, in pres

Charge and current-sensitive preamplifiers for pulse shape discrimination techniques with silicon detectors

New charge and current-sensitive preamplifiers coupled to silicon detectors and devoted to studies in nuclear structure and dynamics have been developed and tested. For the first time shapes of current pulses from light charged particles and carbon ions are presented. Capabilities for pulse shape discrimination techniques are demonstrated.Comment: 14 pages, 12 figures, to be published in Nucl. Inst. Meth.