1,954 research outputs found
Surface plasmon resonance imaging for affinity-based biosensors
SPR imaging (SPRi) is at the forefront of optical label-free and real-time detection. It offers the possibility of monitoring hundreds of biological interactions simultaneously and from the binding profiles, allows the estimation of the kinetic parameters of the interactions between the immobilised probes and the ligands in solution. We review the current state of development of SPRi technology and its application including commercially available SPRi instruments. Attention is also given to surface chemistries for biochip functionalisation and suitable approaches to improve sensitivity
The impact of COVID-19 on the scientific production spread: A five-month bibliometric report of the worldwide research community
Introduction: The recent COVID-19 pandemic has gained recently a deep increasing of research interest in all fields of the human knowledge due to prevention of the Sars-Cov-2 infection and disease treatment The present investigation evaluated the topic publications and the citation network analysis during the early phases of COVID-19 pandemic spread. Methods: the Boolean search was performed according to the Pubmed Mesh terms by by Scopus Elsevier database. The papers, co-authors, number of citations obtained and scientific journals were recorded. Results: a total of 164 scientific journals were assessed in the present research with a mean impact factor value of 4.612±8.705 (range: 70.67-0; median: 2,687, Q1: 0,701; Q3: 4,928). Conclusions: The studies selected showed The bibliometric research showed an early representation of the research orientation of the research activity about COVID 19. The most represented scientific fields concerned with healthcare and medicine, while for the social and economic fields are gaining interests due to the pandemic spread
NGC 2782: a merger remnant with young stars in its gaseous tidal tail
We have searched for young star-forming regions around the merger remnant NGC
2782. By using GALEX FUV and NUV imaging and HI data we found seven UV sources,
located at distances greater than 26 kpc from the center of NGC 2782, and
coinciding with its western HI tidal tail. These regions were resolved in
several smaller systems when Gemini/GMOS r-band images were used. We compared
the observed colors to stellar population synthesis models and we found that
these objects have ages of ~1 to 11 Myr and masses ranging from 10^3.9 to
10^4.6 Msun. By using Gemini/GMOS spectroscopic data we confirm memberships and
derive high metallicities for three of the young regions in the tail
(12+log(O/H)=8.74\pm0.20, 8.81\pm0.20 and 8.78\pm0.20). These metallicities are
similar to the value presented by the nuclear region of NGC 2782 and also
similar to the value presented for an object located close to the main body of
NGC 2782. The high metallicities measured for the star-forming regions in the
gaseous tidal tail of NGC 2782 could be explained if they were formed out of
highly enriched gas which was once expelled from the center of the merging
galaxies when the system collided. An additional possibility is that the tail
has been a nursery of a few generations of young stellar systems which
ultimately polluted this medium with metals, further enriching the already
pre-enriched gas ejected to the tail when the galaxies collided.Comment: 11 pages, 5 figures. Accepted for publication in MNRA
A case of primary Hodgkin's lymphoma of the parotid gland. Case report and differentian diagnosis from Kuttner's Syndrom
Abstract
We report a rare case of primary Hodgkin’s lymphoma (HL) of the submandibular
gland, with initially diagnosis of Kuttner’s Syndrom. A 48 years old man was referred to our hospital foe evaluation
of a submandibular mass. Although the initial Fine Needle Aspiration and subsequent cytology was highly suggestive for a cronic sialadenitis with lymphoid cells.
After surgical gland removal we obtained a definitive diagnosis of Hodgkin’s lymphoma in
submandibular gland a seat where the most common lymphoma tipe is B
Which is the most accurate diagnostic procedure in Tamoxifen treated breast cancer patients
Purpose: The aim of this study was to evaluate the diagnostic accuracy of bi-dimensional (2D) and three-dimensional (3D) transvaginal ultrasound (TVUS), hysterosonography (HSSG) and hysteroscopy in the detection of endometrial pathology in women treated with tamoxifen (TMX) for breast cancer.
Methods: Forty-two patients, affected by breast cancer under treatment with TMX, underwent 2D-3D TVUS, HSSG and hysteroscopy completed by biopsy, after abnormal findings following a routine 2D TVUS examination.
Results: 3D-TVUS was more accurate than 2D-TVUS in the detection of atrophic endometrium confirmed by biopsy and in the detection of endometrial polyps.
HSSG and hysteroscopy detected atrophic endometrium and endometrial polyps significantly better than ultrasound scan. Endometrial carcinoma was detected in two cases, and in both HSSG and hysteroscopy were 100% diagnostic.
Conclusion: In TMX treated breast cancer patients, HSSG and hysteroscopy provide more accurate diagnosis than 2D-3D ultrasound in the detection of treatment related endometrial lesions
A possible solution of the puzzling variation of the orbital period of MXB 1659-298
MXB 1659-298 is a transient neutron star Low-Mass X-ray binary system that
shows eclipses with a periodicity of 7.1 hr. The source went to outburst in
August 2015 after 14 years of quiescence. We investigate the orbital properties
of this source with a baseline of 40 years obtained combining the eight eclipse
arrival times present in literature with 51 eclipse arrival times collected
during the last two outbursts. A quadratic ephemeris does not fit the delays
associated with the eclipse arrival times and the addition of a sinusoidal term
with a period of yr is required. We infer a binary orbital
period of hr and an orbital period derivative of
s s. We show that the large orbital
period derivative can be explained with a highly non conservative mass transfer
scenario in which more than 98\% of the mass provided by the companion star
leaves the binary system. We predict an orbital period derivative value of
s s and constrain the companion star
mass between 0.3 and M. Assuming that the
companion star is in thermal equilibrium the periodic modulation can be due to
either a gravitational quadrupole coupling due to variations of the oblateness
of the companion star or with the presence of a third body of mass M
Jovian masses.Comment: 10 pages, 6 figures. Accepted by MNRA
New Implant Design with Midcrestal and Apical Wing Thread for Increased Implant Stability in Single Postextraction Maxillary Implant
Background. The immediate placement of a dental implant could represent an option treatment for the rehabilitation of a postextractive missing tooth socket to replace compromised or untreatable teeth, with the advantage of single-session surgery. In this way, the anatomy of the alveolar bone defect, the preservation of the buccal cortical bone, and the primary stability of the fixture represent the critical factors that consent a precise implant placement. Objective. This case report describes a novel fixture design for postextractive alveolar socket immediate implant. Methods. Two patients (25 and 31 years old) were treated for postextractive dental implant placement to replace both central upper incisor teeth with four implants. The residual bone implant gap was not filled with graft or bone substitute. The restoration was provided following a standard loading protocol by a cement-sealed prosthetic abutment. Results. Clinically, all implants positioned showed an excellent insertion torque. No postoperative complications were reported. At 6 months of healing, the buccal cortical bone and the implant stability were present and well maintained. Conclusion. The evidence of this study allows us to underline the possible advantages of this new fixture design for postextractive implant technique
Aeroacoustics of sawtooth trailing-edge serrations under aerodynamic loading
The impact of aerodynamic loading on a serrated trailing edge is studied experimentally. Aerodynamic and acoustic measurements are conducted on a sawtooth-shaped trailing edge, retrofitted to a flat plate featuring a trailing-edge flap, and placed at incidence to the free-stream flow. The turbulent flow across the trailing edge is inspected by time-resolved three-dimensional velocity field measurements obtained from 4D-PIV, while the wall-pressure fluctuations are measured with surface-embedded microphones. Results discuss the relation between the velocity fluctuations over the serrations, the surface pressure fluctuations, and the far-field noise spectra. The aerodynamic analysis discusses the effect of counter-rotating vortex pairs, generated by the pressure imbalance across the edges of the serrations under loading. It is shown that the interaction of these vortices with the incoming turbulence affects the intensity of the wall-pressure spectrum at the outer rim of the serration surface. On the suction side, the intensity of the pressure fluctuations from the incoming boundary layer dominates over that induced by the vortex pairs. On the pressure side, instead, the velocity gradient prescribed by the vortex pairs produces a significant increase of the pressure fluctuations around the edges. The resulting spatial distribution of the wall-pressure fluctuations directly affects the far-field noise. Scattering predictions carried out with the wall-pressure fluctuations in the centre and root (on the suction side) exhibit good agreement with the measured noise in the low-frequency range, whereas using the surface pressure data at the tip of the serration (on the pressure side) yields a better prediction in the high-frequency range
Porous carbon spheres from poly(4-ethylstyrene-co-divinylbenzene): role of ZnCl2 and KOH agents in affecting porosity, surface area and mechanical properties
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