Impact of age and race on outcomes of a program to prevent excess weight gain and disordered eating in adolescent girls

Interpersonal psychotherapy (IPT) prevents weight gain and reduces loss-of-control (LOC)-eating in adults. However, IPT was not superior to health-education (HE) for preventing excess weight gain and reducing LOC-eating over 1-year in adolescent girls at risk for excess weight gain and eating disorders. Limited data suggest that older and non-White youth may be especially responsive to IPT. In secondary analyses, we examined if age or race moderated weight and LOC-eating outcomes. The 113 participants (12–17 years; 56.6% White) from the original trial were re-contacted 3 years later for assessment. At baseline and follow-up visits through 3 years, we assessed BMI, adiposity by dual energy X-ray absorptiometry, and LOC-eating presence. In linear mixed models, baseline age moderated 3-year BMI outcome; older girls in IPT had the lowest 3-year BMI gain compared to younger girls in IPT and all girls in HE, p = 0.04. A similar pattern was observed for adiposity. Race moderated 3-year LOC-eating; non-White girls in IPT were most likely to abstain from LOC-eating at 3 years compared to all other girls, p = 0.04. This hypothesis-generating analysis suggests future studies should determine if IPT is especially efficacious at reducing LOC-eating in older, non-White adolescents

THE USE OF N400 IN STUDIES OF STIMULUS EQUIVALENCE: A REVIEW OF METHODS AND PARAMETERS

The N400 is defined as an event-related brain potential that is sensitive to the semantic relations between stimuli. For instance, when a pair of words belong to the same semantic domain (e.g., monkey-banana), the N400 will be significantly reduced in comparison to the N400 evoked by unrelated words (e.g., monkey-carburetor). Notably, the N400 responses are also sensitive to the arbitrary stimulus-stimulus relations formed by matching-to-sample procedures (MTS), supporting the notion that stimulus equivalence is a behavioristic model of semantic relations. In this study, we presented a methodological review of studies on stimulus equivalence that used the N400 as dependent measure of “equivalent” and “non-equivalent” stimulus-stimulus relations formed by MTS procedures. First, we searched on databases for studies that used the descriptive terms “equivalence relations”, “matching-to-sample”, “MTS”, “N400”, “relational learning”, and “derived relations” on the title and the abstract. Then, we categorized the number of experiments in each study, population, nature of stimuli, the event-related brain potential used as a dependent measure and whether the critical probes comprised baseline, reflexive, symmetric or transitive relations. We found that the MTS variables differed substantially from one study to another. Considering that most of these MTS variables may be critical to the establishment of stimulus equivalence, we encourage follow-up studies that aim at verifying whether and to what extent they can be related to the N400 outcomes.Key-words: Matching-to-sample, equivalence-relatedness-based-procedure, stimulus equivalence, N400, semantic relations, methodological review

Coherent radar reflections from an electron-beam induced particle cascade

Experiment T-576 ran at SLAC in 2018, in development of a new radar-based detection scheme for ultra-high energy neutrinos. In this experiment, the electron beam (N∼109e− at ∼10 GeV) was directed into a plastic target to simulate a 1019 eV neutrino-induced shower in ice. This shower was interrogated with radio frequency (RF) radiation, in an attempt to measure a radar-like reflection from the ionization produced in the target during the particle shower. This technique could be employed to detect the rare interactions of ultra-high-energy neutrinos in dense material, such as polar ice sheets, extending the extant energy range of detected neutrinos up to EeV and beyond. In this proceeding, we detail the experiment and present results from the analysis and the observation of a signal consistent with a radar signal

Modeling in-ice radio propagation with parabolic equation methods

We investigate the use of parabolic equation (PE) methods for solving radio-wave propagation in polar ice. PE methods provide an approximate solution to Maxwell's equations, in contrast to full-field solutions such as finite-difference-time-domain (FDTD) methods, yet provide a more complete model of propagation than simple geometric ray-tracing (RT) methods that are the current state of the art for simulating in-ice radio detection of neutrino-induced cascades. PE are more computationally efficient than FDTD methods, and more flexible than RT methods, allowing for the inclusion of diffractive effects, and modeling of propagation in regions that cannot be modeled with geometric methods. We present a new PE approximation suited to the in-ice case. We conclude that current ray-tracing methods may be too simplistic in their treatment of ice properties, and their continued use could overestimate experimental sensitivity for in-ice neutrino detection experiments. We discuss the implications for current in-ice Askaryan-type detectors and for the upcoming Radar Echo Telescope; two families of experiments for which these results are most relevant. We suggest that PE methods be investigated further for in-ice radio applications

The Radar Echo Telescope for Neutrinos (RET-N)

We present the Radar Echo Telescope for Neutrinos (RET-N). RET-N focuses on the detection of the cosmic neutrino flux above PeV energies by means of the radar detection technique. This method aims to bridge the energy gap between the diffuse neutrino flux detected by IceCube up to a few PeV and the sought for cosmogenic neutrinos at EeV energies by the in-ice Askaryan detectors, as well as the air-shower radio detectors. The radar echo method is based on the detection the ionization trail in the wake of a high-energy neutrino-induced particle cascade in ice. This technique, recently validated in a beam test (T576 at SLAC) is also the basis for the RET-N pathfinder experiment, RET-CR, which is currently under development. Based on the T-576 results, we show that the radar echo method leads to very promising sensitivities to detect cosmic neutrinos in the PeV-EeV region and above. We present the RET-N project and the results of our sensitivity studies

Simulation and Optimisation for the Radar Echo Telescope for Cosmic Rays

The SLAC T-576 beam test experiment showed the feasibility of the radar detection technique to probe high-energy particle cascades in dense media. Corresponding particle-level simulations indicate that the radar method has very promising sensitivity to probe the > PeV cosmic neutrino flux. As such, it is crucial to demonstrate the in-situ feasibility of the radar echo method, which is the main goal of the current RET-CR experiment. Although the final goal of the Radar Echo Telescope is to detect cosmic neutrinos, we seek a proof of principle using cosmic-ray air showers penetrating the (high-altitude) Antarctic ice sheet. When an UHECR particle cascade propagates into a high-elevation ice sheet, it produces a dense in-ice cascade of charged particles which can reflect incoming radio waves. Using a surface cosmic-ray detector, the energy and direction of the UHECR can be reconstructed, and as such this constitutes a nearly ideal in-situ test beam to provide the proof of principle for the radar echo technique. RET-CR will consist of a transmitter array, receiver antennas and a surface scintillator plate array. Here we present the simulation efforts for RET-CR performed to optimise the surface array layout and triggering system, which affords an estimate of the expected event rate

Investigating signal properties of UHE particles using in-ice radar for the RET experiment

The Radar Echo Telescope (RET) experiment plans to use the radar technique to detect Ultra-High Energy (UHE) cosmic rays and neutrinos in the polar ice sheets. Whenever an UHE particle collides with an ice molecule, it produces a shower of relativistic particles, which leaves behind an ionization trail. Radio waves can be reflected off this trail and be detected in antennas. It is critical to understand such a radar signal's key properties as that will allow us to do vertex, angular and energy reconstruction of the primary UHE particle. We will discuss various simulation methods, which will fundamentally rely on ray tracing, to recreate the radar signal and test our reconstruction methods

Toward High Energy Neutrino Detection with the Radar Echo Telescope for Cosmic Rays (RET-CR)

The Radar Echo Telescope for Cosmic Rays (RET-CR) is a pathfinder experiment for the Radar Echo Telescope for Neutrinos (RET-N), a next-generation in-ice detection experiment for ultra high energy neutrinos. RET-CR will serve as the testbed for the radar echo method to probe high-energy particle cascades in nature, whereby a transmitted radio signal is reflected from the ionization left in its wake. This method, recently validated at SLAC experiment T576, shows promising preliminary sensitivity to neutrino-induced cascades above the energy range of optical detectors like IceCube. RET-CR intends to use an in-nature test beam: the dense, in-ice cascade produced when the air shower of an ultra high energy cosmic ray impacts a high-elevation ice sheet. This in-ice cascade, orders of magnitude more dense than the in-air shower that preceded it, is similar in profile and density to the expected cascade from a neutrino-induced cascade deep in the ice. RET-CR will be triggered using surface scintillator technology and will be used to develop, test, and deploy the hardware, firmware, and software needed for the eventual RET-N. We present the strategy, status, and design sensitivity of RET-CR, and discuss its application to eventual neutrino detection

Application of parabolic equation methods to in-ice radiowave propagation for ultra high energy neutrino detection experiments

Many ultra-high-energy neutrino-detection experiments seek radio wave signals from neutrino interactions deep within the polar ice, and an understanding of in-ice radio wave propagation is therefore of critical importance. The parabolic equation (PE) method for modeling the propagation of radio waves is a suitable intermediate between ray tracing and finite-difference time domain (FDTD) methods in terms of accuracy and computation time. The RET collaboration has developed the first modification of the PE method for use in modeling in-ice radio wave propagation for ultra high energy cosmic ray and neutrino detection experiments. In this proceeding we will detail the motivation for the development of this technique, the process by which it was modified for in-ice use, and showcase the accuracy of its results by comparing to FDTD and ray tracing

Health, not weight loss, focused programmes versus conventional weight loss programmes for cardiovascular risk factors:A systematic review and meta-analysis

© 2019 The Authors. Published by BMC. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website:Background: Obesity is a cardiovascular disease risk factor. Conventional weight loss (CWL) programmes focus on weight loss, however 'health, not weight loss, focused' (HNWL) programmes concentrate on improved health and well-being, irrespective of weight loss. What are the differences in CVD risk outcomes between these programmes? Aim: To conduct a systematic review and meta-analysis to compare the effects of HNWL with CWL programmes on cardiovascular disease risk factors. Methods: We searched CENTRAL, MEDLINE, EMBASE, PsycINFO, CINAHL, ASSIA, clinical trial registers, commercial websites and reference lists for randomised controlled trials comparing the two programmes (initially searched up to August 2015 and searched updated to 5 April 2019). We used the Mantel-Haneszel fixed-effect model to pool results. Sub-group and sensitivity analyses that accounted for variations in length of follow-up, enhanced programmes and risk of bias dealt with heterogeneity. Results: Eight randomised controlled trials of 20,242 potential studies were included. Improvements in total cholesterol-HDL ratio (mean difference-0.21 mmol/L, 95% confidence interval [-3.91, 3.50]) and weight loss (-0.28 kg [-2.00, 1.44]) favoured HNWL compared to CWL programmes in the long term (53-104 week follow-up), whereas improvements in systolic (-1.14 mmHg, [-5.84, 3.56]) and diastolic (-0.15 mmHg, [-3.64, 3.34]) blood pressure favoured CWL programmes. These differences did not reach statistical significance. Statistically significant improvements in body satisfaction (-4.30 [-8.32,-0.28]) and restrained eating behaviour (-4.30 [-6.77,-1.83]) favoured HNWL over CWL programmes. Conclusions: We found no long-term significant differences in improved CVD risk factors; however, body satisfaction and restrained eating behaviour improved more with HNWL compared to CWL programmes. Yet firm conclusions cannot be drawn from small studies with high losses to follow-up and data sometimes arising from a single small study.Published versio