Breast cancer in association with thyroid disorders

BACKGROUND: The relationship between breast cancer and thyroid diseases is controversial. Discrepant results have been reported in the literature. The incidences of autoimmune and nonautoimmune thyroid diseases were investigated in patients with breast cancer and age-matched control individuals without breast or thyroid disease. METHODS: Clinical and ultrasound evaluation of thyroid gland, determination of serum thyroid hormone and antibody levels, and fine-needle aspiration of thyroid gland were performed in 150 breast cancer patients and 100 control individuals. RESULTS: The mean values for anti-thyroid peroxidase antibodies were significantly higher in breast cancer patients than in control individuals (P = 0.030). The incidences of autoimmune and nonautoimmune thyroid diseases were higher in breast cancer patients than in control individuals (38% versus 17%, P = 0.001; 26% versus 9%, P = 0.001, respectively). CONCLUSION: Our results indicate an increased prevalence of autoimmune and nonautoimmune thyroid diseases in breast cancer patients

Barriers to powering past coal: implications for a just energy transition in South Africa

The feasibility of South Africa's just energy transition, as dictated by the speed of phasing out coal and scaling up renewables, will rest on a range of techno-economic, socio-political, and socio-technical factors. Interactions between these dimensions of the transition carry significant implications for energy justice. In response, this paper proposes the Just Transition Feasibility Framework (JTFF) to better evaluate how feasibility constraints may impact South Africa's energy transition ambitions, and its more recent commitments to energy justice. Drawing on qualitative findings from interviews with South African energy experts, the study provides critical insights on the national- and community-scale implications of current energy policies. The analysis highlights socio-political constraints related to the Renewable Independent Power Producer Programme (REI4P) which aggravate energy vulnerabilities and misrecognition of places. In addition to strategically tackling a range of techno-economic and socio-technical constraints which are seen to exacerbate distributive injustice, the South African government should extend the 50 km radius scheme of the REI4P to a wider and more inclusive regional basis. Foremost, policy interventions must seek to realign South Africa's Minerals Energy Complex towards a just transition pathway committed to renewable electrification, community empowerment, and sustainable socio-economic structures.QR GCRF (UKRI

Sigmoid Colon Perforation Mimics a Tuboovarian Absces

PubMed: 29736107Introduction: An adnexal mass may be diagnosed after a routine pelvic ultrasonographic examination or an emergent hospital admission due to rupture of ectopic pregnancy, adnexal torsion or rupture of tuboovarian abscess. It is necessary to evaluate the origin of the mass initially and to classify patients who need further evaluation and treatment for an urgent condition.Case presentation: We report a case of sigmoid colon rupture due to sigmoid colon adenocarcinoma presenting as acute abdomen with left adnexal mass in a 28 years old woman. Abdominopelvic computed tomography revealed a left adnexal mass with suspicion of tuboovarian abscess. In laparatomy, rupture of sigmoid colon was observed and resection of sigmoid colon was performed. Histological examination of resection part revealed diagnosis of sigmoid colon adenocarcinoma due to familial adenomatous polyposis.Conclusion: This case may be interesting for clinicians because pelvic pain, fever, increased infection markers in the laboratory and mass at ultrasonography or other screening methods could cause a misdiagnosis of tubaovarian abscess especially in reproductive age women. Before the operation of the pelvic mass of all age women with the diagnosis of tuboovarian abscess other causes of the pelvic abscess should come into mine and necessary preparation for operation must be done

What is the protective effect of krill oil on rat ovary against ischemia–reperfusion injury?

PubMed: 30484932Aim: In this study, we aimed to investigate the protective effect of krill oil (KO) against ischemia–reperfusion (I/R) injury on rat ovary. Methods: This study was conducted with 32 Wistar Albino rats. Rats were divided into four groups, with eight rats in each group-as follows: Sham group, I/R group, I/R + low dose KO group (50 mg) and I/R + high dose KO group (500 mg). The histopathological and follicle counts were performed on the right ovary. The total antioxidant status, total oxidant status and oxidative stress index were evaluated on the left ovary. And also serum N-thiol level, serum T-thiol level, serum disulfide (SDS) level, serum disulfide/N-thiol and serum disulfide/T-thiol ratios were evaluated too. Results: A statistically significant difference was determined between the I/R group and all the other groups for all parameters. There was significant difference between KO groups and the Sham group for the parameters of serum N-thiol, serum T-thiol, SDS, serum disulfide/N-thiol and serum disulfide/T-thiol. SDS, total oxidant status and oxidative stress index were determined to be the highest in the I/R group and the lowest in the low dose KO group. The total antioxidant status values were found to be the highest in the high dose KO group and the lowest in the I/R group. Follicle counts and histological injury scores showed no significant difference between Sham and KO groups. Conclusion: This study demonstrated that KO has beneficial effects on decreasing the injury after I/R on rat ovary. © 2018 Japan Society of Obstetrics and Gynecology2018/003This research was funded by Kırıkkale University Scientific Research Commission (Project number: 2018/003). The authors are grateful to the staff members of Kırıkkale University for their valuable support

What is the protective effect of krill oil on rat ovary against ischemia-reperfusion injury?

Ozkan, Zehra Sema/0000-0001-9185-3663; EREL, Ozcan/0000-0002-2996-3236WOS: 000460180500012PubMed: 30484932Aim In this study, we aimed to investigate the protective effect of krill oil (KO) against ischemia-reperfusion (I/R) injury on rat ovary. Methods This study was conducted with 32 Wistar Albino rats. Rats were divided into four groups, with eight rats in each group-as follows: Sham group, I/R group, I/R + low dose KO group (50 mg) and I/R + high dose KO group (500 mg). The histopathological and follicle counts were performed on the right ovary. The total antioxidant status, total oxidant status and oxidative stress index were evaluated on the left ovary. And also serum N-thiol level, serum T-thiol level, serum disulfide (SDS) level, serum disulfide/N-thiol and serum disulfide/T-thiol ratios were evaluated too. Results A statistically significant difference was determined between the I/R group and all the other groups for all parameters. There was significant difference between KO groups and the Sham group for the parameters of serum N-thiol, serum T-thiol, SDS, serum disulfide/N-thiol and serum disulfide/T-thiol. SDS, total oxidant status and oxidative stress index were determined to be the highest in the I/R group and the lowest in the low dose KO group. The total antioxidant status values were found to be the highest in the high dose KO group and the lowest in the I/R group. Follicle counts and histological injury scores showed no significant difference between Sham and KO groups. Conclusion This study demonstrated that KO has beneficial effects on decreasing the injury after I/R on rat ovary.Krkkale University Scientific Research Commission [2018/003]This research was funded by Krkkale University Scientific Research Commission (Project number: 2018/003). The authors are grateful to the staff members of Krkkale University for their valuable support

Community acquired infections in elderly population

In geriatric practice, data regarding infections including the epidemiology, morbidity, and mortality are lacking. Our aim was to evaluate the frequency, location, microbiological and laboratory characteristics of infectious diseases in elderly population admitted to a training hospital. The patients were included total of 330 patients, aged over 65 with infection, seen between January 1, 2005 and January 1, 2006. In the result, of patients 136 (41%) had respiratory system infection, 90 (27%) urinary system infection, 39 (12%) gastrointestinal system infection, 34 (10%) bloodstream infections, 17 (5%) soft tissue infection, 8 (2%) central nervous system infections, and 6 (2%) others. Average length of hospitalization was 8.6 +/- 7.7 days. Mortality rate from all causes was 57 (17%). The most common infections in elderly patients were respiratory tract and urinary system infections, and there were no fever, leukocytes and high CRP levels in approximately 1/3 of cases. Infectious diseases may occur even in the absence of such infection indicators as fever, raised WBC count and high CRP level in the elderly population

Investigation of the protective effect of erythropoietin against cisplatin-induced ovarian damage: a rat model

33rd Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE) -- JUL 02-05, 2017 -- Geneva, SWITZERLANDOzkan, Zehra Sema/0000-0001-9185-3663WOS: 000416390501066…European Soc Human Reprod & Embryo