Information Technology for Processing of Industrial BigData with Distributed Infrastructure on the Basis of Smart Agents and Parallel Algorithms

Volume 7 Issue 9 (September 201

Vitamin D supplementation to treat SARS-CoV-2 positive patients. Evidence from meta-analysis

Background: Vitamin D is a likely candidate for treatment as its immune modulating characteristics have effects on coronavirus disease 2019 (COVID-19) patients. It was  sought herein, to summarize the studies published to date regarding the vitamin D supplementation to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients. Methods: A systematic review and meta-analysis were performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The primary outcome were 14-day and in-hospital mortality reported as an odds ratio (OR) with the associated 95% confidence interval (CI). Results: Eight articles were included in the review with a combined total of 2,322 individual patients, 786 in the vitamin D supplementation group and 1,536 in the control group. The use of vitamin D compared to the group without vitamin D supplementation was associated with a lower 14-day mortality (18.8% vs. 31.3%, respectively; OR = 0.51; 95% CI: 0.12–2.19; p = 0.36), a lower in-hospital mortality (5.6% vs. 16.1%; OR = 0.56; 95% CI: 0.23–1.37; I2 = 74%; p = 0.20), the rarer intensive care unit admission (6.4% vs. 23.4%; OR = 0.19; 95% CI: 0.06–0.54; I2 = 77%; p = 0.002) as well as rarer mechanical ventilation (6.5% vs. 18.9%; OR = 0.36; 95% CI: 0.16–0.80; I2 = 0.48; p = 0.01). Conclusions: Vitamin D supplementation in SARS-CoV-2 positive patients has the potential to positively impact patients with both mild and severe symptoms. As several high-quality randomized control studies have demonstrated a benefit in hospital mortality, vitamin D should be considered a supplemental therapy of strong interest. Should vitamin D prove to reduce hospitalization rates and symptoms outside of the hospital setting, the cost and benefit to global pandemic mitigation efforts would be substantial

Place of tranexamic acid in traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials

BACKGROUND: Traumatic brain injury (TBI) is a leading cause of death and disability. In many cases of TBI-related intracranial hemorrhage (ICH) is associated with a high risk of coagulopathy and may lead to an increased risk of hemorrhage growth. Therefore, tranexamic acid (TXA), which is known as an antifibrinolytic agent that reduces bleeding by inhibiting the breakdown of blood clots, might limit ICH expansion.   MATERIAL AND METHODS: We aimed to quantify the effects of TXA in brain injury and thus performed a literaturę search using PubMed, Web of Science, Scopus, EMBASE, and Cochrane Center Register of Controlled Trials (CENTRAL) for studies that were published between the respective database inception, and April 10, 2021.   RESULTS: A total of nine studies were identified; these included 5845 patients treated with, and 5380 treated without TXA. The 28-day or in-hospital mortality was 17.8% for the TXA group, compared with 19.3% for the no-TXA group (OR = 0.92; 95% CI: 0.83, 1.01; p = 0.08). At 6-months follow-up, mortality was 18.3% vs 19.9% (OR = 0.91; 95% CI: 0.63–1.31; p = 0.60), with and without TXA, respectively. A Glasgow Outcome Scale less than 4 points at 28-days follow-up was reported in 3 studies and was 29.8% vs 34.8% (OR = 0.91; 95% CI: 0.45, 1.82; p = 0.78), with and without TXA, respectively. No differences were found in adverse events between TXA and non-TXA groups.   CONCLUSION: Our analysis found showed no statistical significance between TXA and non-TXA treatment of TBI patients, however, in the TXA group a trend to decrease 28-day mortality compared to non-TXA treatment was observed. More high-quality studies are needed to show the significant benefit of using TXA, especially in moderate and severe TBI patient groups

The study of amino acids level in the vitreous body of experimental animals in regamatogenous retinal detachment

INTRODUCTION: The paper presents the results of the amino acid levels study in the vitreous body of rats with rhegmatogenous retinal detachment (RRD).MATERIAL AND METHODS: Experimental studies were performed on 42 brown Norwegian male rats (Male Brown Norway), which were divided into 7 groups (6 animals in each group): 1 group — conditionally intact control (without retinal detachment) — animals that underwent paracentesis of the anterior chamber with the removal of its moisture and retinal puncture without the introduction of any substance under the retina; 2 group — rats, which reproduced RRD by the method (control pathology) based on the study of apoptosis induction by apoptosis-inducing factor.RESULTS: In the group of conditionally intact control animals the concentration of amino acids in vitreous body were: alanine — 3.3 ± 0.27 ng/mL; arginine — 0.8 ± 0.1 ng/mL; aspartate — 2.3 ± 0.5 ng/mL; valine — 1.8 ± 0.8 ng/mL; histidine — 1.3 ± 0.3 ng/mL; glycine — 4.5 ± 0.8 ng/mL; glutamic acid — 1.56 ± 0.35 ng/mL; tyrosine — 0.084 ± 0.048 ng/mL; phenylalanine — 0.024 ± 0.017 ng/mL; methionine — 0.11 ± 0.1 ng/mL. In animals with model pathology of RRD was observed a significant increase in certain amino acids: the level of alanine increased 1.4 times, aspartate — 11.5 times (p < 0.05), glycine — 2.3 times (p < 0.05), glutamic acid — 7.9 times (p < 0.05) compared with rats of the conditionally intact group. Levels of other amino acids increased insignificantly.CONCLUSIONS: The most pronounced therapeutic efficacy was found in rats treated with combination therapy with dexamethasone, resveratrol, erythropoietin, and edaravon for 7 days. The pronounced effect of combination therapy on the level of amino acids (aspartate, glutamate, alanine, and glycine) in the treatment of RRD is due to the pharmacological activity of the components of this therapeutic regimen and characterized by synergistic effects of each component in the key links of disease pathogenesis

A study on the lipid peroxidation status and the antioxidant system in rats at experimental diabetic retinopathy

Semenko Volodymyr Volodymyrovych, Serdyuk Valeriy Mykolayovych, Savytskyi Ivan Volodymyrovych. A study on the lipid peroxidation status and the antioxidant system in rats at experimental diabetic retinopathy. Journal of Education, Health and Sport. 2017;7(6):870-887. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1050420 http://ojs.ukw.edu.pl/index.php/johs/article/view/5041 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 03.06.2017. Revised: 20.06.2017. Accepted: 30.06.2017. A STUDY ON THE LIPID PEROXIDATION STATUS AND THE ANTIOXIDANT SYSTEM IN RATS AT EXPERIMENTAL DIABETIC RETINOPATHY 1Volodymyr Volodymyrovych Semenko, 1Valeriy Mykolayovych Serdyuk, 2Ivan Volodymyrovych Savytskyi 1Dnipropetrovsk Regional Clinical Ophthalmologic Hospital 2Odessa National Medical University Abstract Activation of free radical oxidation is one of the key elements of the diabetes mellitus pathogenesis that leads to structural and functional disruption of membranes. Oxidative stress and imbalance between its intensity and the antioxidant system condition, comply with the data obtained from the literature, play an important role in the development of this disease complications. The defect of β-cells of Langerhans islets caused by hyperglycemia enhanced oxidative stress, is also substantially affect the progression of diabetes and its complications. The aim of this work is to study the status of lipid peroxidation and the antioxidant system at experimental diabetes, as well as to study the effectiveness of arginine corrective action. Wistar outbreeding white rats were used in the study, with the weight of 180-200 g. Comply with objectives of the work, animals were ranked into 3 groups: group 1– 20 animals that were not subjected to any influence; they served as control; group 2 – 30 animals in which diabetes mellitus was simulated; group 3 – 30 animals were aimed to receive a 7 % arginine solution, against the backdrop of diabetes. Diabetes was modeled with an intraperitoneal three times delivery of alloxan at a dose of 7.5 ml, with 5 days interval. Delivery of alloxan have been carried out with the animals free drinking of 5% fructose solution. The experiment lasted 30 days. Scientists witnessed 100% survival of experimental rats while applying this model. Activation of lipid peroxidation was detected with the alloxan diabetes model, as evidenced by an increase in the MDA and diene conjugates content in blood serum. There is a decrease in the catalase and superoxide dismutase activity at the experimental diabetes. Corrective action of arginine has led to a decrease in lipid peroxidation (LPO) processes and to the antioxidant system activation. Keу words: experimental diabetes mellitus, alloxanic model, oxidization of peroxide of lipids, antioxidant system, dien conjugates, malonic dialdehyde, superoxideddismutasa, katalas

Vitamin D supplementation to treat SARS-CoV-2 positive patients. Evidence from meta-analysis

BACKGROUND: Vitamin D is a likely candidate for treatment as its immune modulating characteristics have effects on coronavirus disease 2019 (COVID-19) patients. It was sought herein, to summarize the studies published to date regarding the vitamin D supplementation to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients. METHODS: A systematic review and meta-analysis were performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The primary outcome were 14-day and in-hospital mortality reported as an odds ratio (OR) with the associated 95% confidence interval (CI). RESULTS: Eight articles were included in the review with a combined total of 2,322 individual patients, 786 in the vitamin D supplementation group and 1,536 in the control group. The use of vitamin D compared to the group without vitamin D supplementation was associated with a lower 14-day mortality (18.8% vs. 31.3%, respectively; OR = 0.51; 95% CI: 0.12-2.19; p = 0.36), a lower in-hospital mortality (5.6% vs. 16.1%; OR = 0.56; 95% CI: 0.23-1.37; I2 = 74%; p = 0.20), the rarer intensive care unit admission (6.4% vs. 23.4%; OR = 0.19; 95% CI: 0.06-0.54; I2 = 77%; p = 0.002) as well as rarer mechanical ventilation (6.5% vs. 18.9%; OR = 0.36; 95% CI: 0.16-0.80; I2 = 0.48; p = 0.01). CONCLUSIONS: Vitamin D supplementation in SARS-CoV-2 positive patients has the potential to positively impact patients with both mild and severe symptoms. As several high-quality randomized control studies have demonstrated a benefit in hospital mortality, vitamin D should be considered a supplemental therapy of strong interest. Should vitamin D prove to reduce hospitalization rates and symptoms outside of the hospital setting, the cost and benefit to global pandemic mitigation efforts would be substantial

Ефективність локального утеплення заглиблених будівель

Эффективность локального утепления заглубленных зданий / И. И. Куличенко, Н. В. Савицкий, Т. Д. Никифорова, А. Э. Гуслистая // Строительство. Материаловедение. Машиностроение. - 2003. – № 25. – С. 47 – 51.RU: В статье рассматриваются различные решения утепления наружных ограждающих конструкций. Для повышения энергоэффективности заглубленных сооружений, расположенных на склонах, приводятся результаты сравнения эффективности рассмотренных технических решений.UK: У статті розглядаються різні рішення утеплення зовнішніх огороджувальних конструкцій. Для підвищення енергоефективності заглиблених споруд, розташованих на схилах, наводяться результати порівняння ефективності розглянутих технічних рішень

Energy, Technical and Economic Efficiency of Multifunctionallandslide Control Earth Sheltered Structures

Энерго- и технико-экономическая эффективность многофункциональных противооползневых заглубленных зданий / Н. В. Савицкий, И. И. Куличенко, В. І. Большаков [и др.] // Теоретичні основи будівництва. - 2003 – № 11. – С. 235 – 240.RU: Целью статьи является дать читателю некоторую информацию по вопросам, связанным с мерами контроля за оползнями на территории Украины.UK: Метою статті є дати читачеві деяку інформацію з питань, пов'язаних із заходами контролю за зсувами на території Україні.EN: The purpose of the article is to give the reader some information on questions connected with landslide control measures on the territory of Ukraine. The multifunctional earth sheltered landslide control structures are being proposed as an innovation for landslide control. Energy, technical and economic efficiency of multifunctional structures is being investigated