WOM: Whole ORC Model

Over the last decade, environmental and economic concerns have pushed the researchers to find new solutions in the track of a more responsible use of energy. Particularly, small scale organic Rankine cycles (ORCs) have been regarded as candidate for a better employment of waste energy. In order to increase the performance of these cycles and to extend their operating range, attention has been drawn on the behavior of the different components both experimentally as well as by means of computational fluid dynamics (CFD) simulations. The numerical approach has been increasingly used in the study of the machines that compose the cycle, avoiding the problems that typically affect the experimental analyses, e.g. compatibility of refrigerant with sealing systems, and allowing for the preliminary test of new machines to be added to the cycle. In this work, the numerical analysis will be focused not only on the single components considered as a stand-alone, but rather extended on their reciprocal interaction and on the system integration of the different machines. A Whole ORC Model (WOM), can thus be built and employed as a virtual test bench. Such a virtual model can be of paramount importance in predicting the behavior of the cycle in off-design conditions or in gathering information about fluid stagnation locations. The analysis can be even extended by coupling the WOM with the external world. Specifically, the grid demand and the heat flux at the evaporator can vary: such change is translated in a variation in the boundary conditions. The response of the cycle to the external variation can be therefore monitored and studied. A full three-dimensional, transient analysis and the framework in which the WOM is developed are presented in this work. The numerical strategies employed are described, with particular attention to the fashion in which the real gas effect of the working fluid and the motion inside the positive displacement machines are treated. The performance variation in response to an external change is reported to show the capability of the virtual test bench in helping both the system conductor as well as the designer

experimental and numerical characterization of an oil free scroll expander

Abstract Micro-ORC systems are characterized by low efficiency values, but at the same time could be used as energy recovery systems in domestic applications for which reliability and low noise level represent the biggest challenges. In this paper, an integrated Reverse Engineering (RE)-Computational Fluid Dynamics (CFD) methodology is applied in order to study the adaptation of a commercial scroll compressor to be used as an expander in a micro-ORC system. The analyses reported in this paper consist of: (i) the acquisition of the 5-kW oil-free scroll expander through a RE procedure and its CAD reconstruction, (ii) the set-up of fully three-dimensional transient simulations with the Chimera strategy using the Siemens PLM software, (iii) the validation of the computational analysis by means of experimental tests and finally, (iv) the analysis of the geometry-flow features like flank and axial gaps, coupled with the analysis of the scroll volumetric efficiency and overall performance. Chimera strategy is able to move the computational grid at each time step in order to accommodate the shape and size changes of the gas pockets. The scroll characterization was carried out using both experimental and numerical tests. Six different rotational velocities in the range of (400 – 2400) rpm with a fixed pressure level (7.5 bar) were tested for validating the numerical model using air as a working fluid. The numerical model was then used to calculate the scroll expander performance operating in an existing ORC system with R134a as working fluid

Substance use and psychiatric symptoms in subjects referred to the Drug Addiction Services by the Prefecture

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Experimental and Numerical Analysis of a Non-Newtonian Fluids Processing Pump

Abstract Centrifugal pumps are used in many applications in which non-Newtonian fluids are involved: food processing industry, pharmaceutical and oil/gas applications. In addition to pressure and temperature, the viscosity of a non-Newtonian fluid depends on the shear rate and usually is several orders of magnitude higher than water. High values of viscosity cause a derating of pump performance with respect to water. Nowadays, pumping and mixing non-Newtonian fluids is a matter of increasing interest, but there is still lack of a detailed analysis of the fluid-dynamic phenomena occurring within these machines. A specific design process should take into account these effects in order to define the proper pump geometry, able to operate with non-Newtonian fluids with specific characteristics. Only few approaches are available for correcting the pump performance based on the Hydraulic Institute method. In this work, an experimental and numerical campaign is presented for a semi–open impeller centrifugal pump elaborating non-Newtonian fluids. An on-purpose test bench was built and used to investigate the influence on pump performance of three different non-Newtonian fluids. Each pump performance test was accompanied by the rheological characterization of the fluid, in order to detect modifications of the rheological phenomena and allow a proper Computation Fluid Dynamics (CFD) modeling. The performance of the machine handling both Newtonian and non-Newtonian fluids are highlighted in relation with the internal flow field

Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register

Diabetes is an increasing global health burden with the highest prevalence (24.0%) observed in elderly people. Older diabetic adults have a greater risk of hospitalization and several geriatric syndromes than older nondiabetic adults. For these conditions, special care is required in prescribing therapies including anti- diabetes drugs. Aim of this study was to evaluate the appropriateness and the adherence to safety recommendations in the prescriptions of glucose-lowering drugs in hospitalized elderly patients with diabetes. Data for this cross-sectional study were obtained from the REgistro POliterapie-Società Italiana Medicina Interna (REPOSI) that collected clinical information on patients aged ≥ 65 years acutely admitted to Italian internal medicine and geriatric non-intensive care units (ICU) from 2010 up to 2019. Prescription appropriateness was assessed according to the 2019 AGS Beers Criteria and anti-diabetes drug data sheets.Among 5349 patients, 1624 (30.3%) had diagnosis of type 2 diabetes. At admission, 37.7% of diabetic patients received treatment with metformin, 37.3% insulin therapy, 16.4% sulfonylureas, and 11.4% glinides. Surprisingly, only 3.1% of diabetic patients were treated with new classes of anti- diabetes drugs. According to prescription criteria, at admission 15.4% of patients treated with metformin and 2.6% with sulfonylureas received inappropriately these treatments. At discharge, the inappropriateness of metformin therapy decreased (10.2%, P < 0.0001). According to Beers criteria, the inappropriate prescriptions of sulfonylureas raised to 29% both at admission and at discharge. This study shows a poor adherence to current guidelines on diabetes management in hospitalized elderly people with a high prevalence of inappropriate use of sulfonylureas according to the Beers criteria

Antidiabetic Drug Prescription Pattern in Hospitalized Older Patients with Diabetes

Objective: To describe the prescription pattern of antidiabetic and cardiovascular drugs in a cohort of hospitalized older patients with diabetes. Methods: Patients with diabetes aged 65 years or older hospitalized in internal medicine and/or geriatric wards throughout Italy and enrolled in the REPOSI (REgistro POliterapuie SIMI—Società Italiana di Medicina Interna) registry from 2010 to 2019 and discharged alive were included. Results: Among 1703 patients with diabetes, 1433 (84.2%) were on treatment with at least one antidiabetic drug at hospital admission, mainly prescribed as monotherapy with insulin (28.3%) or metformin (19.2%). The proportion of treated patients decreased at discharge (N = 1309, 76.9%), with a significant reduction over time. Among those prescribed, the proportion of those with insulin alone increased over time (p = 0.0066), while the proportion of those prescribed sulfonylureas decreased (p < 0.0001). Among patients receiving antidiabetic therapy at discharge, 1063 (81.2%) were also prescribed cardiovascular drugs, mainly with an antihypertensive drug alone or in combination (N = 777, 73.1%). Conclusion: The management of older patients with diabetes in a hospital setting is often sub-optimal, as shown by the increasing trend in insulin at discharge, even if an overall improvement has been highlighted by the prevalent decrease in sulfonylureas prescription

The “Diabetes Comorbidome”: A Different Way for Health Professionals to Approach the Comorbidity Burden of Diabetes

(1) Background: The disease burden related to diabetes is increasing greatly, particularly in older subjects. A more comprehensive approach towards the assessment and management of diabetes’ comorbidities is necessary. The aim of this study was to implement our previous data identifying and representing the prevalence of the comorbidities, their association with mortality, and the strength of their relationship in hospitalized elderly patients with diabetes, developing, at the same time, a new graphic representation model of the comorbidome called “Diabetes Comorbidome”. (2) Methods: Data were collected from the RePoSi register. Comorbidities, socio-demographic data, severity and comorbidity indexes (Cumulative Illness rating Scale CIRS-SI and CIRS-CI), and functional status (Barthel Index), were recorded. Mortality rates were assessed in hospital and 3 and 12 months after discharge. (3) Results: Of the 4714 hospitalized elderly patients, 1378 had diabetes. The comorbidities distribution showed that arterial hypertension (57.1%), ischemic heart disease (31.4%), chronic renal failure (28.8%), atrial fibrillation (25.6%), and COPD (22.7%), were the more frequent in subjects with diabetes. The graphic comorbidome showed that the strongest predictors of death at in hospital and at the 3-month follow-up were dementia and cancer. At the 1-year follow-up, cancer was the first comorbidity independently associated with mortality. (4) Conclusions: The “Diabetes Comorbidome” represents the perfect instrument for determining the prevalence of comorbidities and the strength of their relationship with risk of death, as well as the need for an effective treatment for improving clinical outcomes

Clinical features and outcomes of elderly hospitalised patients with chronic obstructive pulmonary disease, heart failure or both

Background and objective: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) mutually increase the risk of being present in the same patient, especially if older. Whether or not this coexistence may be associated with a worse prognosis is debated. Therefore, employing data derived from the REPOSI register, we evaluated the clinical features and outcomes in a population of elderly patients admitted to internal medicine wards and having COPD, HF or COPD + HF. Methods: We measured socio-demographic and anthropometric characteristics, severity and prevalence of comorbidities, clinical and laboratory features during hospitalization, mood disorders, functional independence, drug prescriptions and discharge destination. The primary study outcome was the risk of death. Results: We considered 2,343 elderly hospitalized patients (median age 81 years), of whom 1,154 (49%) had COPD, 813 (35%) HF, and 376 (16%) COPD + HF. Patients with COPD + HF had different characteristics than those with COPD or HF, such as a higher prevalence of previous hospitalizations, comorbidities (especially chronic kidney disease), higher respiratory rate at admission and number of prescribed drugs. Patients with COPD + HF (hazard ratio HR 1.74, 95% confidence intervals CI 1.16-2.61) and patients with dementia (HR 1.75, 95% CI 1.06-2.90) had a higher risk of death at one year. The Kaplan-Meier curves showed a higher mortality risk in the group of patients with COPD + HF for all causes (p = 0.010), respiratory causes (p = 0.006), cardiovascular causes (p = 0.046) and respiratory plus cardiovascular causes (p = 0.009). Conclusion: In this real-life cohort of hospitalized elderly patients, the coexistence of COPD and HF significantly worsened prognosis at one year. This finding may help to better define the care needs of this population

Pressure Pulsation and Cavitation Phenomena in a Micro-ORC System

Micro-ORC systems are usually equipped with positive displacement machines such as expanders and pumps. The pumping system has to guarantee the mass flow rate and allows a pressure rise from the condensation to the evaporation pressure values. In addition, the pumping system supplies the organic fluid, characterized by pressure and temperature very close to the saturation. In this work, a CFD approach is developed to analyze from a novel point of view the behavior of the pumping system of a regenerative lab-scale micro-ORC system. In fact, starting from the liquid receiver, the entire flow path, up to the inlet section of the evaporator, has been numerically simulated (including the Coriolis flow meter installed between the receiver and the gear pump). A fluid dynamic analysis has been carried out by means of a transient simulation with a mesh morphing strategy in order to analyze the transient phenomena and the effects of pump operation. The analysis has shown how the accuracy of the mass flow rate measurement could be affected by the pump operation being installed in the same circuit branch. In addition, the results have shown how the cavitation phenomenon affects the pump and the ORC system operation compared to control system actions