Therapeutic Delivery Technology and its Economic Impact

Therapeutic delivery technology is a current area of high interest in both university and industrial settings. These technologies are being developed in order to deliver therapeutic agents, such as genes, proteins, and drugs, to patients more efficiently. Nanoscale delivery vehicles have proven to be useful for these applications; these vehicles may either be naturally produced or chemically synthesized. The physical properties of these nanomaterials must be characterized correctly using instrumentation that evaluates their size, morphology, and potential for agglomeration. These technologies represent a high-growth economic area that fosters entrepreneurship and innovation. Because of this innovative spirit, research and economic interest will continue to be focused on therapeutic delivery technologies

Transforming carbon nanotubes by silylation: An ab initio study

We use ab initio density functional calculations to study the chemical functionalization of single-wall carbon nanotubes and graphene monolayers by silyl (SiH3) radicals and hydrogen. We find that silyl radicals form strong covalent bonds with graphene and nanotube walls, causing local structural relaxations that enhance the sp3 character of these graphitic nanostructures. Silylation transforms all carbon nanotubes into semiconductors, independent of their chirality. Calculated vibrational spectra suggest that specific frequency shifts can be used as a signature of successful silylation.Comment: 4 pages, 3 figure

Low velocity quantum reflection of Bose-Einstein condensates

We studied quantum reflection of Bose-Einstein condensates at normal incidence on a square array of silicon pillars. For incident velocities of 2.5-26 mm/s observations agreed with theoretical predictions that the Casimir-Polder potential of a reduced density surface would reflect slow atoms with much higher probability. At low velocities (0.5-2.5 mm/s), we observed that the reflection probability saturated around 60% rather than increasing towards unity. We present a simple model which explains this reduced reflectivity as resulting from the combined effects of the Casimir-Polder plus mean field potential and predicts the observed saturation. Furthermore, at low incident velocities, the reflected condensates show collective excitations.Comment: 4 figure

Black Holes at the LHC

If the scale of quantum gravity is near a TeV, the LHC will be producing one black hole (BH) about every second. The BH decays into prompt, hard photons and charged leptons is a clean signature with low background. The absence of significant missing energy allows the reconstruction of the mass of the decaying BH. The correlation between the BH mass and its temperature, deduced from the energy spectrum of the decay products, can test experimentally the higher dimensional Hawking evaporation law. It can also determine the number of large new dimensions and the scale of quantum gravity.Comment: 5 pages, 3 figures, submitted to PRL. Results presented at the Les Houches Workshop "Physics at the TeV Colliders" (May 30, 2001) and the "Avatars of M-Theory" conference, ITP at Santa Barbara (June 7, 2001), http://online.itp.ucsb.edu/online/mtheory_c01/dimopoulo

Implementation costs of a multi-component program to increase human papillomavirus (HPV) vaccination in a network of pediatric clinics

Introduction: HPV vaccination is both a clinically and cost-effective way to prevent HPV-related cancers. Increased focus on preventing HPV infection and HPV-related cancers has motivated development of strategies to increase adolescent vaccination rates. This analysis estimates the average cost associated with implementing programs aimed at increasing HPV vaccination from the perspective of the clinic decision makers. As providers and healthcare organizations consider vaccination initiatives, it is important for them to understand the costs associated with implementing these programs. Methods: Healthcare provider assessment and feedback, reminders, and education; and parent education/reminder strategies were implemented in a large pediatric clinic network between October 2015 and February 2018 to improve HPV vaccination rates. A micro-costing method was used in 2018 to prospectively estimate program implementation costs with the clinic as the unit of analysis. A sensitivity analysis assessed the effects of variability in levels of participation. Results: Assessment and feedback reports and provider education were implemented among 51 clinics at average per clinic cost of $786 and$368 respectively. Electronic vaccination reminders were delivered to providers and parents at a per clinic cost of $824. The parent education implementation cost was$2,126 per clinic. Conclusion: The four complimentary HPV evidence-based strategies were delivered at a total cost of $157,534 or$4,749 per clinic, including staff training and participant recruitment, reaching 155,000 HPV vaccine eligible adolescents

Privatization and Prisons

Privatization means increased governmental reliance on the private sector, rather than on government agencies, to satisfy the needs of society. Since the word was first used in 1969,\u27 privatization has gained broad recognition and widespread acceptance, and,in recent years, a major trend toward privatization has developed in the United States and abroad. The reasons for this trend are both pragmatic and ideological. Pragmatists advocate privatization because it offers a more efficient way to provide goods and services. Ideological opponents of big government support privatization be-cause it reduces the role of government. Privatization is therefore an important movement in East and West, in developing and developed countries, in communist and capitalist nations. It has taken root even in China and the Soviet Union.Privatization in the United States has taken a different form than it has in other countries. Outside the United States, in both developing and developed countries, the principal form of privatization is denationalization-the divestment of state-owned enterprises (SOEs). In the United States, which has relatively few SOEs, state and local governments are implementing privatization primarily through contracting and, to a lesser degree, vouchers,franchises, free-market arrangements, and voluntary efforts. Contracting, however, is the primary method governments use to privatize prisons

Phenomenology, Astrophysics and Cosmology of Theories with Sub-Millimeter Dimensions and TeV Scale Quantum Gravity

We recently proposed a solution to the hierarchy problem not relying on low-energy supersymmetry or technicolor. Instead, the problem is nullified by bringing quantum gravity down to the TeV scale. This is accomplished by the presence of $n \geq 2$ new dimensions of sub-millimeter size, with the SM fields localised on a 3-brane in the higher dimensional space. In this paper we systematically study the experimental viability of this scenario. Constraints arise both from strong quantum gravitational effects at the TeV scale, and more importantly from the production of massless higher dimensional gravitons with TeV suppressed couplings. Theories with $n>2$ are safe due mainly to the infrared softness of higher dimensional gravity. For $n=2$, the six dimensional Planck scale must be pushed above $\sim 30$ TeV to avoid cooling SN1987A and distortions of the diffuse photon background. Nevertheless, the particular implementation of our framework within type I string theory can evade all constraints, for any $n \geq 2$, with string scale $m_s \sim 1$ TeV. We also explore novel phenomena resulting from the existence of new states propagating in the higher dimensional space. The Peccei-Quinn solution to the strong CP problem is revived with a weak scale axion in the bulk. Gauge fields in the bulk can mediate repulsive forces $\sim 10^6 - 10^8$ times stronger than gravity at sub-mm distances, and may help stabilize the proton. Higher-dimensional gravitons produced on our brane and captured on a different "fat" brane can provide a natural dark matter candidate.Comment: 51 pages, late

Probing Sub-Micron Forces by Interferometry of Bose-Einstein Condensed Atoms

We propose a technique, using interferometry of Bose-Einstein condensed alkali atoms, for the detection of sub-micron-range forces. It may extend present searches at 1 micron by 6 to 9 orders of magnitude, deep into the theoretically interesting regime of 1000 times gravity. We give several examples of both four-dimensional particles (moduli), as well as higher-dimensional particles -- vectors and scalars in a large bulk-- that could mediate forces accessible by this technique.Comment: 32 pages, 5 figures, RevTeX4, expanded discussion of interactions, references added, to appear in PR