Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease

Background: Phosphorylated tau (p-tau) epitopes in cerebrospinal fluid (CSF) are accurate biomarkers for a pathological and clinical diagnosis of Alzheimer's disease (AD) and are seen to be increased in preclinical stage of the disease. However, it is unknown if these increases transpire earlier, prior to amyloid-beta (Aβ) positivity as determined by position emission tomography (PET), and if an ordinal sequence of p-tau epitopes occurs at this incipient phase. Methods: We measured CSF concentrations of p-tau181, p-tau217 and p-tau231 in 171 participants across the AD continuum who had undergone Aβ ([18F]AZD4694) and tau ([18F]MK6240) position emission tomography (PET) and clinical assessment. Findings: All CSF p-tau biomarkers were accurate predictors of cognitive impairment but CSF p-tau217 demonstrated the largest fold-changes in AD patients in comparison to non-AD dementias and cognitively unimpaired individuals. CSF p-tau231 and p-tau217 predicted Aβ and tau to a similar degree but p-tau231 attained abnormal levels first. P-tau231 was sensitive to the earliest changes of Aβ in the medial orbitofrontal, precuneus and posterior cingulate before global Aβ PET positivity was reached. Interpretation: We demonstrate that CSF p-tau231 increases early in development of AD pathology and is a principal candidate for detecting incipient Aβ pathology for therapeutic trial application

Validation d’une procédure de dépistage du trouble de personnalité limite selon le Modèle alternatif pour les troubles de la personnalité du DSM-5

Objectifs La cinquième édition du Manuel diagnostique et statistique des troubles mentaux (DSM-5) inclut un Modèle alternatif pour les troubles de la personnalité (MATP), qui définit la pathologie de la personnalité en s’appuyant sur 2 principaux critères dimensionnels. Le critère A correspond à la sévérité du dysfonctionnement de la personnalité dans la sphère du soi et dans la sphère interpersonnelle, alors que le critère B propose 5 domaines pathologiques de la personnalité se déclinant en 25 facettes. Six troubles spécifiques, incluant le trouble de personnalité limite (TPL), sont définis dans le MATP sur la base des critères A et B. Il existe toutefois très peu de données à l’heure actuelle sur ces diagnostics tels qu’opérationnalisés dans le MATP. La présente étude vise à présenter des données québécoises sur cette récente opérationnalisation du TPL. Plus spécifiquement, nous présenterons d’abord une procédure, basée sur des questionnaires autorévélés couvrant les 2 critères principaux du MATP, permettant de générer le diagnostic. Puis, nous évaluerons sa validité : a) en documentant la prévalence du diagnostic dans un échantillon clinique ; b) en déterminant son degré de correspondance avec le diagnostic catégoriel « traditionnel » du TPL et avec une mesure dimensionnelle de symptomatologie associée au trouble ; c) en présentant des données de validité convergente avec des construits pertinents pour l’étude du TPL (impulsivité, agression) ; et d) en déterminant la validité incrémentielle de la procédure proposée par rapport à une approche simplifiée où seul le critère B serait considéré.Méthode Les données de 287 patients recrutés dans le cadre de la démarche d’admission au Centre de traitement le Faubourg Saint-Jean du CIUSSS-Capitale-Nationale ont été analysées. Le diagnostic de TPL selon le MATP a été généré à partir de 2 questionnaires validés, dans leur version francophone, soit le Self and Interpersonal Functioning Scale (critère A) et le Personality Inventory for DSM-5-Faceted Brief Form (critère B).Résultats Le diagnostic de TPL, tel qu’opérationnalisé par le MATP, présentait une prévalence de 39,7 % dans l’échantillon. Une correspondance modérée avec le diagnostic de TPL posé par les cliniciens selon le modèle catégoriel traditionnel du DSM-5 a été observée, de même qu’une forte corrélation avec une mesure dimensionnelle de symptomatologie limite. L’analyse du réseau nomologique a révélé des corrélations élevées et théoriquement attendues entre le trouble et des mesures d’agression et d’impulsivité. La procédure d’extraction du diagnostic, qui utilise les critères A et B, montre une validité incrémentielle dans la prédiction statistique des variables externes (symptomatologie limite, agression, impulsivité) par rapport à une procédure simplifiée n’utilisant que le critère B.Conclusions La procédure proposée pour générer le diagnostic de TPL selon la définition du MATP génère des résultats valides et pourrait permettre un dépistage du trouble selon cette conceptualisation contemporaine des pathologies de la personnalité.Objectives The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) includes an Alternative Model for Personality Disorders (DSM-5), which defines personality disorders based on two dimensional criteria. Criterion A corresponds to the severity of personality dysfunction in the areas of self and interpersonal functioning, while Criterion B comprises five pathological domains including a total of 25 facets. Six specific disorders, including borderline personality disorder (BPD), are defined in the AMPD based on Criteria A and B. However, there is currently very little data on these diagnoses as they are operationalized in the MATP. This study aims to present data on this recent operationalization of BPD. More specifically, we will first introduce a procedure, based on self-reported questionnaires covering the two main MATP criteria, implemented to generate the BPD diagnosis from the AMPD. Then, we will assess its validity (a) by documenting its prevalence in a clinical sample; (b) by determining its degree of correspondence with the “traditional” BPD categorical diagnosis and with a dimensional measure of borderline symptomatology; (c) by presenting convergent validity data with constructs relevant to the study of BPD (impulsivity, aggression); and (d) by determining the incremental validity of the proposed procedure in contrast with a simplified approach where only Criterion B would be considered.Method Data from 287 patients recruited as part of the admission process at the Centre de traitement le Faubourg Saint-Jean of the CIUSSS-Capitale-Nationale were analyzed. The BPD diagnosis from the MATP was generated based on two validated self-report questionnaires, in their French version, namely the Self and Interpersonal Functioning Scale (Criterion A) and the Personality Inventory for DSM-5-Faceted Brief Form (Criterion B).Results The BPD diagnosis, as operationalized in the AMPD, had a prevalence of 39.7% in the sample. A moderate fit with the clinician’s diagnosis of BPD according to the traditional DSM-5 categorical model was observed, as well as a strong correlation with a dimensional measure of borderline symptomatology. Nomological network analysis revealed high and theoretically expected correlations between the disorder and measures of aggression and impulsivity. The proposed diagnostic extraction procedure, which uses Criteria A and B, showed incremental validity in the statistical prediction of external variables (borderline symptomatology, aggression, impulsivity) compared to a simplified procedure using only Criterion B.Conclusions The proposed procedure for generating the BPD diagnosis according to the MATP definition yields promising results and could allow screening for the disorder based on this contemporary conceptualization of personality pathologies

The Experience of Couples in the Process of Treatment of Pathological Gambling: Couple vs. Individual Therapy

Context: Couple treatment for pathological gambling is an innovative strategy. There are some results supporting its potential effectiveness, but little is known about the subjective experiences of the participants.Objective: The aim of this article is to document the experiences of gamblers and their partners participating in one of two treatments, namely individual or couple.Method: In a study aiming to evaluate the efficacy of the Integrative Couple Treatment for Pathological Gambling (ICT-PG), couples who were entering specialized treatment for the addiction of one member who was a pathological gambler were randomly assigned to individual or ICT-PG. Nine months after their admission to treatment, gamblers and partners (n = 21 couples; n = 13 ICT-PG; n = 8 individual treatment) were interviewed in semi-structured interviews. A sequenced thematization method was used to extract the major themes.Results: This study highlighted five major themes in the therapeutic process noted by the gamblers and their partners mainly after the couple treatment but also partly through the individual therapy. These were: (1) the gamblers' anxiety about having to reveal their gambling problems in couple therapy; (2) the wish to develop a mutually beneficial understanding of gambling and its effects on the partners in the two types of treatments; (3) the transformation of negative attributions through a more effective intra-couple communication fostered by the couple therapy; (4) the partners' contribution to changes in gambling behavior and prevention of relapses, which were both better supported in couple therapy; and (5) the interpersonal nature of gambling and its connections with the couples' relationship. However, gamblers who were in individual treatment were more likely to mention that their partners' involvement was not necessary. Participants likewise made a few recommendations about the conditions underlying the choice of one treatment method or the other.Discussion: Participants reported satisfaction with both treatment models, but their experience was more positive in couple treatment. Complementary benefits emerged from each form of treatment, which points to future treatments involving both types. Future research should explore both the couple processes associated with attempts to stop pathological gambling and the various ways of involving partners in the gamblers' treatment

The association between nocturnal hot flashes and sleep in breast cancer survivors

This study examined the relationship between objectively measured nocturnal hot flashes and objectively measured sleep in breast cancer survivors with insomnia. Twenty-four women who had completed treatment for non-metastatic breast cancer participated. All were enrolled in a study of cognitive–behavioral treatment for chronic insomnia. Nocturnal hot flashes and sleep were measured by skin conductance and polysomnography, respectively. The 10-minute periods around hot flashes were found to have significantly more wake time, and more stage changes to lighter sleep, than other 10-minute periods during the night. Nights with hot flashes had a significantly higher percentage of wake time, a lower percentage of Stage 2 sleep, and a longer REM latency compared to nights without hot flashes. Overall, hot flashes were found to be associated with less efficient, more disrupted sleep. Nocturnal hot flashes, or their underlying mechanisms, should be considered as potential contributors to sleep disruption in women with breast cancer who report poor sleep

Integrative couple treatment for pathological gambling/ICT-PG : description of the therapeutic process

Problem gambling can have profound consequences on a person's life, consequences that range from financial, psychological to relational and that affect, in particular, couple relationships. Despite these widely documented relational consequences, most therapies for problem gambling favour an individual approach. Nonetheless, in the field of addiction, several studies have documented the efficacy of a couple approach. A few results from preliminary studies carried out with gamblers would seem to suggest that a couple approach might also be effective in this field. Our team thus developed the Integrative Couple Treatment for Pathological Gambling or ICT-PG, a therapy in which the treatment for pathological gambling starts by working with the couple from the very first meeting. First off, it targets the reduction or cessation of gambling behaviour, but also a reduction in the psychological distress of the two partners and an improvement in relationship satisfaction and mutual support. The usual work on diverse dimensions related to gambling is conducted with the gambler, and this in the presence and with the support of his partner. The treatment aims to eliminate those behaviours in the couple that might facilitate gambling and to reinforce behaviours that support the cessation of gambling. Another goal of the ICT-PG is for the couple to learn better skills for communication, conflict resolution, and mutual reinforcement, always with the objective of facilitating the reduction and cessation of gambling habits. This paper is a description of the therapeutic process of the ICT-PG.Le jeu compulsif peut avoir de profondes conséquences sur la vie d'une personne, des conséquences qui vont de l'ordre financier, psychologique à relationnel et qui affectent, en particulier les relations de couple. Malgré que ces conséquences sur les relations soient bien connues, la plupart des thérapies pour le jeu compulsif emploient une approche individuelle. Pourtant, dans le domaine de la dépendance, plusieurs études ont démontré l'efficacité d'une approche de couple. Quelques données préliminaires d’études avec des joueurs compulsifs suggèrent qu'une approche de couple pourrait aussi être efficace dans ce domaine. Notre équipe a donc développé le Traitement de couple intégratif pour le jeu pathologique ou TCI-JP, une thérapie dont le traitement pour le jeu pathologique débute avec le couple dès la première rencontre. Tout d'abord, la thérapie cible une réduction ou cessation du comportement de joueur de même qu'une réduction de la détresse psychologique chez les deux partenaires, une amélioration de la satisfaction de la relation et un support mutuel. Le travail habituel sur les diverses dimensions reliées au jeu compulsif est effectué avec le joueur en présence et avec le support du conjoint ou de la conjointe. Le traitement vise à éliminer les comportements du couple qui peuvent inciter à la pratique du jeu compulsif et à renforcir ceux qui mènent à une cessation. Un autre but du TCI-JP est de permettre aux couples de développer des compétences en communication, résolution de conflits et renforcement mutuel tout en maintenant l'objectif de faciliter la réduction et cessation des habitudes de jeu. Cet article décrit le procédé thérapeutique du TCI-JP

Facteurs pronostiques à la psychothérapie chez les troubles de la personnalité : implication de questionnaires autorapportés

Objectif Les taux d’abandon en psychothérapie sont reconnus comme étant élevés chez les patients/patientes souffrant de troubles de la personnalité (TP ; variant entre 25 % et 64 % pour le trouble de personnalité limite). Devant ce constat, la Grille de facteurs pronostiques à la psychothérapie (GFPP ; Gamache et coll., 2017) a été développée afin d’identifier précisément les patients/patientes souffrant de TP à haut risque d’abandonner la thérapie à partir de 15 critères, regroupés en 5 facteurs : Narcissisme pathologique, Antisocialité/Psychopathie, Gains secondaires, Faible motivation, Traits du groupe A. Par ailleurs, nous en connaissons relativement peu sur la pertinence des questionnaires autorapportés couramment utilisés auprès de la clientèle dans l’établissement du pronostic de traitement. Ainsi, le but de l’étude est d’évaluer les liens entre de tels questionnaires et les 5 facteurs de la GFPP.Méthode Un échantillon de 174 personnes avec un TP (dont 56 % avec traits ou TP limite), évaluées au Centre de traitement Le Faubourg Saint-Jean, ont rempli les versions françaises des questionnaires suivants : Borderline Symptom List (BSL-23), Brief Version of the Pathological Narcissism Inventory (B-PNI), Interpersonal Reactivity Index (IRI), Buss-Perry Aggression Questionnaire (BPAQ), Barratt Impulsiveness Scale (BIS-11), Questionnaire de fonctionnement social (QFS), Self and Interpersonal Functioning Scale (SIFS) et Personality Inventory for DSM-5- Faceted Brief Form (PID-5-FBF). La GFPP a été cotée par une équipe de psychologues expérimentés dans le traitement des TP. Des analyses descriptives et de régression entre les questionnaires autorapportés et les 5 facteurs de la GFPP de même que son score total ont été réalisées. Le but de ces analyses est de déterminer quelles variables des questionnaires autorapportés remplis par les personnes référées pour un TP, et principalement un TPL, contribuent le plus fortement à la prédiction statistique des variables de la GFPP cotée par les cliniciens.Résultats Les sous-échelles qui contribuent significativement au score du facteur Narcissisme pathologique (R2 ajusté = 0,12) sont : Empathie (SIFS), Impulsivité (inversement ; PID-5) et Rage revendicatrice (B-PNI). Les sous-échelles associées au facteur Antisocialité/Psychopathie (R2 ajusté = 0,24) sont Manipulation, Soumission (inversement) et Dureté du PID-5 ainsi que l’échelle Souci empathique de l’IRI. Les échelles contribuant substantiellement au facteur Gains secondaires (R2 ajusté = 0,20) sont Fréquence (QFS), Colère (inversement ; BPAQ), Fantaisie (inversement) et Souci empathique (IRI), Perfectionnisme rigide (inversement) et Croyances inhabituelles (PID-5). Le facteur Faible motivation (R2 ajusté = 0,10) est expliqué significativement par le score total au BSL (inversement) et la sous-échelle Satisfaction (QFS). Finalement, les sous-échelles significativement associées au facteur Traits du groupe A (R2 ajusté = 0,09) sont Intimité (SIFS) et Soumission (inversement ; PID-5).Conclusion : Certaines échelles des instruments autorapportés montrent des associations modestes, mais significatives avec les résultats obtenus aux facteurs de la GFPP. Ces échelles pourraient donc s’avérer utiles dans la cotation de la GFPP et fournir des informations complémentaires pour l’orientation clinique.Objectives Dropout rates in psychotherapy are known to be high in patients with personality disorders (PD; ranging from 25% and 64% for Borderline PD). Faced with this observation, the Treatment Attrition-Retention Scale for Personality Disorders (TARS-PD; Gamache et coll., 2017) was developed to precisely identify patients with PD at high risk of abandoning therapy based on 15 criteria, regrouped in 5 factors: Pathological Narcissism, Antisocial/Psychopathy, Secondary Gain, Low Motivation, and Cluster A Features. However, we have limited knowledge about the relevance of self-reported questionnaires commonly used with PD patients to establish treatment prognosis. Thus, the purpose of this study is to evaluate the link between such questionnaires and the five factors of the TARS-PD.Method Data was retrospectively retrieved from the clinical files of 174 participants with a PD (including 56% with borderline traits or PD), who were evaluated at the Centre de traitement le Faubourg Saint-Jean and completed the French version of the following questionnaires: Borderline Symptom List (BSL-23), Brief Version of the Pathological Narcissism Inventory (B-PNI), Interpersonal Reactivity Index (IRI), Buss-Perry Aggression Questionnaire (BPAQ), Barratt Impulsiveness Scale (BIS-11), Social Functioning Questionnaire (SFQ), Self and Interpersonal Functioning Scale (SIFS) and Personality Inventory for DSM-5- Faceted Brief Form (PID-5-FBF). The TARS-PD was completed by well-trained psychologists specialized in PD treatment. Descriptive analyses and regression between self-reported questionnaires and the five factors of the TARS-PD as well as its total score were performed to determine which variables from the self-reported questionnaires completed by the individuals contribute most strongly to the statistical prediction of the variables of the TARS-PD rated by the clinicians.Results The subscales that significantly contribute to the Pathological Narcissism factor (adjusted R2=0,12) are: Empathy (SIFS), Impulsivity (negatively; PID-5), and Entitlement Rage (B-PNI). The subscales associated with the Antisociality/Psychopathy factor (adjusted R2=0,24) are Manipulativeness, Submissiveness (negatively), and Callousness from the PID-5, and Empathic Concern (IRI). The scales contributing substantially to the Secondary gains factor (adjusted R2=0,20) are Frequency (SFQ), Anger (negatively; BPAQ), Fantasy (negatively) and Empathic Concern (IRI), Rigid Perfectionism (negatively) and Unusual Beliefs and Experiences (PID-5). Low motivation (adjusted R2=0,10) is significantly explained by Total BSL score (negatively) and Satisfaction (SFQ) subscale. Finally, the subscales significantly associated to Cluster A features (adjusted R2=0,09) are Intimacy (SIFS) and Submissiveness (negatively, PID-5).Conclusion Some scales from self-reported questionnaires demonstrated modest but significant associations with TARS-PD factors. Those scales might be useful in the scoring of the TARS-PD and provide additional information for patients’ clinical orientation

Violence conjugale commise et subie : profils personnologiques de personnes avec un trouble de personnalité limite

Objectif Les troubles de la personnalité et la violence conjugale (VC) sont deux problématiques reconnues comme des enjeux majeurs en santé publique associées à de graves répercussions individuelles et sociétales. Plusieurs études ont documenté les liens entre le trouble de personnalité limite (TPL) et la VC, mais nous en connaissons très peu quant aux traits pathologiques spécifiques contribuant à la VC. L’étude vise à documenter le phénomène de VC commise et subie chez des personnes souffrant de TPL et à dresser des profils à partir des facettes de la personnalité du Modèle alternatif pour les troubles de la personnalité du DSM-5.Méthode Cent huit participants/participantes avec un TPL (83,3 % femmes ; Mâge = 32,39, É.-T. = 9) référées à un programme d’hôpital de jour à la suite d’un épisode de crise ont rempli une batterie de questionnaires comprenant les versions françaises du Revised Conflict Tactics Scales, évaluant la VC psychologique et physique, commise et subie, et du Personality Inventory for the DSM-5 — FacetedBrief Form, évaluant 25 facettes pathologiques de la personnalité.Résultats Parmi les participants/participantes, 78,7 % rapportent avoir déjà commis de la VC psychologique, alors que 68,5 % en auraient été victimes, ce qui est plus que les estimations publiées par l’Organisation mondiale de la santé (27 %). De plus, 31,5 % auraient commis de la VC physique, alors que 22,2 % en auraient été victimes. La VC semble bidirectionnelle puisque 85,9 % des personnes ayant commis de la VC psychologique rapportent aussi en subir et 52,9 % des personnes ayant commis de la VC physique rapportent en être également victimes. Des comparaisons de groupes non paramétriques indiquent que les facettes Hostilité, Méfiance, Duplicité, Prise de risques et Irresponsabilité distinguent les personnes violentes physiquement et psychologiquement des personnes non violentes. Des résultats élevés aux facettes Hostilité, Dureté/Insensibilité, Manipulation et Prise de risque caractérisent les participants/participantes victimes de VC psychologique, alors qu’une élévation aux facettes Hostilité, Retrait, Évitement de l’intimité et Prise de risque et un résultat faible à la facette Tendance à la soumission distinguent les participants/participantes victimes de VC physique des non-victimes. Des analyses de régression mettent en évidence que la facette Hostilité explique à elle seule une variance significative des résultats de VC commise, alors que la facette Irresponsabilité contribuerait de façon substantielle à la variance des résultats de VC subie.Conclusion Les résultats font état de la prévalence élevée de VC chez des personnes aux prises avec un TPL ainsi que de son caractère bidirectionnel. Au-delà du diagnostic de TPL, certaines facettes spécifiques de la personnalité (dont l’Hostilité et l’Irresponsabilité) permettent de cibler les personnes plus à risque de commettre de la VC psychologique et physique et d’en subir.Objective Personality disorders and intimate partner violence (IPV) are two problems recognized as major public health issues associated with serious individual and societal repercussions. Several studies have documented the links between borderline personality disorder (BPD) and IPV; however, we know very little about the specific pathological traits contributing to IPV. The study aims to document the phenomenon of IPV committed and suffered in persons with BPD and to draw profiles from the personality facets of the DSM-5 Alternative Model for Personality Disorders (AMPD).Method One hundred and eight BPD participants (83.3% female; Mage = 32.39, SD = 9.00) referred to a day hospital program following a crisis episode completed a battery of questionnaires including the French versions of the Revised Conflict Tactics Scales, evaluating physical and psychological IPV committed and suffered, and the Personality Inventory for the DSM-5- Faceted Brief Form, evaluating 25 pathological facets of personality.Results Among the participants, 78.7% report having committed psychological IPV, while 68.5% have been victims, which is more than the estimates published by the World Health Organization (27%). In addition, 31.5% would have committed physical IPV, while 22.2% would have been victims. IPV appears to be bidirectional since 85.9% of participants who are perpetrators of psychological IPV also report suffering from it and 52.9% of participants who are perpetrators of physical IPV report being also victims. Nonparametric group comparisons indicate that Hostility, Suspiciousness, Duplicity, Risk-Taking, and Irresponsibility facets distinguish physically and psychologically violent participants from nonviolent participants. High results on Hostility, Callousness, Manipulation, and Risk-taking facets characterize participants who are victims of psychological IPV, while an elevation in Hostility, Withdrawal, Avoidance of intimacy, and Risk-taking facets and a low result on the Submission facet distinguish participants who are victims of physical IPV from non-victims. Regression analyzes show that the Hostility facet alone explains a significant variance in the results of IPV perpetrated, while the Irresponsibility facet contributes substantially to the variance of the results of IPV experienced.Conclusion Results show the high prevalence of IPV in a sample of persons with BPD, as well as its bidirectional nature. Beyond the diagnosis of BPD, certain specific facets of the personality (including Hostility and Irresponsability) make it possible to target persons at greater risk of committing and suffering from psychological and physical IPV

Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer's Disease

Background: Both subjective cognitive decline (SCD) and a family history of Alzheimer's disease (AD) portend risk of brain abnormalities and progression to dementia. Posterior default mode network (pDMN) connectivity is altered early in the course of AD. It is unclear whether SCD predicts similar outcomes in cognitively normal individuals with a family history of AD. Methods: We studied 124 asymptomatic individuals with a family history of AD (age 64 ± 5 years). Participants were categorized as having SCD if they reported that their memory was becoming worse (SCD+). We used extensive neuropsychological assessment to investigate five different cognitive domain performances at baseline (n = 124) and 1 year later (n = 59). We assessed interconnectivity among three a priori defined ROIs: pDMN, anterior ventral DMN, medial temporal memory system (MTMS), and the connectivity of each with the rest of brain. Results: Sixty-eight (55%) participants reported SCD. Baseline cognitive performance was comparable between groups (all false discovery rate-adjusted p values >.05). At follow-up, immediate and delayed memory improved across groups, but the improvement in immediate memory was reduced in SCD+ compared with SCD− (all false discovery rate–adjusted p values <.05). When compared with SCD−, SCD+ subjects showed increased pDMN–MTMS connectivity (false discovery rate–adjusted p <.05). Higher connectivity between the MTMS and the rest of the brain was associated with better baseline immediate memory, attention, and global cognition, whereas higher MTMS and pDMN–MTMS connectivity were associated with lower immediate memory over time (all false discovery rate–adjusted p values <.05). Conclusions: SCD in cognitively normal individuals is associated with diminished immediate memory practice effects and a brain connectivity pattern that mirrors early AD-related connectivity failure

Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer’s disease

We present a test-retest dataset of resting-state fMRI data obtained in 80 cognitively normal elderly volunteers enrolled in the “Pre-symptomatic Evaluation of Novel or Experimental Treatments for Alzheimer's Disease” (PREVENT-AD) Cohort. Subjects with a family history of Alzheimer's disease in first-degree relatives were recruited as part of an on-going double blind randomized clinical trial of Naproxen or placebo. Two pairs of scans were acquired ~3 months apart, allowing the assessment of both intra- and inter-session reliability, with the possible caveat of treatment effects as a source of inter-session variation. Using the NeuroImaging Analysis Kit (NIAK), we report on the standard quality of co-registration and motion parameters of the data, and assess their validity based on the spatial distribution of seed-based connectivity maps as well as intra- and inter-session reliability metrics in the default-mode network. This resource, released publicly as sample UM1 of the Consortium for Reliability and Reproducibility (CoRR), will benefit future studies focusing on the preclinical period preceding the appearance of dementia in Alzheimer's disease