516 research outputs found
Prospects For Identifying Dark Matter With CoGeNT
It has previously been shown that the excess of events reported by the CoGeNT
collaboration could be generated by elastically scattering dark matter
particles with a mass of approximately 5-15 GeV. This mass range is very
similar to that required to generate the annual modulation observed by
DAMA/LIBRA and the gamma rays from the region surrounding the Galactic Center
identified within the data of the Fermi Gamma Ray Space Telescope. To
confidently conclude that CoGeNT's excess is the result of dark matter,
however, further data will likely be needed. In this paper, we make projections
for the first full year of CoGeNT data, and for its planned upgrade. Not only
will this body of data more accurately constrain the spectrum of nuclear recoil
events, and corresponding dark matter parameter space, but will also make it
possible to identify seasonal variations in the rate. In particular, if the
CoGeNT excess is the product of dark matter, then one year of CoGeNT data will
likely reveal an annual modulation with a significance of 2-3. The
planned CoGeNT upgrade will not only detect such an annual modulation with high
significance, but will be capable of measuring the energy spectrum of the
modulation amplitude. These measurements will be essential to irrefutably
confirming a dark matter origin of these events.Comment: 6 pages, 6 figure
Dependence of direct detection signals on the WIMP velocity distribution
The signals expected in WIMP direct detection experiments depend on the
ultra-local dark matter distribution. Observations probe the local density,
circular speed and escape speed, while simulations find velocity distributions
that deviate significantly from the standard Maxwellian distribution. We
calculate the energy, time and direction dependence of the event rate for a
range of velocity distributions motivated by recent observations and
simulations, and also investigate the uncertainty in the determination of WIMP
parameters. The dominant uncertainties are the systematic error in the local
circular speed and whether or not the MW has a high density dark disc. In both
cases there are substantial changes in the mean differential event rate and the
annual modulation signal, and hence exclusion limits and determinations of the
WIMP mass. The uncertainty in the shape of the halo velocity distribution is
less important, however it leads to a 5% systematic error in the WIMP mass. The
detailed direction dependence of the event rate is sensitive to the velocity
distribution. However the numbers of events required to detect anisotropy and
confirm the median recoil direction do not change substantially.Comment: 21 pages, 7 figures, v2 version to appear in JCAP, minor change
Cerebrovascular endothelial cells form transient Notchâdependent cystic structures in zebrafish
We identify a novel endothelial membrane behaviour in transgenic zebrafish. Cerebral blood vessels extrude large transient spherical structures that persist for an average of 23 min before regressing into the parent vessel. We term these structures âkugelnâ, after the German for sphere. Kugeln are only observed arising from the cerebral vessels and are present as late as 28 days post fertilization. Kugeln do not communicate with the vessel lumen and can form in the absence of blood flow. They contain little or no cytoplasm, but the majority are highly positive for nitric oxide reactivity. Kugeln do not interact with brain lymphatic endothelial cells (BLECs) and can form in their absence, nor do they perform a scavenging role or interact with macrophages. Inhibition of actin polymerization, Myosin II, or Notch signalling reduces kugel formation, while inhibition of VEGF or Wnt dysregulation (either inhibition or activation) increases kugel formation. Kugeln represent a novel Notchâdependent NOâcontaining endothelial organelle restricted to the cerebral vessels, of currently unknown function
Ice sheet model dependency of the simulated Greenland Ice Sheet in the mid-Pliocene
The understanding of the nature and behavior of ice sheets in past warm periods is important for constraining the potential impacts of future climate change. The Pliocene warm period (between 3.264 and 3.025 Ma) saw global temperatures similar to those projected for future climates; nevertheless, Pliocene ice locations and extents are still poorly constrained. We present results from the efforts to simulate mid-Pliocene Greenland Ice Sheets by means of the international Pliocene Ice Sheet Modeling Intercomparison Project (PLISMIP). We compare the performance of existing numerical ice sheet models in simulating modern control and mid-Pliocene ice sheets with a suite of sensitivity experiments guided by available proxy records. We quantify equilibrated ice sheet volume on Greenland, identifying a potential range in sea level contributions from warm Pliocene scenarios. A series of statistical measures are performed to quantify the confidence of simulations with focus on inter-model and inter-scenario differences. We find that Pliocene Greenland Ice Sheets are less sensitive to differences in ice sheet model configurations and internal physical quantities than to changes in imposed climate forcing. We conclude that Pliocene ice was most likely to be limited to the highest elevations in eastern and southern Greenland as simulated with the highest confidence and by synthesizing available regional proxies; however, the extent of those ice caps needs to be further constrained by using a range of general circulation model (GCM) climate forcings
Theoretical predictions for the direct detection of neutralino dark matter in the NMSSM
We analyse the direct detection of neutralino dark matter in the framework of
the Next-to-Minimal Supersymmetric Standard Model. After performing a detailed
analysis of the parameter space, taking into account all the available
constraints from LEPII, we compute the neutralino-nucleon cross section, and
compare the results with the sensitivity of detectors. We find that sizable
values for the detection cross section, within the reach of dark matter
detectors, are attainable in this framework. For example, neutralino-proton
cross sections compatible with the sensitivity of present experiments can be
obtained due to the exchange of very light Higgses with m_{h_1^0}\lsim 70
GeV. Such Higgses have a significant singlet composition, thus escaping
detection and being in agreement with accelerator data. The lightest neutralino
in these cases exhibits a large singlino-Higgsino composition, and a mass in
the range 50\lsim m_{\tilde\chi_1^0}\lsim 100 GeV.Comment: Final version to appear in JHEP. References added. LaTeX, 53 pages,
23 figure
Results of Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial
BACKGROUND: Restenosis after percutaneous coronary intervention (PCI) is a major problem affecting 15% to 30% of patients after stent placement. No oral agent has shown a beneficial effect on restenosis or on associated major adverse cardiovascular events. In limited trials, the oral agent tranilast has been shown to decrease the frequency of angiographic restenosis after PCI. METHODS AND RESULTS: In this double-blind, randomized, placebo-controlled trial of tranilast (300 and 450 mg BID for 1 or 3 months), 11 484 patients were enrolled. Enrollment and drug were initiated within 4 hours after successful PCI of at least 1 vessel. The primary end point was the first occurrence of death, myocardial infarction, or ischemia-driven target vessel revascularization within 9 months and was 15.8% in the placebo group and 15.5% to 16.1% in the tranilast groups (P=0.77 to 0.81). Myocardial infarction was the only component of major adverse cardiovascular events to show some evidence of a reduction with tranilast (450 mg BID for 3 months): 1.1% versus 1.8% with placebo (P=0.061 for intent-to-treat population). The primary reason for not completing treatment was > or =1 hepatic laboratory test abnormality (11.4% versus 0.2% with placebo, P<0.01). In the angiographic substudy composed of 2018 patients, minimal lumen diameter (MLD) was measured by quantitative coronary angiography. At follow-up, MLD was 1.76+/-0.77 mm in the placebo group, which was not different from MLD in the tranilast groups (1.72 to 1.78+/-0.76 to 80 mm, P=0.49 to 0.89). In a subset of these patients (n=1107), intravascular ultrasound was performed at follow-up. Plaque volume was not different between the placebo and tranilast groups (39.3 versus 37.5 to 46.1 mm(3), respectively; P=0.16 to 0.72). CONCLUSIONS: Tranilast does not improve the quantitative measures of restenosis (angiographic and intravascular ultrasound) or its clinical sequelae
Quantum Experimental Data in Psychology and Economics
We prove a theorem which shows that a collection of experimental data of
probabilistic weights related to decisions with respect to situations and their
disjunction cannot be modeled within a classical probabilistic weight structure
in case the experimental data contain the effect referred to as the
'disjunction effect' in psychology. We identify different experimental
situations in psychology, more specifically in concept theory and in decision
theory, and in economics (namely situations where Savage's Sure-Thing Principle
is violated) where the disjunction effect appears and we point out the common
nature of the effect. We analyze how our theorem constitutes a no-go theorem
for classical probabilistic weight structures for common experimental data when
the disjunction effect is affecting the values of these data. We put forward a
simple geometric criterion that reveals the non classicality of the considered
probabilistic weights and we illustrate our geometrical criterion by means of
experimentally measured membership weights of items with respect to pairs of
concepts and their disjunctions. The violation of the classical probabilistic
weight structure is very analogous to the violation of the well-known Bell
inequalities studied in quantum mechanics. The no-go theorem we prove in the
present article with respect to the collection of experimental data we consider
has a status analogous to the well known no-go theorems for hidden variable
theories in quantum mechanics with respect to experimental data obtained in
quantum laboratories. For this reason our analysis puts forward a strong
argument in favor of the validity of using a quantum formalism for modeling the
considered psychological experimental data as considered in this paper.Comment: 15 pages, 4 figure
Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development
Aims
Vertebrate heart development requires the complex morphogenesis of a linear tube to form the mature organ, a process essential for correct cardiac form and function, requiring coordination of embryonic laterality, cardiac growth, and regionalized cellular changes. While previous studies have demonstrated broad requirements for extracellular matrix (ECM) components in cardiac morphogenesis, we hypothesized that ECM regionalization may fine tune cardiac shape during heart development.
Methods and results
Using live in vivo light sheet imaging of zebrafish embryos, we describe a left-sided expansion of the ECM between the myocardium and endocardium prior to the onset of heart looping and chamber ballooning. Analysis using an ECM sensor revealed the cardiac ECM is further regionalized along the atrioventricular axis. Spatial transcriptomic analysis of gene expression in the heart tube identified candidate genes that may drive ECM expansion. This approach identified regionalized expression of hapln1a, encoding an ECM cross-linking protein. Validation of transcriptomic data by in situ hybridization confirmed regionalized hapln1a expression in the heart, with highest levels of expression in the future atrium and on the left side of the tube, overlapping with the observed ECM expansion. Analysis of CRISPR-Cas9-generated hapln1a mutants revealed a reduction in atrial size and reduced chamber ballooning. Loss-of-function analysis demonstrated that ECM expansion is dependent upon Hapln1a, together supporting a role for Hapln1a in regionalized ECM modulation and cardiac morphogenesis. Analysis of hapln1a expression in zebrafish mutants with randomized or absent embryonic leftâright asymmetry revealed that laterality cues position hapln1a-expressing cells asymmetrically in the left side of the heart tube.
Conclusion
We identify a regionalized ECM expansion in the heart tube which promotes correct heart development, and propose a novel model whereby embryonic laterality cues orient the axis of ECM asymmetry in the heart, suggesting these two pathways interact to promote robust cardiac morphogenesis
A Conflict Model for Strategists and Managers
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67210/2/10.1177_000276427201500604.pd
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