Ground state of trapped interacting Bose-Einstein condensates by an explicit imaginary-time algorithm

We show that an explicit time-marching method previously developed for the numerical study of the dynamics of Bose-Einstein condensates can be profitably adapted to the numerical determination of their ground state. After reduction to a one-dimensional model, we first reproduce and test known results on condensates in harmonic traps and then determine the ground state of a condensate in a harmonically bound optical lattice in the range of parameters which are relevant to existing experiments

SUSApp: a mobile app for measuring and comparing questionnaire-based usability assessments

Usability questionnaires are one of the most used methods to measure usability in terms of the user’s subjective satisfaction. However, most of the usability questionnaires do not provide a complete environment to store measurements and compare different usability values of application categories and versions over the long term, which makes it difficult to study the usability of a software product or even the usability of different versions of such products over time, hindering the facility to obtain comparisons and thresholds in usability measurements for different product lines. In this paper we present SUSApp, a tool conceived for the analysis of usability through the SUS (System Usability Scale) questionnaire, which is one of the most popular ones. This tool was conceived for mobile platforms, and it is intended to easily analyze usability by storing and recovering past evaluations, and allowing to statistically compare usability measurements among different software products and applications categories. In addition, a user testing is presented. This has provided acceptable usability results concerning SUSApp in an experiment with real usersThis work has been partially supported by the funding projects «eMadrid-CM», granted by the Madrid Research Council (project code S2013/ICE-2715), and «Flexor» granted by the Spanish Government (project code TIN2014-52129-R

Numerical solution of the Gross-Pitaevskii equation using an explicit finite-difference scheme: An application to trapped Bose-Einstein condensates

A fast, explicit time-marching scheme is used for the solution of the Gross-Pitaevskii equation in cylindrical geometry. Scheme validity is analyzed using simple analytical tests and is demonstrated for two situations of physical interest on the Bose-Einstein condensation (BEC) of trapped alkali-metal vapors. This is tested using reproduced results on the free expansion of a BEC after removing a cylindrical trap

Transcriptome analysis of differentiating spermatogonia stimulated with kit ligand

Kit ligand (KL) is a survival factor and a mitogenic stimulus for differentiating spermatogonia. However, it is not known whether KL also plays a role in the differentiative events that lead to meiotic entry of these cells. We performed a wide genome analysis of difference in gene expression induced by treatment with KL of spermatogonia from 7-day-old mice, using gene chips spanning the whole mouse genome. The analysis revealed that the pattern of RNA expression induced by KL is compatible with the qualitative changes of the cell cycle that occur during the subsequent cell divisions in type A and B spermatogonia, i.e. the progressive lengthening of the S phase and the shortening of the G2/M transition. Moreover, KL up-regulates in differentiating spermatogonia the expression of early meiotic genes (for instance: Lhx8, Nek1, Rnf141, Xrcc3, Tpo1, Tbca, Xrcc2, Mesp1, Phf7, Rtel1), whereas it down-regulates typical spermatogonial markers (for instance: Pole, Ptgs2, Zfpm2, Egr2, Egr3, Gsk3b, Hnrpa1, Fst, Ptch2). Since KL modifies the expression of several genes known to be up-regulated or down-regulated in spermatogonia during the transition from the mitotic to the meiotic cell cycle, these results are consistent with a role of the KL/kit interaction in the induction of their meiotic differentiation

Do (and say) as I say: Linguistic adaptation in human-computer dialogs

© Theodora Koulouri, Stanislao Lauria, and Robert D. Macredie. This article has been made available through the Brunel Open Access Publishing Fund.There is strong research evidence showing that people naturally align to each other’s vocabulary, sentence structure, and acoustic features in dialog, yet little is known about how the alignment mechanism operates in the interaction between users and computer systems let alone how it may be exploited to improve the efficiency of the interaction. This article provides an account of lexical alignment in human–computer dialogs, based on empirical data collected in a simulated human–computer interaction scenario. The results indicate that alignment is present, resulting in the gradual reduction and stabilization of the vocabulary-in-use, and that it is also reciprocal. Further, the results suggest that when system and user errors occur, the development of alignment is temporarily disrupted and users tend to introduce novel words to the dialog. The results also indicate that alignment in human–computer interaction may have a strong strategic component and is used as a resource to compensate for less optimal (visually impoverished) interaction conditions. Moreover, lower alignment is associated with less successful interaction, as measured by user perceptions. The article distills the results of the study into design recommendations for human–computer dialog systems and uses them to outline a model of dialog management that supports and exploits alignment through mechanisms for in-use adaptation of the system’s grammar and lexicon

Differential contribution of the MTOR and MNK pathways to the regulation of mRNA translation in meiotic and postmeiotic mouse male germ cells

Translation of stored mRNAs accounts for protein synthesis during the transcriptionally inactive stages of spermatogenesis. A key step in mRNA translation is the assembly of the initiation complex EIF4F, which is regulated by the MTOR (mammalian target of rapamycin) and MNK1/2 (MAP kinase-interacting kinase 1 and 2) pathways. We investigated the expression and activity of regulatory proteins of these pathways in male germ cells at different stages of differentiation. All translation factors analyzed were expressed in germ cells throughout spermatogenesis. However, while EIF4G and PABP1 (poly[A]-binding protein 1) were more abundant in postmeiotic cells, MTOR and its target EIF4EBP1 (4E-BP1) decreased steadily during spermatogenesis. In vivo labeling showed that pachytene spermatocytes display higher rates of protein synthesis, which are partially dependent on MTOR and MNK activity. By contrast, haploid spermatids are characterized by lower levels of protein synthesis, which are independent of the activity of these pathways. Accordingly, MTOR and MNK activity enhanced formation of the EIF4F complex in pachytene spermatocytes but not in round spermatids. Moreover, external cues differentially modulated the activity of these pathways in meiotic and haploid cells. Heat shock decreased MTOR and MNK activity in pachytene spermatocytes, whereas round spermatids were much less sensitive. On the other hand, treatment with the phosphatase inhibitor okadaic acid activated MTOR and MNK in both cell types. These results indicate that translational regulation is differentially dependent on the MTOR and MNK pathways in mouse spermatocytes and spermatids and suggest that the late stages of germ cell differentiation display constitutive assembly of the translation initiation complex