191 research outputs found
Estimation of Normalized Eigenmodes and Natural Frequencies by Using the Effect of Accelerometers Mass
Several studies have been attempted to grasp the modal characteristics in machine operation. Derivation of the scaling factor for normalized eigenmodes is one of the important issues in operational modal analysis. In this study, we propose a procedure with the mass of piezoelectric acceleration transducers. Then the vibration testing for the mass change method is performed without using additional masses. We obtain the modal characteristics from the acquired acceleration responses by the transducers that is less than all measurement points. That is, the measurement is performed multiple times by changing the measurement locations. A modified procedure is proposed to calculate the scaling factor for normalized eigenmodes and proper natural frequencies by removing the influence of the mass of the added piezoelectric accelerometer. The validity of the proposed method is verified by numerical calculations and experiments of a rectangular plate
<Abstract of Published Report>Pulmonary Delivery of Insulin with Nebulized DL-Lactide/Glycolide Copolymer(PLGA) Nanospheres to Prolong Hypoglycemic Effect.
Study on the reusability of fluorescent nuclear track detectors using optical bleaching
Fluorescent nuclear track detectors (FNTDs) based on AlO:C,Mg
crystals are luminescent detectors that can be used for dosimetry and detection
of charged particles and neutrons. These detectors can be utilised for imaging
applications where a reasonably high track density, approximately of the order
of 1 tracks in an area of 100 100 m, is
required. To investigate the reusability of FNTDs for imaging applications, we
present an approach to perform optical bleaching under the required track
density conditions. The reusability was assessed through seven
irradiation-bleaching cycles. For the irradiation, the studied FNTD was exposed
to alpha-particles from an Am radioactive source. The optical bleaching
was performed by means of ultraviolet laser light with a wavelength of 355 nm.
Three dedicated regions on a single FNTD with different accumulated track
densities and bleaching conditions were investigated. After every
irradiation-bleaching cycle, signal-to-noise ratio was calculated to evaluate
FNTD performance. It is concluded that FNTDs can be reused at least seven times
for applications where accumulation of a high track density is required
<Abstract of published report>Formulation of w/o/w lipiodol emulsion encapsulating epirubicin hydrochloride for the transcatheter arterial embolization therapy for hepatocellular carcinoma.
<Abstract of Published Report>Formulation and in vivo evaluation of w/o/w emulsion encapsulating Epirubicin hydrochloride for the transcatheter arterial embolization therapy for hepatocellular carcinoma.
<Abstract of Published Report>Evaluation of Acute Toxicity of Epirubicin Hydrochloride-encapsulating w/o/w Emulsion Administered to Rat for the Transcatheter Embolization Therapy for Hepatocellular Carcinoma.
<Abstract of Published Report>Comparison of Lipiodol Water-in-Oil-in-Water Emulsion and Oil-in-Water Emulsion : Acute Toxicity and Deposition in Liver after Hepatic Arterial Administration in Rats.
A new cancer diagnostic system based on a CDK profiling technology
AbstractA series of molecular pathological investigations of the molecules that stimulate the cyclin dependent kinases (CDK1, 2, 4, and 6) have led to enormous accumulation of knowledge of the clinical significance of these molecules for cancer diagnosis. However, the molecules have yet to be applied to clinical cancer diagnosis, as there is no available technology for application of the knowledge in a clinical setting. We hypothesized that the direct measurement of CDK activities and expressions (CDK profiling) might produce clinically relevant values for the diagnosis. This study investigated the clinical relevance of CDK profiling in gastrointestinal carcinoma tissues by using originally developed expression and activity analysis methods. We have established novel methods and an apparatus for analyzing the expression and activities of the CDK molecules in lysate of tumor tissue in a clinical setting, and examined 30 surgically dissected gastrointestinal carcinomas and corresponding normal mucosal specimens. We demonstrate here that remarkably elevated CDK2 activity is evident in more than 70% of carcinoma tissues. Moreover, a G1-CDK activity profiling accurately mirrored the differences in proliferation between tumor and normal colonic tissues. Our results suggest that CDK profiling is a potent molecular–clinical approach to complement the conventional pathological diagnosis, and to further assist in the individualized medications
The effects of perioperative oral management on perioperative serum albumin levels in patients treated surgically under general anesthesia : A multicenter retrospective analysis in Japan
The purpose of the present study was to investigate the efficacy of perioperative oral managements (POMs) on perioperative nutritional conditions in patients undergoing surgery with general anesthesia. Medical records were retrospectively reviewed and the effects of POMs were investigated based on a large number of cases using a multicenter analysis. The profile of serum albumin levels was assessed and compared between patients with and without POMs using the multivariate analysis. Seventeen Eleven thousand and one hundred sixty patients (4,873 males and 6,287 females) were reviewed. Of these, 2710 patients (24.3%) had undergone POMs. The results of a multivariate analysis revealed the significant positive effect of POMs on perioperative serum albumin level (change between at admission and discharge, (Estimate: 0.022, standard error: 0.012, P < .0001). Patient gender, age, surgical site, performance status, the American Society of Anesthesiologists (ASA) physical status classification, operation time, amount of blood loss, and serum albumin level at admission were also significant predictors. Adjusted multivariate analysis of the effects of POMs on perioperative change of serum albumin level in all subjects reveled the significance of POMs intervention (estimate: 0.022, standard error: 0.012, P < .0001). These results suggest that POMs exerts significant positive effects on perioperative serum albumin levels in patients underwent surgery under general anesthesia
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